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Carbon nanohorns allow acceleration of osteoblast differentiation via macrophage activation


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タイトル: Carbon nanohorns allow acceleration of osteoblast differentiation via macrophage activation
著者: Hirata, Eri 著作を一覧する
Miyako, Eijiro 著作を一覧する
Hanagata, Nobutaka 著作を一覧する
Ushijima, Natsumi 著作を一覧する
Sakaguchi, Norihito 著作を一覧する
Russier, Julie 著作を一覧する
Yudasaka, Masako 著作を一覧する
Iijima, Sumio 著作を一覧する
Bianco, Alberto 著作を一覧する
Yokoyama, Atsuro 著作を一覧する
発行日: 2016年 8月
出版者: Royal Society of Chemistry
誌名: Nanoscale
巻: 8
号: 30
開始ページ: 14514
終了ページ: 14522
出版社 DOI: 10.1039/c6nr02756c
抄録: Carbon nanohorns (CNHs), formed by a rolled graphene structure and terminating in a cone, are promising nanomaterials for the development of a variety of biological applications. Here we demonstrate that alkaline phosphatase activity is dramatically increased by coculture of human monocyte derived macrophages (hMDMs) and human mesenchymal stem cells (hMSCs) in the presence of CNHs. CNHs were mainly localized in the lysosome of macrophages more than in hMSCs during coculturing. At the same time, the amount of Oncostatin M (OSM) in the supernatant was also increased during incubation with CNHs. Oncostatin M (OSM) from activated macrophage has been reported to induce osteoblast differentiation and matrix mineralization through STAT3. These results suggest that the macrophages engulfed CNHs and accelerated the differentiation of mesenchymal stem cells into the osteoblast via OSM release. We expect that the proof-of-concept on the osteoblast differentiation capacity by CNHs will allow future studies focused on CNHs as ideal therapeutic materials for bone regeneration.
資料タイプ: article
出現コレクション:雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

提供者: 平田 恵理


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