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Hokkaido University Collection of Scholarly and Academic Papers >
Graduate School of Dental Medicine / Faculty of Dental Medicine >
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Carbon nanohorns allow acceleration of osteoblast differentiation via macrophage activation
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| Title: | Carbon nanohorns allow acceleration of osteoblast differentiation via macrophage activation |
| Authors: | Hirata, Eri Browse this author | | Miyako, Eijiro Browse this author | | Hanagata, Nobutaka Browse this author →KAKEN DB | | Ushijima, Natsumi Browse this author | | Sakaguchi, Norihito Browse this author →KAKEN DB | | Russier, Julie Browse this author | | Yudasaka, Masako Browse this author →KAKEN DB | | Iijima, Sumio Browse this author | | Bianco, Alberto Browse this author | | Yokoyama, Atsuro Browse this author →KAKEN DB |
| Issue Date: | Aug-2016 |
| Publisher: | Royal Society of Chemistry |
| Journal Title: | Nanoscale |
| Volume: | 8 |
| Issue: | 30 |
| Start Page: | 14514 |
| End Page: | 14522 |
| Publisher DOI: | 10.1039/c6nr02756c |
| PMID: | 27412794 |
| Abstract: | Carbon nanohorns (CNHs), formed by a rolled graphene structure and terminating in a cone, are promising nanomaterials for the development of a variety of biological applications. Here we demonstrate that alkaline phosphatase activity is dramatically increased by coculture of human monocyte derived macrophages (hMDMs) and human mesenchymal stem cells (hMSCs) in the presence of CNHs. CNHs were mainly localized in the lysosome of macrophages more than in hMSCs during coculturing. At the same time, the amount of Oncostatin M (OSM) in the supernatant was also increased during incubation with CNHs. Oncostatin M (OSM) from activated macrophage has been reported to induce osteoblast differentiation and matrix mineralization through STAT3. These results suggest that the macrophages engulfed CNHs and accelerated the differentiation of mesenchymal stem cells into the osteoblast via OSM release. We expect that the proof-of-concept on the osteoblast differentiation capacity by CNHs will allow future studies focused on CNHs as ideal therapeutic materials for bone regeneration. |
| Rights: | https://creativecommons.org/licenses/by/3.0/ |
| Type: | article |
| URI: | http://hdl.handle.net/2115/63383 |
| Appears in Collections: | 歯学院・歯学研究院 (Graduate School of Dental Medicine / Faculty of Dental Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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Submitter: 平田 恵理
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