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Carbon nanohorns allow acceleration of osteoblast differentiation via macrophage activation

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Title: Carbon nanohorns allow acceleration of osteoblast differentiation via macrophage activation
Authors: Hirata, Eri Browse this author
Miyako, Eijiro Browse this author
Hanagata, Nobutaka Browse this author →KAKEN DB
Ushijima, Natsumi Browse this author
Sakaguchi, Norihito Browse this author →KAKEN DB
Russier, Julie Browse this author
Yudasaka, Masako Browse this author →KAKEN DB
Iijima, Sumio Browse this author
Bianco, Alberto Browse this author
Yokoyama, Atsuro Browse this author →KAKEN DB
Issue Date: Aug-2016
Publisher: Royal Society of Chemistry
Journal Title: Nanoscale
Volume: 8
Issue: 30
Start Page: 14514
End Page: 14522
Publisher DOI: 10.1039/c6nr02756c
PMID: 27412794
Abstract: Carbon nanohorns (CNHs), formed by a rolled graphene structure and terminating in a cone, are promising nanomaterials for the development of a variety of biological applications. Here we demonstrate that alkaline phosphatase activity is dramatically increased by coculture of human monocyte derived macrophages (hMDMs) and human mesenchymal stem cells (hMSCs) in the presence of CNHs. CNHs were mainly localized in the lysosome of macrophages more than in hMSCs during coculturing. At the same time, the amount of Oncostatin M (OSM) in the supernatant was also increased during incubation with CNHs. Oncostatin M (OSM) from activated macrophage has been reported to induce osteoblast differentiation and matrix mineralization through STAT3. These results suggest that the macrophages engulfed CNHs and accelerated the differentiation of mesenchymal stem cells into the osteoblast via OSM release. We expect that the proof-of-concept on the osteoblast differentiation capacity by CNHs will allow future studies focused on CNHs as ideal therapeutic materials for bone regeneration.
Type: article
Appears in Collections:歯学院・歯学研究院 (Graduate School of Dental Medicine / Faculty of Dental Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 平田 恵理

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