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Title: 口腔内多発癌の臨床的検討
Other Titles: Clinical study of multiple primary oral cancer
Authors: 足利, 雄一 Browse this author →KAKEN DB
栗林, 和代 Browse this author
大廣, 洋一 Browse this author →KAKEN DB
小野, 貢伸 Browse this author →KAKEN DB
鄭, 漢忠 Browse this author →KAKEN DB
Keywords: Oral cancer
Squamous cell carcinoma
Multiple primary cancer
Issue Date: Sep-2016
Publisher: 北海道歯学会
Journal Title: 北海道歯学雑誌
Volume: 37
Issue: 1
Start Page: 20
End Page: 24
Abstract: 1984年1月から2011年12月までの27年間に当科で治療を行った口腔扁平上皮癌一次症例373例のうち,口腔内多発癌と診断した22例を対象に臨床的検討を行った.発生時期は同時性3例,異時性10例,同・異時性が9例であった.部位別では頰粘膜,下顎歯肉,舌,上顎歯肉に多く発生していた.第1癌から第2癌までの発生間隔は平均80.6か月,第2癌から第3癌までの発生間隔は平均82.5か月であった.治療法は主に手術を主体とした治療が行われていた.局所再発は50.7%,頸部リンパ節転移は59.1%にみられた.病因特異的累積生存率は5年で81.8% であったが,10年では50.3%であった.口腔内多発癌は発生間隔が長いだけでなく,局所再発,リンパ節転移が多いため長期にわたる経過観察が必要であり,早期発見だけではなく,より良い口腔内環境を維持しできるだけ発症を抑制させる様な予防策も念頭において治療を行っていく必要がある.
In this study 22 patients with multiple primary oral cancers (out of 373 oral squamous cell carcinoma) were observed. These patients were treated at Oral Surgery of Hokkaido University Hospital from 1984 to 2011. 3 synchronous, 10 metachronous and 9 synchro-metachronous carcinomas were observed. The buccal mucosa, lower gingiva, tongue, upper gingiva were seen frequently. The mean interval between the first and the second carcinomas was 80.6 months, while that between the second and third carcinomas was 82.5 months.  Surgical treatment was performed for most cases. Local recurrence rate was 50.7% and cervical lymph node metastasis rate was 59.1%. The 5-year and the 10-year disease-specific cumulative survival rate were 81.8% and 50.3%, respectively. The long developmental period, high local recurrence and regional metastasis indicate the necessity of a long term followup and maintenance of good oral environment to inhibit tumor pathogenesis.
Type: article
Appears in Collections:北海道歯学雑誌 = Hokkaido Journal of Dental Science > 第37巻 第1号

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