HUSCAP logo Hokkaido Univ. logo

Hokkaido University Collection of Scholarly and Academic Papers >
水産科学院・水産科学研究院  >
雑誌発表論文等  >

Gonadal soma-derived factor (gsdf), a TGF-beta superfamily gene, induces testis differentiation in the teleost fish Oreochromis niloticus

この資料はクリエイティブ・コモンズ・ライセンスの下で公開されています。

フルテキスト
TilapiaGSDF_Kaneko2.pdf1.66 MBPDF見る/開く
この文献へのリンクには次のURLを使用してください:http://hdl.handle.net/2115/63427

タイトル: Gonadal soma-derived factor (gsdf), a TGF-beta superfamily gene, induces testis differentiation in the teleost fish Oreochromis niloticus
著者: Kaneko, Hiroyo 著作を一覧する
Ijiri, Shigeho 著作を一覧する
Kobayashi, Tohru 著作を一覧する
Izumi, Hikari 著作を一覧する
Kuramochi, Yuki 著作を一覧する
Wang, De-Shou 著作を一覧する
Mizuno, Shouta 著作を一覧する
Nagahama, Yoshitaka 著作を一覧する
キーワード: gsdf
Sex differentiation
Sex determination
dmrt1
Nile tilapia
発行日: 2015年11月 6日
出版者: Elsevier
誌名: Molecular and cellular endocrinology
巻: 415
号: C
開始ページ: 87
終了ページ: 99
出版社 DOI: 10.1016/j.mce.2015.08.008
抄録: The Nile tilapia, Oreochromis niloticus, is a gonochoristic teleost fish with an XX/XY genetic system and is an excellent model for gonadal sex differentiation. In the present study, we screened novel genes that were expressed predominantly in either XY or XX undifferentiated gonads during the critical period for differentiation of gonads into ovaries or testes using microarray screening. We focused on one of the isolated 12 candidate genes, #9475, which was an ortholog of gsdf (gonadal soma-derived factor), a member of the transforming growth factor-beta superfamily. #9475/gsdf showed sexual dimorphism in expression in XY gonads before any other testis differentiation-related genes identified in this species thus far. We also overexpressed the #9475/gsdf gene in)0( tilapia, and XX tilapia bearing the #9475/gsdf gene showed normal testis development, which suggests that #9475/gsdf plays an important role in male determination and/or differentiation in tilapia. (C) 2015 Elsevier Ireland Ltd. All rights reserved.
Rights: © 2015, Elsevier. Licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International http://creativecommons.org/licenses/by-nc-nd/4.0/
資料タイプ: article (author version)
URI: http://hdl.handle.net/2115/63427
出現コレクション:雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

提供者: 井尻 成保

 

本サイトに関するご意見・お問い合わせは repo at lib.hokudai.ac.jp へお願いします。 - 北海道大学