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Gonadal soma-derived factor (gsdf), a TGF-beta superfamily gene, induces testis differentiation in the teleost fish Oreochromis niloticus
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Title: | Gonadal soma-derived factor (gsdf), a TGF-beta superfamily gene, induces testis differentiation in the teleost fish Oreochromis niloticus |
Authors: | Kaneko, Hiroyo Browse this author | Ijiri, Shigeho Browse this author →KAKEN DB | Kobayashi, Tohru Browse this author | Izumi, Hikari Browse this author | Kuramochi, Yuki Browse this author | Wang, De-Shou Browse this author | Mizuno, Shouta Browse this author | Nagahama, Yoshitaka Browse this author |
Keywords: | gsdf | Sex differentiation | Sex determination | dmrt1 | Nile tilapia |
Issue Date: | 6-Nov-2015 |
Publisher: | Elsevier |
Journal Title: | Molecular and cellular endocrinology |
Volume: | 415 |
Issue: | C |
Start Page: | 87 |
End Page: | 99 |
Publisher DOI: | 10.1016/j.mce.2015.08.008 |
PMID: | 26265450 |
Abstract: | The Nile tilapia, Oreochromis niloticus, is a gonochoristic teleost fish with an XX/XY genetic system and is an excellent model for gonadal sex differentiation. In the present study, we screened novel genes that were expressed predominantly in either XY or XX undifferentiated gonads during the critical period for differentiation of gonads into ovaries or testes using microarray screening. We focused on one of the isolated 12 candidate genes, #9475, which was an ortholog of gsdf (gonadal soma-derived factor), a member of the transforming growth factor-beta superfamily. #9475/gsdf showed sexual dimorphism in expression in XY gonads before any other testis differentiation-related genes identified in this species thus far. We also overexpressed the #9475/gsdf gene in)0( tilapia, and XX tilapia bearing the #9475/gsdf gene showed normal testis development, which suggests that #9475/gsdf plays an important role in male determination and/or differentiation in tilapia. (C) 2015 Elsevier Ireland Ltd. All rights reserved. |
Rights: | © 2015, Elsevier. Licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International http://creativecommons.org/licenses/by-nc-nd/4.0/ | http://creativecommons.org/licenses/by-nc-nd/4.0/ |
Type: | article (author version) |
URI: | http://hdl.handle.net/2115/63427 |
Appears in Collections: | 水産科学院・水産科学研究院 (Graduate School of Fisheries Sciences / Faculty of Fisheries Sciences) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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Submitter: 井尻 成保
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