HUSCAP logo Hokkaido Univ. logo

Hokkaido University Collection of Scholarly and Academic Papers >
Graduate School of Fisheries Sciences / Faculty of Fisheries Sciences >
Peer-reviewed Journal Articles, etc >

Gonadal soma-derived factor (gsdf), a TGF-beta superfamily gene, induces testis differentiation in the teleost fish Oreochromis niloticus

This item is licensed under: Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International

Files in This Item:
TilapiaGSDF_Kaneko2.pdf1.66 MBPDFView/Open
Please use this identifier to cite or link to this item:http://hdl.handle.net/2115/63427

Title: Gonadal soma-derived factor (gsdf), a TGF-beta superfamily gene, induces testis differentiation in the teleost fish Oreochromis niloticus
Authors: Kaneko, Hiroyo Browse this author
Ijiri, Shigeho Browse this author →KAKEN DB
Kobayashi, Tohru Browse this author
Izumi, Hikari Browse this author
Kuramochi, Yuki Browse this author
Wang, De-Shou Browse this author
Mizuno, Shouta Browse this author
Nagahama, Yoshitaka Browse this author
Keywords: gsdf
Sex differentiation
Sex determination
dmrt1
Nile tilapia
Issue Date: 6-Nov-2015
Publisher: Elsevier
Journal Title: Molecular and cellular endocrinology
Volume: 415
Issue: C
Start Page: 87
End Page: 99
Publisher DOI: 10.1016/j.mce.2015.08.008
PMID: 26265450
Abstract: The Nile tilapia, Oreochromis niloticus, is a gonochoristic teleost fish with an XX/XY genetic system and is an excellent model for gonadal sex differentiation. In the present study, we screened novel genes that were expressed predominantly in either XY or XX undifferentiated gonads during the critical period for differentiation of gonads into ovaries or testes using microarray screening. We focused on one of the isolated 12 candidate genes, #9475, which was an ortholog of gsdf (gonadal soma-derived factor), a member of the transforming growth factor-beta superfamily. #9475/gsdf showed sexual dimorphism in expression in XY gonads before any other testis differentiation-related genes identified in this species thus far. We also overexpressed the #9475/gsdf gene in)0( tilapia, and XX tilapia bearing the #9475/gsdf gene showed normal testis development, which suggests that #9475/gsdf plays an important role in male determination and/or differentiation in tilapia. (C) 2015 Elsevier Ireland Ltd. All rights reserved.
Rights: © 2015, Elsevier. Licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International http://creativecommons.org/licenses/by-nc-nd/4.0/
http://creativecommons.org/licenses/by-nc-nd/4.0/
Type: article (author version)
URI: http://hdl.handle.net/2115/63427
Appears in Collections:水産科学院・水産科学研究院 (Graduate School of Fisheries Sciences / Faculty of Fisheries Sciences) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 井尻 成保

Export metadata:

OAI-PMH ( junii2 , jpcoar )

MathJax is now OFF:


 

 - Hokkaido University