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Oral administration of the Aureobasidium pullulans-derived β-glucan effectively prevents the development of high fat diet-induced fatty liver in mice
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| Title: | Oral administration of the Aureobasidium pullulans-derived β-glucan effectively prevents the development of high fat diet-induced fatty liver in mice |
| Authors: | Aoki, Shiho Browse this author | | Iwai, Atsushi Browse this author | | Kawata, Koji Browse this author | | Muramatsu, Daisuke Browse this author | | Uchiyama, Hirofumi Browse this author | | Okabe, Mitsuyasu Browse this author | | Ikesue, Masahiro Browse this author | | Maeda, Naoyoshi Browse this author | | Uede, Toshimitsu Browse this author →KAKEN DB |
| Issue Date: | 16-Jul-2015 |
| Publisher: | Nature Publishing |
| Journal Title: | Scientific Reports |
| Volume: | 5 |
| Start Page: | 10457 |
| Publisher DOI: | 10.1038/srep10457 |
| PMID: | 26179949 |
| Abstract: | Aureobasidium pullulans-derived β-glucan (AP-PG) consisting of a β-(1,3)-linked glucose main chain and β-(1,6)-linked glucose branches is taken as a supplement to improve health. This study demonstrates that oral administration of AP-PG is effective to prevent the development of high-fat diet (HFD)-induced fatty liver in mice. Here, C57BL/6N mice were fed with a normal diet or HFD, and AP-PG diluted in drinking water was administered orally. After 16 weeks, the serological analysis showed that HFD-induced high blood cholesterol and triglyceride levels were reduced by the oral administration of AP-PG. Further, HFD induced-fatty liver was significantly reduced by the oral administration of AP-PG. The triglyceride accumulation in the liver was also significantly reduced in mice administered AP-PG. Liver injury as indicated by an increase in serum alanine aminotransferase (ALT) in the HFD-fed mice was significantly reduced in the mice administered AP-PG orally, and the gene expression of cholesterol 7 alpha-hydroxylase (CYP7A1) which is known to be involved in cholesterol degradation in the liver was significantly increased in the AP-PG administered mice. These results suggest the possibility that the oral administration of AP-PG is effective to prevent the development of non-alcoholic fatty liver disease (NAFLD). |
| Rights: | https://creativecommons.org/licenses/by/4.0/ |
| Type: | article |
| URI: | http://hdl.handle.net/2115/63469 |
| Appears in Collections: | 遺伝子病制御研究所 (Institute for Genetic Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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Submitter: 岩井 淳
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