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Oral administration of the Aureobasidium pullulans-derived β-glucan effectively prevents the development of high fat diet-induced fatty liver in mice

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タイトル: Oral administration of the Aureobasidium pullulans-derived β-glucan effectively prevents the development of high fat diet-induced fatty liver in mice
著者: Aoki, Shiho 著作を一覧する
Iwai, Atsushi 著作を一覧する
Kawata, Koji 著作を一覧する
Muramatsu, Daisuke 著作を一覧する
Uchiyama, Hirofumi 著作を一覧する
Okabe, Mitsuyasu 著作を一覧する
Ikesue, Masahiro 著作を一覧する
Maeda, Naoyoshi 著作を一覧する
Uede, Toshimitsu 著作を一覧する
発行日: 2015年 7月16日
出版者: Nature Publishing
誌名: Scientific Reports
巻: 5
開始ページ: 10457
出版社 DOI: 10.1038/srep10457
抄録: Aureobasidium pullulans-derived β-glucan (AP-PG) consisting of a β-(1,3)-linked glucose main chain and β-(1,6)-linked glucose branches is taken as a supplement to improve health. This study demonstrates that oral administration of AP-PG is effective to prevent the development of high-fat diet (HFD)-induced fatty liver in mice. Here, C57BL/6N mice were fed with a normal diet or HFD, and AP-PG diluted in drinking water was administered orally. After 16 weeks, the serological analysis showed that HFD-induced high blood cholesterol and triglyceride levels were reduced by the oral administration of AP-PG. Further, HFD induced-fatty liver was significantly reduced by the oral administration of AP-PG. The triglyceride accumulation in the liver was also significantly reduced in mice administered AP-PG. Liver injury as indicated by an increase in serum alanine aminotransferase (ALT) in the HFD-fed mice was significantly reduced in the mice administered AP-PG orally, and the gene expression of cholesterol 7 alpha-hydroxylase (CYP7A1) which is known to be involved in cholesterol degradation in the liver was significantly increased in the AP-PG administered mice. These results suggest the possibility that the oral administration of AP-PG is effective to prevent the development of non-alcoholic fatty liver disease (NAFLD).
資料タイプ: article
URI: http://hdl.handle.net/2115/63469
出現コレクション:雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

提供者: 岩井 淳

 

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