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Quantitative evaluation of gait ataxia by accelerometers

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タイトル: Quantitative evaluation of gait ataxia by accelerometers
著者: Shirai, Shinichi 著作を一覧する
Yabe, Ichiro 著作を一覧する
Matsushima, Masaaki 著作を一覧する
Ito, Yoichi M. 著作を一覧する
Yoneyama, Mitsuru 著作を一覧する
Sasaki, Hidenao 著作を一覧する
キーワード: cerebellar ataxia
quantitative evaluation
accelerometer
biomarker
the Scale for the Assessment and Rating of Ataxia (SARA)
gait analysis
発行日: 2015年11月15日
出版者: Elsevier
誌名: Journal of the Neurological Sciences
巻: 358
号: 1-2
開始ページ: 253
終了ページ: 258
出版社 DOI: 10.1016/j.jns.2015.09.004
抄録: An appropriate biomarker for spinocerebellar degeneration (SCD) has not been identified. Here, we performed gait analysis on patients with pure cerebellar type SCD and assessed whether the obtained data could be used as a neurophysiological biomarker for cerebellar ataxia. We analyzed 25 SCD patients, 25 patients with Parkinson's disease as a disease control, and 25 healthy control individuals. Acceleration signals during 6 min of walking and 1 min of standing were measured by two sets of triaxial accelerometers that were secured with a fixation vest to the middle of the lower and upper back of each subject. We extracted two gait parameters, the average and the coefficient of variation of motion trajectory amplitude, from each acceleration component. Then, each component was analyzed by correlation with the Scale for the Assessment and Rating of Ataxia (SARA) and the Berg Balance Scale (BBS). Compared with the gait control of healthy subjects and concerning correlation with severity and disease specificity, our results suggest that the average amplitude of medial-lateral (upper back) of straight gait is a physiological biomarker for cerebellar ataxia. Our results suggest that gait analysis is a quantitative and concise evaluation scale for the severity of cerebellar ataxia.
Rights: © 2015. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/
資料タイプ: article (author version)
URI: http://hdl.handle.net/2115/63578
出現コレクション:雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

提供者: 矢部 一郎

 

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