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Spatiotemporal control of kinesin motor protein by photoswitches enabling selective single microtubule regulations

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Title: Spatiotemporal control of kinesin motor protein by photoswitches enabling selective single microtubule regulations
Authors: Kumar, K. R. Sunil Browse this author
Amrutha, Ammathnadu S. Browse this author
Tamaoki, Nobuyuki Browse this author →KAKEN DB
Issue Date: 21-Dec-2016
Publisher: The Royal Society of Chemistry
Journal Title: Lab on a Chip
Volume: 16
Issue: 24
Start Page: 4702
End Page: 4709
Publisher DOI: 10.1039/C6LC01098A
PMID: 27785507
Abstract: Artificial control of bio-nanomachines should have a major impact on the development of controllable transport systems for specific cargo transport on chips. Precise spatiotemporal control and local regulation of the bio-motor activity will, however, be necessary if we are to accomplish such a goal. In this study, we exploited the photoswitching properties of azobenzene-based high-energy molecules and inhibitors to control a single kinesin-driven microtubule that has potential to work as a nanocarrier for molecular cargos. In particular, we could influence the local concentration and dispersion of the microtubules at any desired position and time by irradiating a local area of the motility system at one wavelength, while irradiating the entire area at another wavelength, to enrich either cis or trans isomers of photoswitches in the selected region. Furthermore, various regulations (e.g., transporting, bending, breaking) of single microtubules were possible while almost arresting ambient microtubules—all without the need for any surface patterning.
Rights: http://creativecommons.org/licenses/by/3.0/
Type: article
URI: http://hdl.handle.net/2115/63687
Appears in Collections:電子科学研究所 (Research Institute for Electronic Science) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 玉置 信之

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