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Spatiotemporal control of kinesin motor protein by photoswitches enabling selective single microtubule regulations

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タイトル: Spatiotemporal control of kinesin motor protein by photoswitches enabling selective single microtubule regulations
著者: Kumar, K. R. Sunil 著作を一覧する
Amrutha, Ammathnadu S. 著作を一覧する
Tamaoki, Nobuyuki 著作を一覧する
発行日: 2016年12月21日
出版者: The Royal Society of Chemistry
誌名: Lab on a Chip
巻: 16
号: 24
開始ページ: 4702
終了ページ: 4709
出版社 DOI: 10.1039/C6LC01098A
抄録: Artificial control of bio-nanomachines should have a major impact on the development of controllable transport systems for specific cargo transport on chips. Precise spatiotemporal control and local regulation of the bio-motor activity will, however, be necessary if we are to accomplish such a goal. In this study, we exploited the photoswitching properties of azobenzene-based high-energy molecules and inhibitors to control a single kinesin-driven microtubule that has potential to work as a nanocarrier for molecular cargos. In particular, we could influence the local concentration and dispersion of the microtubules at any desired position and time by irradiating a local area of the motility system at one wavelength, while irradiating the entire area at another wavelength, to enrich either cis or trans isomers of photoswitches in the selected region. Furthermore, various regulations (e.g., transporting, bending, breaking) of single microtubules were possible while almost arresting ambient microtubules—all without the need for any surface patterning.
資料タイプ: article
URI: http://hdl.handle.net/2115/63687
出現コレクション:雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

提供者: 玉置 信之

 

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