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Antitumour activity of EPA-enriched phospholipids liposomes against S180 ascitic tumour-bearing mice

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Title: Antitumour activity of EPA-enriched phospholipids liposomes against S180 ascitic tumour-bearing mice
Authors: Du, Lei Browse this author
Yang, Yu-Hong Browse this author
Wang, Yu-Ming Browse this author
Xue, Chang-Hu Browse this author
Kurihara, Hideyuki Browse this author
Takahashi, Koretaro Browse this author →KAKEN DB
Keywords: EPA-enriched phospholipids
S180 ascitic tumour
Mitochondrial apoptotic pathways
Issue Date: Dec-2015
Publisher: Elsevier
Journal Title: Journal of functional foods
Volume: 19
Start Page: 970
End Page: 982
Publisher DOI: 10.1016/j.jff.2015.06.061
Abstract: The health benefits of eicosapentaenoic acid (EPA)-enriched phospholipids (PL) have witnessed a recent upsurge. In the present study, PL from starfish Asterias amurensis (SFP) and sea cucumber Cucumaria frondosa (SCP) were extracted and the liposomes were prepared. Both SFP and SCP liposomes showed antitumour effects in vitro and exhibited high transport and uptake effects in small intestinal epithelial cell models. The results also demonstrated that dietary SFP and SCP liposomes prolonged the life span and ameliorated oxidative stress status of S180 ascitic tumour-bearing mice. Results also showed that dietary SFP and SCP liposomes up-regulated the expression of Bax and down-regulated Bcl-2 level in tumour cells, then induced release of cytochrome c from mitochondria to cytosol, thus the activation of caspase 9 and caspase 3. Taken together, these findings suggest that SFP and SCP liposomes exert antitumour effects mainly via activation of mitochondrial apoptotic pathways in tumour-bearing mice. (C) 2015 Elsevier Ltd. All rights reserved.
Rights: © 2015, Elsevier. Licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International
Type: article (author version)
Appears in Collections:水産科学院・水産科学研究院 (Graduate School of Fisheries Sciences / Faculty of Fisheries Sciences) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 高橋 是太郎

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