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Antitumour activity of EPA-enriched phospholipids liposomes against S180 ascitic tumour-bearing mice
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Title: | Antitumour activity of EPA-enriched phospholipids liposomes against S180 ascitic tumour-bearing mice |
Authors: | Du, Lei Browse this author | Yang, Yu-Hong Browse this author | Wang, Yu-Ming Browse this author | Xue, Chang-Hu Browse this author | Kurihara, Hideyuki Browse this author | Takahashi, Koretaro Browse this author →KAKEN DB |
Keywords: | EPA-enriched phospholipids | Liposomes | S180 ascitic tumour | Antioxidant | Mitochondrial apoptotic pathways |
Issue Date: | Dec-2015 |
Publisher: | Elsevier |
Journal Title: | Journal of functional foods |
Volume: | 19 |
Start Page: | 970 |
End Page: | 982 |
Publisher DOI: | 10.1016/j.jff.2015.06.061 |
Abstract: | The health benefits of eicosapentaenoic acid (EPA)-enriched phospholipids (PL) have witnessed a recent upsurge. In the present study, PL from starfish Asterias amurensis (SFP) and sea cucumber Cucumaria frondosa (SCP) were extracted and the liposomes were prepared. Both SFP and SCP liposomes showed antitumour effects in vitro and exhibited high transport and uptake effects in small intestinal epithelial cell models. The results also demonstrated that dietary SFP and SCP liposomes prolonged the life span and ameliorated oxidative stress status of S180 ascitic tumour-bearing mice. Results also showed that dietary SFP and SCP liposomes up-regulated the expression of Bax and down-regulated Bcl-2 level in tumour cells, then induced release of cytochrome c from mitochondria to cytosol, thus the activation of caspase 9 and caspase 3. Taken together, these findings suggest that SFP and SCP liposomes exert antitumour effects mainly via activation of mitochondrial apoptotic pathways in tumour-bearing mice. (C) 2015 Elsevier Ltd. All rights reserved. |
Rights: | © 2015, Elsevier. Licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International http://creativecommons.org/licenses/by-nc-nd/4.0/ | http://creativecommons.org/licenses/by-nc-nd/4.0/ |
Type: | article (author version) |
URI: | http://hdl.handle.net/2115/63704 |
Appears in Collections: | 水産科学院・水産科学研究院 (Graduate School of Fisheries Sciences / Faculty of Fisheries Sciences) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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Submitter: 高橋 是太郎
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