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Clinical outcomes of weekly cisplatin chemoradiotherapy for patients with pyriform sinus cancer

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Title: Clinical outcomes of weekly cisplatin chemoradiotherapy for patients with pyriform sinus cancer
Authors: Sakashita, Tomohiro Browse this author →KAKEN DB
Homma, Akihiro Browse this author →KAKEN DB
Hatakeyama, Hiromitsu Browse this author →KAKEN DB
Furusawa, Jun Browse this author
Kano, Satoshi Browse this author →KAKEN DB
Mizumachi, Takatsugu Browse this author →KAKEN DB
Iizuka, Satoshi Browse this author
Onimaru, Rikiya Browse this author →KAKEN DB
Tsuchiya, Kazuhiko Browse this author →KAKEN DB
Yasuda, Koichi Browse this author →KAKEN DB
Shirato, Hiroki Browse this author →KAKEN DB
Fukuda, Satoshi Browse this author →KAKEN DB
Keywords: Chemoradiation
Hypopharyngeal cancer
Laryngeal preservation
Issue Date: Dec-2015
Publisher: Springer
Journal Title: International Journal of Clinical Oncology
Volume: 20
Issue: 6
Start Page: 1081
End Page: 1085
Publisher DOI: 10.1007/s10147-015-0821-8
PMID: 25804347
Abstract: Background: Pyriform sinus squamous cell carcinoma (SCC) has one of the worst prognoses of all upper aerodigestive tract cancers. Improving clinical outcomes for patients with hypopharyngeal SCC has been particularly challenging for head and neck surgeons and oncologists. Methods: We investigated 30 patients with pyriform sinus SCC to verify the effectiveness of weekly cisplatin chemotherapy with concurrent radiotherapy. Cisplatin was administered at a dose of 40 mg/m2 on weeks 1, 2, 3, 5, 6, and 7 during definitive radiotherapy with the aim of preserving the larynx. Results: All 30 patients achieved definitive radiotherapy at a median dose of 70 Gy (range 64-70 Gy). Cisplatin was administrated concomitantly a median of five times (range 2-6 times). Persistent or recurrent primary disease was observed in four patients (13 %). Persistent or recurrent nodal metastasis was observed in five patients (17 %). Nine salvage surgeries were performed for eight patients, of whom seven survived without any evidence of disease. Post-operative complications were observed in two patients (22 %). The 5-year overall survival and locoregional control rates were 87 and 96 %, respectively. The 5-year laryngeal preservation rate was 74 %. Conclusions: The regimen of weekly cisplatin CRT may be effective for pyriform sinus SCC; however, there were problems with strong selection bias in the current study due to the large number of T2 patients. Salvage surgery was safe and was able to improve the survival rate. This chemoradiation regimen was considered successful in preserving laryngeal function.
Rights: The final publication is available at Springer via
Type: article (author version)
Appears in Collections:医学院・医学研究院 (Graduate School of Medicine / Faculty of Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
国際連携研究教育局 : GI-CoRE (Global Institution for Collaborative Research and Education : GI-CoRE) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 坂下 智博

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