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Hokkaido University Collection of Scholarly and Academic Papers >
Graduate School of Medicine / Faculty of Medicine >
Peer-reviewed Journal Articles, etc >
Immunohistochemical localization of fatty acid transporters and MCT1 in the sebaceous glands of mouse skin
| Title: | Immunohistochemical localization of fatty acid transporters and MCT1 in the sebaceous glands of mouse skin |
| Authors: | Zheng, Miao Browse this author | | Lee, Shinhye Browse this author | | Tsuzuki, Satoshi Browse this author →KAKEN DB | | Inoue, Kazuo Browse this author →KAKEN DB | | Masuda, Daisaku Browse this author →KAKEN DB | | Yamashita, Shizuya Browse this author →KAKEN DB | | Iwanaga, Toshihiko Browse this author →KAKEN DB |
| Issue Date: | 2016 |
| Publisher: | Biomedical Research Press |
| Journal Title: | Biomedical Research |
| Volume: | 37 |
| Issue: | 4 |
| Start Page: | 265 |
| End Page: | 270 |
| Publisher DOI: | 10.2220/biomedres.37.265 |
| PMID: | 27545003 |
| Abstract: | The sebaceous glands secrete sebum to protect the epidermis and hairs by the oily products. The glands express several transporters and binding proteins for the production of fatty acids and uptake of their sources. The present immunohistochemical study examined the expression and localization of CD36, MCT1, FATP4, and E-FABP in the sebaceous glands, including the meibomian and preputial glands of mice. CD36 and MCT1 in sebaceous glands were largely co-localized along the plasma membrane of secretory cells, while they were separately expressed in the glandular portion of meibomian and preputial glands. Immunoreactivities for FATP4 and E-FABP appeared diffusely in the cytoplasm of secretory cells. Genetic deletion of CD36 did not affect the immunolocalization of the three other molecules. The sebaceous glands were judged to be useful for analyzing the functions and relation of fatty acid transporters and binding proteins. |
| Type: | article |
| URI: | http://hdl.handle.net/2115/63748 |
| Appears in Collections: | 医学院・医学研究院 (Graduate School of Medicine / Faculty of Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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Submitter: 岩永 敏彦
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