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Immunohistochemical localization of fatty acid transporters and MCT1 in the sebaceous glands of mouse skin

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Title: Immunohistochemical localization of fatty acid transporters and MCT1 in the sebaceous glands of mouse skin
Authors: Zheng, Miao Browse this author
Lee, Shinhye Browse this author
Tsuzuki, Satoshi Browse this author →KAKEN DB
Inoue, Kazuo Browse this author →KAKEN DB
Masuda, Daisaku Browse this author →KAKEN DB
Yamashita, Shizuya Browse this author →KAKEN DB
Iwanaga, Toshihiko Browse this author →KAKEN DB
Issue Date: 2016
Publisher: Biomedical Research Press
Journal Title: Biomedical Research
Volume: 37
Issue: 4
Start Page: 265
End Page: 270
Publisher DOI: 10.2220/biomedres.37.265
PMID: 27545003
Abstract: The sebaceous glands secrete sebum to protect the epidermis and hairs by the oily products. The glands express several transporters and binding proteins for the production of fatty acids and uptake of their sources. The present immunohistochemical study examined the expression and localization of CD36, MCT1, FATP4, and E-FABP in the sebaceous glands, including the meibomian and preputial glands of mice. CD36 and MCT1 in sebaceous glands were largely co-localized along the plasma membrane of secretory cells, while they were separately expressed in the glandular portion of meibomian and preputial glands. Immunoreactivities for FATP4 and E-FABP appeared diffusely in the cytoplasm of secretory cells. Genetic deletion of CD36 did not affect the immunolocalization of the three other molecules. The sebaceous glands were judged to be useful for analyzing the functions and relation of fatty acid transporters and binding proteins.
Type: article
Appears in Collections:医学院・医学研究院 (Graduate School of Medicine / Faculty of Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 岩永 敏彦

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