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Volume 64 Number 4 >

Usefulness of an anesthetic mixture of medetomidine, midazolam, and butorphanol in cotton rats (Sigmodon hispidus)

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Title: Usefulness of an anesthetic mixture of medetomidine, midazolam, and butorphanol in cotton rats (Sigmodon hispidus)
Authors: Nakamura, Teppei Browse this author
Ichii, Osamu Browse this author →KAKEN DB
Irie, Takao Browse this author
Hosotani, Marina Browse this author
Dantsuka, Ai Browse this author
Nakamura, Saori Browse this author
Sato, Shinobu Browse this author
Sotozaki, Kozue Browse this author
Kouguchi, Hirokazu Browse this author →KAKEN DB
Yoshiyasu, Tomoji Browse this author
Nagasaki, Ken-ichi Browse this author
Kon, Yasuhiro Browse this author →KAKEN DB
Keywords: anesthesia
cotton rat
Issue Date: Nov-2016
Publisher: Graduate School of Veterinary Medicine, Hokkaido University
Journal Title: Japanese Journal of Veterinary Research
Volume: 64
Issue: 4
Start Page: 273
End Page: 276
Abstract: The cotton rat (Sigmodon hispidus) is a laboratory rodent used for studying human infectious diseases. However, a lack of suitable anesthetic agents inconveniences the use of cotton rats in surgical manipulation. This study demonstrated that subcutaneous injection of the mixture of medetomidine, midazolam, and butorphanol (0.15, 2.0, and 2.5 mg/kg, respectively), which is a suitable anesthetic agents for mice and rats, produced an anesthetic duration of more than 50 min in cotton rats. We also demonstrated that 0.15 mg/kg of atipamezole, an antagonist of medetomidine, produced a quick recovery from anesthesia in cotton rats. This indicated that the anesthetic mixture of medetomidine, midazolam, and butorphanol, functioned as a useful and effective anesthetic for short-term surgery in cotton rats.
Type: bulletin (article)
Appears in Collections:Japanese Journal of Veterinary Research > Volume 64 Number 4

Submitter: 獣医学部図書室

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