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Volume 64 Number 4 >

Does the routine handling affect the phenotype of disease model mice?

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Title: Does the routine handling affect the phenotype of disease model mice?
Authors: Ono, Maiko Browse this author
Sasaki, Hayato Browse this author
Nagasaki, Kenichi Browse this author
Torigoe, Daisuke Browse this author
Ichii, Osamu Browse this author →KAKEN DB
Sasaki, Nobuya Browse this author →KAKEN DB
Agui, Takashi Browse this author →KAKEN DB
Keywords: handling
Issue Date: Nov-2016
Publisher: Graduate School of Veterinary Medicine, Hokkaido University
Journal Title: Japanese Journal of Veterinary Research
Volume: 64
Issue: 4
Start Page: 265
End Page: 271
Abstract: The three different mouse handling methods, picking up by tails, tunnels, and open hands were performed using the ICGN glomerulonephritis mouse and the severity of symptoms was evaluated. The handling groups exhibited a tendency of more severe symptoms than the non-handling control group. Female mice handled by their tails showed significantly more severe symptoms than the control group. In addition, we subjected the normal laboratory mice, C57BL/6 and BALB/c mice to tail and tunnel handling to assess the stress conditions. The plasma corticosterone level in the tail-handled mice was higher than that in control mice. These results indicate that handling causes stress and may affect the phenotype of disease model mice.
Type: bulletin (article)
Appears in Collections:Japanese Journal of Veterinary Research > Volume 64 Number 4

Submitter: 獣医学部図書室

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