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Japanese Journal of Veterinary Research >
Volume 64 Number 4 >

Does the routine handling affect the phenotype of disease model mice?

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タイトル: Does the routine handling affect the phenotype of disease model mice?
著者: Ono, Maiko 著作を一覧する
Sasaki, Hayato 著作を一覧する
Nagasaki, Kenichi 著作を一覧する
Torigoe, Daisuke 著作を一覧する
Ichii, Osamu 著作を一覧する
Sasaki, Nobuya 著作を一覧する
Agui, Takashi 著作を一覧する
キーワード: handling
発行日: 2016年11月
出版者: Graduate School of Veterinary Medicine, Hokkaido University
誌名: Japanese Journal of Veterinary Research
巻: 64
号: 4
開始ページ: 265
終了ページ: 271
抄録: The three different mouse handling methods, picking up by tails, tunnels, and open hands were performed using the ICGN glomerulonephritis mouse and the severity of symptoms was evaluated. The handling groups exhibited a tendency of more severe symptoms than the non-handling control group. Female mice handled by their tails showed significantly more severe symptoms than the control group. In addition, we subjected the normal laboratory mice, C57BL/6 and BALB/c mice to tail and tunnel handling to assess the stress conditions. The plasma corticosterone level in the tail-handled mice was higher than that in control mice. These results indicate that handling causes stress and may affect the phenotype of disease model mice.
資料タイプ: bulletin (article)
出現コレクション:Volume 64 Number 4

提供者: 獣医学部図書室


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