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Volume 64 Number 4 >

Regulation of p16 gene expression by histone H3 acetylation in canine lymphoid tumor cell lines

039.257-263 NOTE FUJIWARA-IGARASHI.pdf483.62 kBPDF見る/開く

タイトル: Regulation of p16 gene expression by histone H3 acetylation in canine lymphoid tumor cell lines
著者: Fujiwara-Igarashi, Aki 著作を一覧する
Tomiyasu, Hirotaka 著作を一覧する
Igarashi, Hirotaka 著作を一覧する
Yu, Yoshihiko 著作を一覧する
Goto-Koshino, Yuko 著作を一覧する
Ohno, Koichi 著作を一覧する
Tsujimoto, Hajime 著作を一覧する
キーワード: canine lymphoid tumor
histone H3 acetylation
発行日: 2016年11月
出版者: Graduate School of Veterinary Medicine, Hokkaido University
誌名: Japanese Journal of Veterinary Research
巻: 64
号: 4
開始ページ: 257
終了ページ: 263
抄録: In order to investigate whether suppression of the p16 gene is mediated by histone H3 acetylation in 4 canine lymphoid tumor cell lines, the gene’s acetylation status was examined. In 2 canine lymphoid tumor cell lines with low p16 mRNA expression (GL-1 and UL-1), the acetylation level was lower than that in CL-1 cells with high p16 mRNA expression. The expression of the p16 gene in these 2 cell lines was markedly restored after culture in the presence of a histone deacetylase inhibitors trichostatin A, indicating that p16 was inactivated by hypoacetylation. Findings obtained this study will add new insights and lead to the better understanding of the disease pathogenesis and future development of epigenetic therapeutic strategies.
資料タイプ: bulletin (article)
出現コレクション:Volume 64 Number 4


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