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Regulation of p16 gene expression by histone H3 acetylation in canine lymphoid tumor cell lines

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Title: Regulation of p16 gene expression by histone H3 acetylation in canine lymphoid tumor cell lines
Authors: Fujiwara-Igarashi, Aki Browse this author
Tomiyasu, Hirotaka Browse this author
Igarashi, Hirotaka Browse this author
Yu, Yoshihiko Browse this author
Goto-Koshino, Yuko Browse this author
Ohno, Koichi Browse this author →KAKEN DB
Tsujimoto, Hajime Browse this author →KAKEN DB
Keywords: canine lymphoid tumor
histone H3 acetylation
Issue Date: Nov-2016
Publisher: Graduate School of Veterinary Medicine, Hokkaido University
Journal Title: Japanese Journal of Veterinary Research
Volume: 64
Issue: 4
Start Page: 257
End Page: 263
Abstract: In order to investigate whether suppression of the p16 gene is mediated by histone H3 acetylation in 4 canine lymphoid tumor cell lines, the gene’s acetylation status was examined. In 2 canine lymphoid tumor cell lines with low p16 mRNA expression (GL-1 and UL-1), the acetylation level was lower than that in CL-1 cells with high p16 mRNA expression. The expression of the p16 gene in these 2 cell lines was markedly restored after culture in the presence of a histone deacetylase inhibitors trichostatin A, indicating that p16 was inactivated by hypoacetylation. Findings obtained this study will add new insights and lead to the better understanding of the disease pathogenesis and future development of epigenetic therapeutic strategies.
Type: bulletin (article)
Appears in Collections:Japanese Journal of Veterinary Research > Volume 64 Number 4

Submitter: 獣医学部図書室

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