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Inhibition of algal bromophenols and their related phenols against glucose 6-phosphate dehydrogenase
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| Title: | Inhibition of algal bromophenols and their related phenols against glucose 6-phosphate dehydrogenase |
| Authors: | Mikami, Daisuke Browse this author | | Kurihara, Hideyuki Browse this author →KAKEN DB | | Ono, Momoka Browse this author | | Kim, Sang Moo Browse this author | | Takahashi, Koretaro Browse this author →KAKEN DB |
| Keywords: | Glucose 6-phosphate dehydrogenase | | Inhibition | | Bromophenol | | Polyphenol | | Alga |
| Issue Date: | Jan-2016 |
| Publisher: | Elsevier |
| Journal Title: | Fitoterapia |
| Volume: | 108 |
| Start Page: | 20 |
| End Page: | 25 |
| Publisher DOI: | 10.1016/j.fitote.2015.11.002 |
| PMID: | 26586619 |
| Abstract: | A novel bromophenol, n-butyl 2,3-dibromo-4,5-dihydroxybenzyl ether, and known bromophenols were isolated from Rhodomelaceae algae as glucose 6-phosphate dehydrogenase (G6PD) inhibitors. Among them, bromophenol dimers showed stronger inhibitory activity against Leuconostoc mesenteroides and Saccharomyces cerevisiae G6PDs than the corresponding monomers. The dibenzyl ether-type dimers had lower IC50 values than the diarylmethane-type dimers against L. mesenteroides G6PD among the bromophenols examined. In contrast, the inhibitory activities of diarylmethane-type dimers against S. cerevisiae G6PD were stronger than those of dibenzyl ether-type dimers. Especially, 3-bromo-2-(2,3-dibromo-4,5-dihydroxybenzyI)-4,5-dihydroxybenzyl methyl ether selectively inhibited S. cerevisiae G6PD compared to L mesenteroides G6PD. (C) 2015 Elsevier B.V. All rights reserved. |
| Rights: | © 2016, Elsevier. Licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International http://creativecommons.org/licenses/by-nc-nd/4.0/ | | http://creativecommons.org/licenses/by-nc-nd/4.0/ |
| Type: | article (author version) |
| URI: | http://hdl.handle.net/2115/63940 |
| Appears in Collections: | 水産科学院・水産科学研究院 (Graduate School of Fisheries Sciences / Faculty of Fisheries Sciences) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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Submitter: 栗原 秀幸
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