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Inhibition of algal bromophenols and their related phenols against glucose 6-phosphate dehydrogenase

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Title: Inhibition of algal bromophenols and their related phenols against glucose 6-phosphate dehydrogenase
Authors: Mikami, Daisuke Browse this author
Kurihara, Hideyuki Browse this author →KAKEN DB
Ono, Momoka Browse this author
Kim, Sang Moo Browse this author
Takahashi, Koretaro Browse this author →KAKEN DB
Keywords: Glucose 6-phosphate dehydrogenase
Issue Date: Jan-2016
Publisher: Elsevier
Journal Title: Fitoterapia
Volume: 108
Start Page: 20
End Page: 25
Publisher DOI: 10.1016/j.fitote.2015.11.002
PMID: 26586619
Abstract: A novel bromophenol, n-butyl 2,3-dibromo-4,5-dihydroxybenzyl ether, and known bromophenols were isolated from Rhodomelaceae algae as glucose 6-phosphate dehydrogenase (G6PD) inhibitors. Among them, bromophenol dimers showed stronger inhibitory activity against Leuconostoc mesenteroides and Saccharomyces cerevisiae G6PDs than the corresponding monomers. The dibenzyl ether-type dimers had lower IC50 values than the diarylmethane-type dimers against L. mesenteroides G6PD among the bromophenols examined. In contrast, the inhibitory activities of diarylmethane-type dimers against S. cerevisiae G6PD were stronger than those of dibenzyl ether-type dimers. Especially, 3-bromo-2-(2,3-dibromo-4,5-dihydroxybenzyI)-4,5-dihydroxybenzyl methyl ether selectively inhibited S. cerevisiae G6PD compared to L mesenteroides G6PD. (C) 2015 Elsevier B.V. All rights reserved.
Rights: © 2016, Elsevier. Licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International
Type: article (author version)
Appears in Collections:水産科学院・水産科学研究院 (Graduate School of Fisheries Sciences / Faculty of Fisheries Sciences) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 栗原 秀幸

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