|
Hokkaido University Collection of Scholarly and Academic Papers >
Graduate School of Health Sciences / Faculty of Health Sciences >
Peer-reviewed Journal Articles, etc >
Fatal cardiac small-vessel involvement in ANCA-associated vasculitis: an autopsy case report
This item is licensed under:Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International
| Title: | Fatal cardiac small-vessel involvement in ANCA-associated vasculitis: an autopsy case report |
| Authors: | Iwasaki, Sari Browse this author →KAKEN DB | | Suzuki, Akira Browse this author | | Fujisawa, Takashi Browse this author | | Sato, Taiju Browse this author | | Shirai, Shinya Browse this author | | Kamigaki, Mitsunori Browse this author | | Otsuka, Noriyuki Browse this author →KAKEN DB | | Tomaru, Utano Browse this author →KAKEN DB | | Ishizu, Akihiro Browse this author →KAKEN DB |
| Keywords: | ANCA-associated vasculitis | | Cardiac small-vessel involvement | | Sudden death | | Autopsy |
| Issue Date: | Nov-2015 |
| Publisher: | Elsevier |
| Journal Title: | Cardiovascular Pathology |
| Volume: | 24 |
| Issue: | 6 |
| Start Page: | 408 |
| End Page: | 410 |
| Publisher DOI: | 10.1016/j.carpath.2015.07.005 |
| PMID: | 26275759 |
| Abstract: | An 80-year-old Japanese man, who had fever and generalized fatigue not improved by antibiotics, was admitted to our hospital. Laboratory data indicative of renal dysfunction and antineutrophil cytoplasmic antibody (ANCA) in the serum led to the consideration of ANCA-associated vasculitis as a differential diagnosis. However, before the diagnostic confirmation, he was found dead on the bed. Autopsy revealed necrotizing crescentic glomerulonephritis in the kidneys. In addition, necrotizing granulomatous vasculitis with infiltration of multinucleated giant cells and neutrophils but not eosinophils was present in multiple organs. The direct cause of death was presumed as cardiac arrest by lethal arrhythmia because vasculitic lesions were distributed widely in the cardiac walls, acute congestion was observed in the systemic organs, and other causes of death were ruled out. This report presents the unusual manifestation of cardiac small-vessel involvement in ANCA-associated vasculitis related to sudden death. |
| Rights: | ©2015, Elsevier. Licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International http://creativecommons.org/licenses/by-nc-nd/4.0/ | | http://creativecommons.org/licenses/by-nc-nd/4.0/ |
| Type: | article (author version) |
| URI: | http://hdl.handle.net/2115/63950 |
| Appears in Collections: | 保健科学院・保健科学研究院 (Graduate School of Health Sciences / Faculty of Health Sciences) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
|
Submitter: 石津 明洋
|
