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Fatal cardiac small-vessel involvement in ANCA-associated vasculitis: an autopsy case report

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Please use this identifier to cite or link to this item:http://hdl.handle.net/2115/63950

Title: Fatal cardiac small-vessel involvement in ANCA-associated vasculitis: an autopsy case report
Authors: Iwasaki, Sari Browse this author →KAKEN DB
Suzuki, Akira Browse this author
Fujisawa, Takashi Browse this author
Sato, Taiju Browse this author
Shirai, Shinya Browse this author
Kamigaki, Mitsunori Browse this author
Otsuka, Noriyuki Browse this author →KAKEN DB
Tomaru, Utano Browse this author →KAKEN DB
Ishizu, Akihiro Browse this author →KAKEN DB
Keywords: ANCA-associated vasculitis
Cardiac small-vessel involvement
Sudden death
Autopsy
Issue Date: Nov-2015
Publisher: Elsevier
Journal Title: Cardiovascular Pathology
Volume: 24
Issue: 6
Start Page: 408
End Page: 410
Publisher DOI: 10.1016/j.carpath.2015.07.005
PMID: 26275759
Abstract: An 80-year-old Japanese man, who had fever and generalized fatigue not improved by antibiotics, was admitted to our hospital. Laboratory data indicative of renal dysfunction and antineutrophil cytoplasmic antibody (ANCA) in the serum led to the consideration of ANCA-associated vasculitis as a differential diagnosis. However, before the diagnostic confirmation, he was found dead on the bed. Autopsy revealed necrotizing crescentic glomerulonephritis in the kidneys. In addition, necrotizing granulomatous vasculitis with infiltration of multinucleated giant cells and neutrophils but not eosinophils was present in multiple organs. The direct cause of death was presumed as cardiac arrest by lethal arrhythmia because vasculitic lesions were distributed widely in the cardiac walls, acute congestion was observed in the systemic organs, and other causes of death were ruled out. This report presents the unusual manifestation of cardiac small-vessel involvement in ANCA-associated vasculitis related to sudden death.
Rights: ©2015, Elsevier. Licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International http://creativecommons.org/licenses/by-nc-nd/4.0/
http://creativecommons.org/licenses/by-nc-nd/4.0/
Type: article (author version)
URI: http://hdl.handle.net/2115/63950
Appears in Collections:保健科学院・保健科学研究院 (Graduate School of Health Sciences / Faculty of Health Sciences) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 石津 明洋

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