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Differences in morphological features and minimum apparent diffusion coefficient values among breast cancer subtypes using 3-tesla MRI
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| Title: | Differences in morphological features and minimum apparent diffusion coefficient values among breast cancer subtypes using 3-tesla MRI |
| Authors: | Kato, Fumi Browse this author →KAKEN DB | | Kudo, Kohsuke Browse this author →KAKEN DB | | Yamashita, Hiroko Browse this author →KAKEN DB | | Wang, Jeff Browse this author | | Hosoda, Mitsuchika Browse this author →KAKEN DB | | Hatanaka, Kanako C. Browse this author | | Mimura, Rie Browse this author | | Oyama-Manabe, Noriko Browse this author →KAKEN DB | | Shirato, Hiroki Browse this author →KAKEN DB |
| Keywords: | Breast cancer subtypes | | Magnetic resonance imaging | | Diffusion weighed imaging | | Ki-67 |
| Issue Date: | Jan-2016 |
| Publisher: | Elsevier |
| Journal Title: | European journal of radiology |
| Volume: | 85 |
| Issue: | 1 |
| Start Page: | 96 |
| End Page: | 102 |
| Publisher DOI: | 10.1016/j.ejrad.2015.10.018 |
| PMID: | 26724653 |
| Abstract: | Purpose: To compare the morphology and minimum apparent diffusion coefficient (ADC) values among breast cancer subtypes. Methods: Ninety-three patients, who underwent breast MRI and collectively had 98 pathologically proven invasive carcinomas, were enrolled. Morphology was evaluated according to BIRADS-MRI. Minimum ADC was measured. Morphology and minimum ADC were compared among subtypes. Multivariate logistic regression analyses were used to identify the characteristics associated with different subtypes. Results: Oval/round shape was significantly associated with triple-negative (TN) cancer (TN vs. non-TN: 90.9% vs. 45.2%; p = 0.0123). Rim enhancement was significantly less frequent in Luminal A (Luminal A vs. non-Luminal A: 34.2% vs. 76.1%; p = 0.0003). The minimum ADC of Luminal A was significantly higher than that of Luminal B (HER2-negative) (834 vs. 748 x 10^-6 mm2/s; p <0.025). The minimum ADC of the TN-special type was significantly higher than that of TN-ductal (997 vs. 702 x 10^-6 mm2/s; p <0.025). On the multivariate analysis comparing the characteristics associated with Luminal A vs. Luminal B (HER2-negative), the internal enhancement characteristics of the mass and minimum ADC were significant factors. Conclusion: Morphology and minimum ADC would be useful in distinguishing breast cancer subtypes. |
| Rights: | © 2016. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/ | | http://creativecommons.org/licenses/by-nc-nd/4.0/ |
| Type: | article (author version) |
| URI: | http://hdl.handle.net/2115/63971 |
| Appears in Collections: | 北海道大学病院 (Hokkaido University Hospital) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
国際連携研究教育局 : GI-CoRE (Global Institution for Collaborative Research and Education : GI-CoRE) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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Submitter: 加藤 扶美
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