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Differences in morphological features and minimum apparent diffusion coefficient values among breast cancer subtypes using 3-tesla MRI

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Title: Differences in morphological features and minimum apparent diffusion coefficient values among breast cancer subtypes using 3-tesla MRI
Authors: Kato, Fumi Browse this author →KAKEN DB
Kudo, Kohsuke Browse this author →KAKEN DB
Yamashita, Hiroko Browse this author →KAKEN DB
Wang, Jeff Browse this author
Hosoda, Mitsuchika Browse this author →KAKEN DB
Hatanaka, Kanako C. Browse this author
Mimura, Rie Browse this author
Oyama-Manabe, Noriko Browse this author →KAKEN DB
Shirato, Hiroki Browse this author →KAKEN DB
Keywords: Breast cancer subtypes
Magnetic resonance imaging
Diffusion weighed imaging
Ki-67
Issue Date: Jan-2016
Publisher: Elsevier
Journal Title: European journal of radiology
Volume: 85
Issue: 1
Start Page: 96
End Page: 102
Publisher DOI: 10.1016/j.ejrad.2015.10.018
PMID: 26724653
Abstract: Purpose: To compare the morphology and minimum apparent diffusion coefficient (ADC) values among breast cancer subtypes. Methods: Ninety-three patients, who underwent breast MRI and collectively had 98 pathologically proven invasive carcinomas, were enrolled. Morphology was evaluated according to BIRADS-MRI. Minimum ADC was measured. Morphology and minimum ADC were compared among subtypes. Multivariate logistic regression analyses were used to identify the characteristics associated with different subtypes. Results: Oval/round shape was significantly associated with triple-negative (TN) cancer (TN vs. non-TN: 90.9% vs. 45.2%; p = 0.0123). Rim enhancement was significantly less frequent in Luminal A (Luminal A vs. non-Luminal A: 34.2% vs. 76.1%; p = 0.0003). The minimum ADC of Luminal A was significantly higher than that of Luminal B (HER2-negative) (834 vs. 748 x 10^-6 mm2/s; p <0.025). The minimum ADC of the TN-special type was significantly higher than that of TN-ductal (997 vs. 702 x 10^-6 mm2/s; p <0.025). On the multivariate analysis comparing the characteristics associated with Luminal A vs. Luminal B (HER2-negative), the internal enhancement characteristics of the mass and minimum ADC were significant factors. Conclusion: Morphology and minimum ADC would be useful in distinguishing breast cancer subtypes.
Rights: © 2016. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/
http://creativecommons.org/licenses/by-nc-nd/4.0/
Type: article (author version)
URI: http://hdl.handle.net/2115/63971
Appears in Collections:北海道大学病院 (Hokkaido University Hospital) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
国際連携研究教育局 : GI-CoRE (Global Institution for Collaborative Research and Education : GI-CoRE) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 加藤 扶美

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