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Chromatin remodeling complexes in the assembly of long noncoding RNA-dependent nuclear bodies
| Title: | Chromatin remodeling complexes in the assembly of long noncoding RNA-dependent nuclear bodies |
| Authors: | Kawaguchi, Tetsuya Browse this author | | Hirose, Tetsuro Browse this author →KAKEN DB |
| Keywords: | Long noncoding RNA | | nuclear body | | paraspeckle | | nuclear stress body | | omega speckle | | chromatin remodeling complex | | RNA-binding protein | | prion-like domain (PLD) |
| Issue Date: | 2015 |
| Publisher: | Taylor & Francis |
| Journal Title: | Nucleus |
| Volume: | 6 |
| Issue: | 6 |
| Start Page: | 462 |
| End Page: | 467 |
| Publisher DOI: | 10.1080/19491034.2015.1119353 |
| Abstract: | Paraspeckles are subnuclear structures that assemble on nuclear paraspeckle assembly transcript 1 (NEAT1) long noncoding (lnc)RNA. Paraspeckle formation requires appropriate NEAT1 biogenesis and subsequent assembly with multiple prion-like domain (PLD) containing RNA-binding proteins. We found that SWI/SNF chromatin remodeling complexes function as paraspeckle components that interact with paraspeckle proteins (PSPs) and NEAT1. SWI/SNF complexes play an essential role in paraspeckle formation that does not require their ATP-dependent chromatin remodeling activity. Instead, SWI/SNF complexes facilitate organization of the PSP interaction network required for intact paraspeckle assembly. SWI/SNF complexes may collectively bind multiple PSPs to recruit them onto NEAT1. SWI/SNF complexes are also required for Sat III (Satellite III) lncRNA-dependent formation of nuclear stress bodies under heat shock conditions. Organization of the lncRNA-dependent omega speckle in Drosophila also depends on the chromatin remodeling complex. These findings raise the possibility that a common mechanism controls the formation of lncRNA-dependent nuclear body architecture. |
| Rights: | This is an Accepted Manuscript of an article published by Taylor & Francis in Nucleus on 2015, available online: http://www.tandfonline.com/10.1080/19491034.2015.1119353 |
| Type: | article (author version) |
| URI: | http://hdl.handle.net/2115/63974 |
| Appears in Collections: | 遺伝子病制御研究所 (Institute for Genetic Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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Submitter: 廣瀬 哲郎
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