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Chromatin remodeling complexes in the assembly of long noncoding RNA-dependent nuclear bodies

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Title: Chromatin remodeling complexes in the assembly of long noncoding RNA-dependent nuclear bodies
Authors: Kawaguchi, Tetsuya Browse this author
Hirose, Tetsuro Browse this author →KAKEN DB
Keywords: Long noncoding RNA
nuclear body
paraspeckle
nuclear stress body
omega speckle
chromatin remodeling complex
RNA-binding protein
prion-like domain (PLD)
Issue Date: 2015
Publisher: Taylor & Francis
Journal Title: Nucleus
Volume: 6
Issue: 6
Start Page: 462
End Page: 467
Publisher DOI: 10.1080/19491034.2015.1119353
Abstract: Paraspeckles are subnuclear structures that assemble on nuclear paraspeckle assembly transcript 1 (NEAT1) long noncoding (lnc)RNA. Paraspeckle formation requires appropriate NEAT1 biogenesis and subsequent assembly with multiple prion-like domain (PLD) containing RNA-binding proteins. We found that SWI/SNF chromatin remodeling complexes function as paraspeckle components that interact with paraspeckle proteins (PSPs) and NEAT1. SWI/SNF complexes play an essential role in paraspeckle formation that does not require their ATP-dependent chromatin remodeling activity. Instead, SWI/SNF complexes facilitate organization of the PSP interaction network required for intact paraspeckle assembly. SWI/SNF complexes may collectively bind multiple PSPs to recruit them onto NEAT1. SWI/SNF complexes are also required for Sat III (Satellite III) lncRNA-dependent formation of nuclear stress bodies under heat shock conditions. Organization of the lncRNA-dependent omega speckle in Drosophila also depends on the chromatin remodeling complex. These findings raise the possibility that a common mechanism controls the formation of lncRNA-dependent nuclear body architecture.
Rights: This is an Accepted Manuscript of an article published by Taylor & Francis in Nucleus on 2015, available online: http://www.tandfonline.com/10.1080/19491034.2015.1119353
Type: article (author version)
URI: http://hdl.handle.net/2115/63974
Appears in Collections:遺伝子病制御研究所 (Institute for Genetic Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 廣瀬 哲郎

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