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Chromatin remodeling complexes in the assembly of long noncoding RNA-dependent nuclear bodies

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タイトル: Chromatin remodeling complexes in the assembly of long noncoding RNA-dependent nuclear bodies
著者: Kawaguchi, Tetsuya 著作を一覧する
Hirose, Tetsuro 著作を一覧する
キーワード: Long noncoding RNA
nuclear body
paraspeckle
nuclear stress body
omega speckle
chromatin remodeling complex
RNA-binding protein
prion-like domain (PLD)
発行日: 2015年
出版者: Taylor & Francis
誌名: Nucleus
巻: 6
号: 6
開始ページ: 462
終了ページ: 467
出版社 DOI: 10.1080/19491034.2015.1119353
抄録: Paraspeckles are subnuclear structures that assemble on nuclear paraspeckle assembly transcript 1 (NEAT1) long noncoding (lnc)RNA. Paraspeckle formation requires appropriate NEAT1 biogenesis and subsequent assembly with multiple prion-like domain (PLD) containing RNA-binding proteins. We found that SWI/SNF chromatin remodeling complexes function as paraspeckle components that interact with paraspeckle proteins (PSPs) and NEAT1. SWI/SNF complexes play an essential role in paraspeckle formation that does not require their ATP-dependent chromatin remodeling activity. Instead, SWI/SNF complexes facilitate organization of the PSP interaction network required for intact paraspeckle assembly. SWI/SNF complexes may collectively bind multiple PSPs to recruit them onto NEAT1. SWI/SNF complexes are also required for Sat III (Satellite III) lncRNA-dependent formation of nuclear stress bodies under heat shock conditions. Organization of the lncRNA-dependent omega speckle in Drosophila also depends on the chromatin remodeling complex. These findings raise the possibility that a common mechanism controls the formation of lncRNA-dependent nuclear body architecture.
Rights: This is an Accepted Manuscript of an article published by Taylor & Francis in Nucleus on 2015, available online: http://www.tandfonline.com/10.1080/19491034.2015.1119353
資料タイプ: article (author version)
URI: http://hdl.handle.net/2115/63974
出現コレクション:雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

提供者: 廣瀬 哲郎

 

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