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A case of cerebral astroblastoma with rhabdoid features : a cytological, histological, and immunohistochemical study

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Title: A case of cerebral astroblastoma with rhabdoid features : a cytological, histological, and immunohistochemical study
Authors: Yuzawa, Sayaka Browse this author
Nishihara, Hiroshi Browse this author →KAKEN DB
Tanino, Mishie Browse this author →KAKEN DB
Kimura, Taichi Browse this author →KAKEN DB
Moriya, Jun Browse this author
Kamoshima, Yuuta Browse this author
Nagashima, Kazuo Browse this author →KAKEN DB
Tanaka, Shinya Browse this author →KAKEN DB
Keywords: Astroblastoma
Foam cell
Issue Date: Jan-2016
Publisher: Springer Japan
Journal Title: Brain tumor pathology
Volume: 33
Issue: 1
Start Page: 63
End Page: 70
Publisher DOI: 10.1007/s10014-015-0241-5
PMID: 26614252
Abstract: Astroblastoma is a rare neuroepithelial neoplasm of unknown origin, usually occurring in children and young adults. Here we report a case of astroblastoma with uncommon features in an 18-year-old female. The tumor was a well-circumscribed cystic and solid mass with marked gadolinium enhancement in the right frontal lobe. Cytological examination showed polarized monopolar cells with diminished cohesiveness. Tumor cells possessed eccentric round to oval nuclei with abundant eosinophilic cytoplasm, sometimes having cytoplasmic processes. Histopathologically, the tumor showed perivascular pseudorosettes with prominent vascular sclerosis. Foam cells were frequently infiltrated around blood vessels and among tumor cells. In some areas, a solid growth pattern of plump tumor cells with abundant inclusion-like eosinophilic cytoplasm showing rhabdoid appearance was observed. The immunohistochemical study revealed strong and diffuse positivity for vimentin and epithelial membrane antigen. Tumor cells were focally positive for glial fibrillary acidic protein and cytokeratin AE1/AE3. Nuclear immunoreactivity for INI1 protein was evident. The Ki-67 labeling index was 10.8 %. This tumor was finally diagnosed as low-grade astroblastoma and the patient had no evidence of recurrence without postoperative radiotherapy or chemotherapy during the last 6 months of follow-up. This report describes novel cytological, histopathological, and immunohistochemical features of the rare tumor.
Rights: The final publication is available at
Type: article (author version)
Appears in Collections:医学院・医学研究院 (Graduate School of Medicine / Faculty of Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 湯澤 明夏

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