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A case of cerebral astroblastoma with rhabdoid features : a cytological, histological, and immunohistochemical study
| Title: | A case of cerebral astroblastoma with rhabdoid features : a cytological, histological, and immunohistochemical study |
| Authors: | Yuzawa, Sayaka Browse this author | | Nishihara, Hiroshi Browse this author →KAKEN DB | | Tanino, Mishie Browse this author →KAKEN DB | | Kimura, Taichi Browse this author →KAKEN DB | | Moriya, Jun Browse this author | | Kamoshima, Yuuta Browse this author | | Nagashima, Kazuo Browse this author →KAKEN DB | | Tanaka, Shinya Browse this author →KAKEN DB |
| Keywords: | Astroblastoma | | Rhabdoid | | Foam cell | | Cytology |
| Issue Date: | Jan-2016 |
| Publisher: | Springer Japan |
| Journal Title: | Brain tumor pathology |
| Volume: | 33 |
| Issue: | 1 |
| Start Page: | 63 |
| End Page: | 70 |
| Publisher DOI: | 10.1007/s10014-015-0241-5 |
| PMID: | 26614252 |
| Abstract: | Astroblastoma is a rare neuroepithelial neoplasm of unknown origin, usually occurring in children and young adults. Here we report a case of astroblastoma with uncommon features in an 18-year-old female. The tumor was a well-circumscribed cystic and solid mass with marked gadolinium enhancement in the right frontal lobe. Cytological examination showed polarized monopolar cells with diminished cohesiveness. Tumor cells possessed eccentric round to oval nuclei with abundant eosinophilic cytoplasm, sometimes having cytoplasmic processes. Histopathologically, the tumor showed perivascular pseudorosettes with prominent vascular sclerosis. Foam cells were frequently infiltrated around blood vessels and among tumor cells. In some areas, a solid growth pattern of plump tumor cells with abundant inclusion-like eosinophilic cytoplasm showing rhabdoid appearance was observed. The immunohistochemical study revealed strong and diffuse positivity for vimentin and epithelial membrane antigen. Tumor cells were focally positive for glial fibrillary acidic protein and cytokeratin AE1/AE3. Nuclear immunoreactivity for INI1 protein was evident. The Ki-67 labeling index was 10.8 %. This tumor was finally diagnosed as low-grade astroblastoma and the patient had no evidence of recurrence without postoperative radiotherapy or chemotherapy during the last 6 months of follow-up. This report describes novel cytological, histopathological, and immunohistochemical features of the rare tumor. |
| Rights: | The final publication is available at link.springer.com |
| Type: | article (author version) |
| URI: | http://hdl.handle.net/2115/63975 |
| Appears in Collections: | 医学院・医学研究院 (Graduate School of Medicine / Faculty of Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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Submitter: 湯澤 明夏
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