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A case of cerebral astroblastoma with rhabdoid features : a cytological, histological, and immunohistochemical study

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タイトル: A case of cerebral astroblastoma with rhabdoid features : a cytological, histological, and immunohistochemical study
著者: Yuzawa, Sayaka 著作を一覧する
Nishihara, Hiroshi 著作を一覧する
Tanino, Mishie 著作を一覧する
Kimura, Taichi 著作を一覧する
Moriya, Jun 著作を一覧する
Kamoshima, Yuuta 著作を一覧する
Nagashima, Kazuo 著作を一覧する
Tanaka, Shinya 著作を一覧する
キーワード: Astroblastoma
Foam cell
発行日: 2016年 1月
出版者: Springer Japan
誌名: Brain tumor pathology
巻: 33
号: 1
開始ページ: 63
終了ページ: 70
出版社 DOI: 10.1007/s10014-015-0241-5
抄録: Astroblastoma is a rare neuroepithelial neoplasm of unknown origin, usually occurring in children and young adults. Here we report a case of astroblastoma with uncommon features in an 18-year-old female. The tumor was a well-circumscribed cystic and solid mass with marked gadolinium enhancement in the right frontal lobe. Cytological examination showed polarized monopolar cells with diminished cohesiveness. Tumor cells possessed eccentric round to oval nuclei with abundant eosinophilic cytoplasm, sometimes having cytoplasmic processes. Histopathologically, the tumor showed perivascular pseudorosettes with prominent vascular sclerosis. Foam cells were frequently infiltrated around blood vessels and among tumor cells. In some areas, a solid growth pattern of plump tumor cells with abundant inclusion-like eosinophilic cytoplasm showing rhabdoid appearance was observed. The immunohistochemical study revealed strong and diffuse positivity for vimentin and epithelial membrane antigen. Tumor cells were focally positive for glial fibrillary acidic protein and cytokeratin AE1/AE3. Nuclear immunoreactivity for INI1 protein was evident. The Ki-67 labeling index was 10.8 %. This tumor was finally diagnosed as low-grade astroblastoma and the patient had no evidence of recurrence without postoperative radiotherapy or chemotherapy during the last 6 months of follow-up. This report describes novel cytological, histopathological, and immunohistochemical features of the rare tumor.
Rights: The final publication is available at
資料タイプ: article (author version)
出現コレクション:雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

提供者: 湯澤 明夏


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