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Glucose Metabolism and Its Complicated Relationship with Tumor Growth and Perfusion in Head and Neck Squamous Cell Carcinoma

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タイトル: Glucose Metabolism and Its Complicated Relationship with Tumor Growth and Perfusion in Head and Neck Squamous Cell Carcinoma
著者: Fujima, Noriyuki 著作を一覧する
Sakashita, Tomohiro 著作を一覧する
Homma, Akihiro 著作を一覧する
Hirata, Kenji 著作を一覧する
Shiga, Tohru 著作を一覧する
Kudo, Kohsuke 著作を一覧する
Shirato, Hiroki 著作を一覧する
発行日: 2016年11月 8日
出版者: The Public Library of Science
誌名: PLoS ONE
巻: 11
号: 11
開始ページ: e0166236
出版社 DOI: 10.1371/journal.pone.0166236
抄録: Objective: To determine the relationship between tumor glucose metabolism and tumor blood flow (TBF) in head and neck squamous cell carcinoma (HNSCC). Methods: We retrospectively analyzed 57 HNSCC patients. Tumor glucose metabolism was assessed by maximum and mean standardized uptake values (SUVmax and SUVmean) obtained by 18F-fluorodeoxyglucose positron-emission tomography. TBF values were obtained by arterial spin labeling with 3-tesla MRI. The correlations between both SUVs and TBF were assessed in the total series and among patients divided by T-stage (T1-T3 and T4 groups) and tumor location (pharynx/oral cavity and sinonasal cavity groups). Pearson's correlation coefficients were calculated for significant correlations. Results: Significant correlations were detected: a negative correlation in the advanced T-stage group (TBF and SUV max: r, -0.61, SUVmean: r, -0.62), a positive correlation in the non-advanced T-stage pharynx/oral cavity group (TBF and SUVmax: r, 0.70, SUVmean: r, 0.73), a negative correlation in the advanced T-stage pharynx/oral cavity group (TBF and SUVmax: r, -0.62, SUVmean: r, -0.65), and a negative correlation in the advanced Tstage sinonasal cavity group (TBF and SUVmax: r, -0.61, SUVmean: r, -0.65). Conclusion: Significant correlations between glucose uptake and TBF in HNSCC were revealed by the division of T-stage and tumor location.
資料タイプ: article
URI: http://hdl.handle.net/2115/64007
出現コレクション:雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

提供者: 藤間 憲幸

 

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