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Characterization of the glycoproteins of bat-derived influenza viruses

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Title: Characterization of the glycoproteins of bat-derived influenza viruses
Authors: Maruyama, Junki Browse this author
Nao, Naganori Browse this author
Miyamoto, Hiroko Browse this author
Maeda, Ken Browse this author →KAKEN DB
Ogawa, Hirohito Browse this author
Yoshida, Reiko Browse this author
Igarashi, Manabu Browse this author →KAKEN DB
Takada, Ayato Browse this author →KAKEN DB
Keywords: Bat influenza virus
Pseudotyped vesicular stomatitis virus
Issue Date: 15-Jan-2016
Publisher: Elsevier
Journal Title: Virology
Volume: 488
Start Page: 43
End Page: 50
Publisher DOI: 10.1016/j.virol.2015.11.002
PMID: 26605499
Abstract: Recently found bat-derived influenza viruses (BatlVs) have hemagglutinin (HA) and neuraminidase (NA) gene segments distinct from those of previously known influenza A viruses. However, pathogenicities of these BatlVs remain unknown since infectious virus strains have not been isolated yet. To gain insight into the biological properties of BatlVs, we generated vesicular stomatitis viruses (VSVs) pseudotyped with the BatIV HA and NA. We found that VSVs pseudotyped with BatIV HAs and NAs efficiently infected particular bat cell lines but not those derived from primates, and that proteolytic cleavage with a trypsinlike protease was necessary for HA-mediated virus entry. Treatment of the susceptible bat cells with some enzymes and inhibitors revealed that BatIV HAs might recognize some cellular glycoproteins as receptors rather than the sialic acids used for the other known influenza viruses. These data provide fundamental information on the mechanisms underlying the cellular entry and host restriction of BatIVs. (C) 2016 Elsevier Inc. All rights reserved.
Rights: ©2016, Elsevier. Licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International
Type: article (author version)
Appears in Collections:人獣共通感染症リサーチセンター (Research Center for Zoonosis Control) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 高田 礼人

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