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Characterization of the glycoproteins of bat-derived influenza viruses
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| Title: | Characterization of the glycoproteins of bat-derived influenza viruses |
| Authors: | Maruyama, Junki Browse this author | | Nao, Naganori Browse this author | | Miyamoto, Hiroko Browse this author | | Maeda, Ken Browse this author →KAKEN DB | | Ogawa, Hirohito Browse this author | | Yoshida, Reiko Browse this author | | Igarashi, Manabu Browse this author →KAKEN DB | | Takada, Ayato Browse this author →KAKEN DB |
| Keywords: | Bat influenza virus | | hemagglutinin | | Pseudotyped vesicular stomatitis virus |
| Issue Date: | 15-Jan-2016 |
| Publisher: | Elsevier |
| Journal Title: | Virology |
| Volume: | 488 |
| Start Page: | 43 |
| End Page: | 50 |
| Publisher DOI: | 10.1016/j.virol.2015.11.002 |
| PMID: | 26605499 |
| Abstract: | Recently found bat-derived influenza viruses (BatlVs) have hemagglutinin (HA) and neuraminidase (NA) gene segments distinct from those of previously known influenza A viruses. However, pathogenicities of these BatlVs remain unknown since infectious virus strains have not been isolated yet. To gain insight into the biological properties of BatlVs, we generated vesicular stomatitis viruses (VSVs) pseudotyped with the BatIV HA and NA. We found that VSVs pseudotyped with BatIV HAs and NAs efficiently infected particular bat cell lines but not those derived from primates, and that proteolytic cleavage with a trypsinlike protease was necessary for HA-mediated virus entry. Treatment of the susceptible bat cells with some enzymes and inhibitors revealed that BatIV HAs might recognize some cellular glycoproteins as receptors rather than the sialic acids used for the other known influenza viruses. These data provide fundamental information on the mechanisms underlying the cellular entry and host restriction of BatIVs. (C) 2016 Elsevier Inc. All rights reserved. |
| Rights: | ©2016, Elsevier. Licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International http://creativecommons.org/licenses/by-nc-nd/4.0/ | | http://creativecommons.org/licenses/by-nc-nd/4.0/ |
| Type: | article (author version) |
| URI: | http://hdl.handle.net/2115/64129 |
| Appears in Collections: | 人獣共通感染症国際共同研究所 (International Institute for Zoonosis Control) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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Submitter: 高田 礼人
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