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Adhesion of Osteoblast-like Cells (Saos-2) on Micro-/Submicro-Patterned Apatite Scaffolds Fabricated with Apatite Cement Paste by Micro-Molding

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タイトル: Adhesion of Osteoblast-like Cells (Saos-2) on Micro-/Submicro-Patterned Apatite Scaffolds Fabricated with Apatite Cement Paste by Micro-Molding
著者: Akasaka, Tsukasa 著作を一覧する
Miyaji, Hirofumi 著作を一覧する
Kaga, Naoyuki 著作を一覧する
Yokoyama, Atsuro 著作を一覧する
Abe, Shigeaki 著作を一覧する
Yoshida, Yasuhiro 著作を一覧する
キーワード: patterned apatite
micro-molding
micro/submicro
Saos-2
cell adhesion
発行日: 2016年12月
出版者: ナノバイオメディカル学会
Nano Biomedical Society
誌名: Nano Biomedicine
巻: 8
号: 2
開始ページ: 112
終了ページ: 122
抄録: In the present study, we developed patterned apatites with grooves, pillars, and holes by micro-molding. The effects of the patterns on adhesion of the human osteoblastic cell line Saos-2 were investigated. The patterned apatites were fabricated with apatite cement paste using the mi-cro-molding method. The number of attached cells and ratio of cell spreading were estimated by a cell adhesion assay using Saos-2. The resulting patterns of grooves, holes, and pillars at the mi-cro-/submicro-level were easily transferred using the corresponding mold. Saos-2 cells were well orientated on the grooves and filopodia were radially elongated on pillars. The number of attached cells on the patterned apatite was higher than that on the planar apatite. Interestingly, the tendency of increasing of ratios of spreading cells was similar to that of decreasing of water contact angle on apatite pillars. These results show that the adhesion of Saos-2 cells was affected by the type and size of the apatite patterns.
資料タイプ: article
URI: http://hdl.handle.net/2115/64538
出現コレクション:雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

提供者: 赤坂 司

 

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