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Highly Immunogenic DQB1 Mismatch Eplets Are Associated With Development of Chronic Active Antibody-Mediated Rejection : A First Report From Japan

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タイトル: Highly Immunogenic DQB1 Mismatch Eplets Are Associated With Development of Chronic Active Antibody-Mediated Rejection : A First Report From Japan
著者: Iwami, D. 著作を一覧する
Hotta, K. 著作を一覧する
Sasaki, H. 著作を一覧する
Hirose, T. 著作を一覧する
Higuchi, H. 著作を一覧する
Takada, Y. 著作を一覧する
Shinohara, N. 著作を一覧する
発行日: 2017年 1月
出版者: Elsevier
誌名: Transplantation proceedings
巻: 49
号: 1
開始ページ: 84
終了ページ: 87
出版社 DOI: 10.1016/j.transproceed.2016.10.022
抄録: Background: De novo donor-specific antibody (dnDSA), especially against class II HLA, correlates with chronic active antibody-mediated rejection (CAAMR), which eventually leads to graft loss. It would be helpful if we could identify the patients at high risk of dnDSA development in terms of histocompatibility. Structure-based matching strategy assessing mismatched epitopes/eplets by comparing polymorphic amino acid sequences can predict the risk of development of dnDSA and CAAMR. However, it has not been evaluated in Japanese patients whose diversity in HLA is limited. Patients and Methods: We retrospectively studied 55 living related kidney transplant patients and ascertained donor and recipient HLA-A, -B, -DRB1, and -DQB1. The number of mismatched eplets was determined using an algorithm, HLAMatchmaker version 3. The relationship between characteristics of mismatched eplets and development of CAAMR was evaluated. Results: There were 8 patients in the CAAMR group and 47 in the control group. The numbers of mismatched HLAs (3.6 ± 1.2 in CAAMR and 3.7 ± 2.0 in control groups), mismatched eplets (32.2 ± 10.4 in CAAMR and 34.4 ± 19.8 in control groups), mismatched DRB1 eplets (11.2 ± 4.3 in CAAMR and 11.5 ± 7.9 in control groups), and mismatched DQB1 eplets (9.2 ± 4.3 in CAAMR and 10.5 ± 7.3 in control groups) were not significantly different. Significantly more patients had at least one highly immunogenic mismatched eplet (62.5% in CAAMR and 25.5% in control groups; P = .024 by χ2 test). Conclusions: The presence of highly immunogenic mismatched eplets is associated with development of CAAMR.
資料タイプ: article
URI: http://hdl.handle.net/2115/64544
出現コレクション:雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

提供者: 岩見 大基

 

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