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Treg engage lymphotoxin beta receptor for afferent lymphatic transendothelial migration


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タイトル: Treg engage lymphotoxin beta receptor for afferent lymphatic transendothelial migration
著者: Brinkman, C. Colin 著作を一覧する
Iwami, Daiki 著作を一覧する
Hritzo, Molly K. 著作を一覧する
Xiong, Yanbao 著作を一覧する
Ahmad, Sarwat 著作を一覧する
Simon, Thomas 著作を一覧する
Hippen, Keli L. 著作を一覧する
Blazar, Bruce R. 著作を一覧する
Bromberg, Jonathan S. 著作を一覧する
発行日: 2016年 6月21日
出版者: Nature Publishing Group
誌名: Nature communications
巻: 7
開始ページ: 12021
出版社 DOI: 10.1038/ncomms12021
抄録: Regulatory T cells (Tregs) are essential to suppress unwanted immunity or inflammation. After islet allo-transplant Tregs must migrate from blood to allograft, then via afferent lymphatics to draining LN to protect allografts. Here we show that Tregs but not non-Treg T cells use lymphotoxin (LT) during migration from allograft to draining LN, and that LT deficiency or blockade prevents normal migration and allograft protection. Treg LTαβ rapidly modulates cytoskeletal and membrane structure of lymphatic endothelial cells; dependent on VCAM-1 and non-canonical NFκB signalling via LTβR. These results demonstrate a form of T-cell migration used only by Treg in tissues that serves an important role in their suppressive function and is a unique therapeutic focus for modulating suppression.
資料タイプ: article
出現コレクション:雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

提供者: 岩見 大基


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