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Hokkaido University Collection of Scholarly and Academic Papers >
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Treg engage lymphotoxin beta receptor for afferent lymphatic transendothelial migration
This item is licensed under:Creative Commons Attribution 4.0 International
| Title: | Treg engage lymphotoxin beta receptor for afferent lymphatic transendothelial migration |
| Authors: | Brinkman, C. Colin Browse this author | | Iwami, Daiki Browse this author →KAKEN DB | | Hritzo, Molly K. Browse this author | | Xiong, Yanbao Browse this author | | Ahmad, Sarwat Browse this author | | Simon, Thomas Browse this author | | Hippen, Keli L. Browse this author | | Blazar, Bruce R. Browse this author | | Bromberg, Jonathan S. Browse this author |
| Issue Date: | 21-Jun-2016 |
| Publisher: | Nature Publishing Group |
| Journal Title: | Nature communications |
| Volume: | 7 |
| Start Page: | 12021 |
| Publisher DOI: | 10.1038/ncomms12021 |
| Abstract: | Regulatory T cells (Tregs) are essential to suppress unwanted immunity or inflammation. After islet allo-transplant Tregs must migrate from blood to allograft, then via afferent lymphatics to draining LN to protect allografts. Here we show that Tregs but not non-Treg T cells use lymphotoxin (LT) during migration from allograft to draining LN, and that LT deficiency or blockade prevents normal migration and allograft protection. Treg LTαβ rapidly modulates cytoskeletal and membrane structure of lymphatic endothelial cells; dependent on VCAM-1 and non-canonical NFκB signalling via LTβR. These results demonstrate a form of T-cell migration used only by Treg in tissues that serves an important role in their suppressive function and is a unique therapeutic focus for modulating suppression. |
| Rights: | https://creativecommons.org/licenses/by/4.0/ |
| Type: | article |
| URI: | http://hdl.handle.net/2115/64546 |
| Appears in Collections: | 医学院・医学研究院 (Graduate School of Medicine / Faculty of Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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Submitter: 岩見 大基
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