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Treg engage lymphotoxin beta receptor for afferent lymphatic transendothelial migration

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Title: Treg engage lymphotoxin beta receptor for afferent lymphatic transendothelial migration
Authors: Brinkman, C. Colin Browse this author
Iwami, Daiki Browse this author →KAKEN DB
Hritzo, Molly K. Browse this author
Xiong, Yanbao Browse this author
Ahmad, Sarwat Browse this author
Simon, Thomas Browse this author
Hippen, Keli L. Browse this author
Blazar, Bruce R. Browse this author
Bromberg, Jonathan S. Browse this author
Issue Date: 21-Jun-2016
Publisher: Nature Publishing Group
Journal Title: Nature communications
Volume: 7
Start Page: 12021
Publisher DOI: 10.1038/ncomms12021
Abstract: Regulatory T cells (Tregs) are essential to suppress unwanted immunity or inflammation. After islet allo-transplant Tregs must migrate from blood to allograft, then via afferent lymphatics to draining LN to protect allografts. Here we show that Tregs but not non-Treg T cells use lymphotoxin (LT) during migration from allograft to draining LN, and that LT deficiency or blockade prevents normal migration and allograft protection. Treg LTαβ rapidly modulates cytoskeletal and membrane structure of lymphatic endothelial cells; dependent on VCAM-1 and non-canonical NFκB signalling via LTβR. These results demonstrate a form of T-cell migration used only by Treg in tissues that serves an important role in their suppressive function and is a unique therapeutic focus for modulating suppression.
Type: article
Appears in Collections:医学院・医学研究院 (Graduate School of Medicine / Faculty of Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 岩見 大基

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