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Hokkaido University Collection of Scholarly and Academic Papers >
Graduate School of Medicine / Faculty of Medicine >
Peer-reviewed Journal Articles, etc >
The broad distribution of GP2 in mucous glands and secretory products
| Title: | The broad distribution of GP2 in mucous glands and secretory products |
| Authors: | Kimura, Shunsuke Browse this author →KAKEN DB | | Nio-Kobayashi, Junko Browse this author →KAKEN DB | | Kishimoto, Ayuko Browse this author | | Iwanaga, Toshihiko Browse this author →KAKEN DB |
| Issue Date: | 21-Dec-2016 |
| Publisher: | Biomedical Research Press |
| Journal Title: | Biomedical Research |
| Volume: | 37 |
| Issue: | 6 |
| Start Page: | 351 |
| End Page: | 358 |
| Publisher DOI: | 10.2220/biomedres.37.351 |
| Abstract: | GP2, a GPI-anchored glycoprotein that is a useful marker for M cells of Peyer's patches, is functionally related to the uptake of pathogenic bacteria in the gut lumen. Our immunostaining throughout the whole body of mice detected a broader localization than previously found of GP2 in various mucous glands and secretory cells. In the oral cavity, the palatine gland and lingual gland intensely expressed GP2 with immunolabeling along the basolateral membrane of acini and in luminal secretions of ducts. Secretory portions of the duodenal gland as well as the pancreas were immunoreactive for GP2 in the digestive tract. Luminal contents in the small intestine contained aggregations of GP2-immunoreactive substances which mixed with bacteria. The bulbourethral gland of Cowper displayed the GP2 immunoreactivity among the male reproductive organs. The vaginal epithelium contained many GP2-immunoreactive goblet-like cells, the occurrence of which dramatically changed according to the estrous cycle. These findings show that GP2 is a popular secretory product released from mucous glands and secretory cells and may support defense mechanisms against pathogenic bacteria in the tubular organs open to the external milieu. |
| Type: | article |
| URI: | http://hdl.handle.net/2115/64555 |
| Appears in Collections: | 医学院・医学研究院 (Graduate School of Medicine / Faculty of Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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Submitter: 岩永 敏彦
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