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Genotypic characterization of multi-drug-resistant Mycobacterium tuberculosis isolates in Myanmar

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J Infect Chemother v.22p.174-179(2016).pdf318.48 kBPDFView/Open
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Title: Genotypic characterization of multi-drug-resistant Mycobacterium tuberculosis isolates in Myanmar
Authors: Aye, Khin Saw Browse this author
Nakajima, Chie Browse this author →KAKEN DB
Yamaguchi, Tomoyuki Browse this author
Win, Min Min Browse this author
Shwe, Mu Mu Browse this author
Win, Aye Aye Browse this author
Lwin, Thandar Browse this author
Nyunt, Wint Wint Browse this author
Ti, Ti Browse this author
Suzuki, Yasuhiko Browse this author →KAKEN DB
Keywords: Rifampicin
Mycobacterium tuberculosis
Issue Date: Mar-2016
Publisher: Elsevier
Journal Title: Journal of Infection and Chemotherapy
Volume: 22
Issue: 3
Start Page: 174
End Page: 179
Publisher DOI: 10.1016/j.jiac.2015.12.009
PMID: 26806152
Abstract: The number of multi-drug-resistant tuberculosis (MDR-TB) cases is rising worldwide. As a countermeasure against this situation, the implementation of rapid molecular tests to identify MDR-TB would be effective. To develop such tests, information on the frequency and distribution of mutations associating with phenotypic drug resistance in Mycobacterium tuberculosis is required in each country. During 2010, the common mutations in the rpoB, katG and inhA of 178 phenotypically MDR M. tuberculosis isolates collected by the National Tuberculosis Control Program (NTP) in Myanmar were investigated by DNA sequencing. Mutations affecting the 81-bp rifampicin (RIF) resistance-determining region (RRDR) of the rpoB were identified in 127 of 178 isolates (71.3%). Two of the most frequently affected codons were 531 and 526, with percentages of 48.3% and 14.0% respectively. For isoniazid (INH) resistance, 114 of 178 MDR-TB isolates (64.0%) had mutations in the katG in which a mutation-conferring amino acid substitution at codon 315 from Ser to Thr was the most common. Mutations in the inhA regulatory region were also detected in 20 (11.2%) isolates, with the majority at position -15. Distinct mutation rate and pattern from surrounding countries might suggest that MDR-TB has developed and spread domestically in Myanmar. (C) 2016, Japanese Society of Chemotherapy and The Japanese Association for Infectious Diseases. Published by Elsevier Ltd. All rights reserved.
Rights: © 2016. This manuscript version is made available under the CC-BY-NC-ND 4.0 license
Type: article (author version)
Appears in Collections:人獣共通感染症国際共同研究所 (International Institute for Zoonosis Control) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 鈴木 定彦

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