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Allogeneic hematopoietic stem cell transplantation following reduced-intensity conditioning for mycosis fungoides and Sezary syndrome

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Title: Allogeneic hematopoietic stem cell transplantation following reduced-intensity conditioning for mycosis fungoides and Sezary syndrome
Other Titles: RIC-HSCT for MF/SS
Authors: Shiratori, Souichi Browse this author →KAKEN DB
Fujimoto, Katsuya Browse this author
Nishimura, Machiko Browse this author
Hatanaka, Kanako C. Browse this author
Kosugi-Kanaya, Mizuha Browse this author
Okada, Kohei Browse this author
Sugita, Junichi Browse this author
Shigematsu, Akio Browse this author
Hashimoto, Daigo Browse this author
Endo, Tomoyuki Browse this author
Kondo, Takeshi Browse this author →KAKEN DB
Abe, Riichiro Browse this author →KAKEN DB
Hashino, Satoshi Browse this author →KAKEN DB
Matsuno, Yoshihiro Browse this author →KAKEN DB
Shimizu, Hiroshi Browse this author →KAKEN DB
Teshima, Takanori Browse this author →KAKEN DB
Keywords: mycosis fungoides
Sezary syndrome
allogeneic hematopoietic stem cell transplantation
reduced-intensity conditioning
graft-versus-lymphoma effect
Issue Date: Mar-2016
Publisher: Wiley
Journal Title: Hematological oncology
Volume: 34
Issue: 1
Start Page: 9
End Page: 16
Publisher DOI: 10.1002/hon.2162
PMID: 25312300
Abstract: Advanced-stage mycosis fungoides and Sezary syndrome (MF/SS) have a poor prognosis. Allogeneic hematopoietic stem cell transplantation (HSCT), particularly using a reduced-intensity conditioning (RIC) regimen, is a promising treatment for advanced-stage MF/SS. We performed RIC-HSCT in nine patients with advanced MF/SS. With a median follow-up period of 954days after HSCT, the estimated 3-year overall survival was 85.7% (95% confidence interval, 33.4-97.9%) with no non-relapse mortality. Five patients relapsed after RIC-HSCT; however, in four patients whose relapse was detected only from the skin, persistent complete response was achieved in one patient, and the disease was manageable in other three patients by the tapering of immunosuppressants and donor lymphocyte infusion, suggesting that graft-versus-lymphoma effect and "down-staging" effect from advanced stage to early stage by HSCT improve the prognosis of advanced-stage MF/SS. These results suggest that RIC-HSCT is an effective treatment for advanced MF/SS.
Rights: This is the peer reviewed version of the following article: Shiratori, S., Fujimoto, K., Nishimura, M., Hatanaka, K. C., Kosugi-Kanaya, M., Okada, K., Sugita, J., Shigematsu, A., Hashimoto, D., Endo, T., Kondo, T., Abe, R., Hashino, S., Matsuno, Y., Shimizu, H., and Teshima, T. (2016) Allogeneic hematopoietic stem cell transplantation following reduced-intensity conditioning for mycosis fungoides and Sezary syndrome. Hematol Oncol, 34: 9–16, which has been published in final form at http://dx.doi.org/10.1002/hon.2162. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving.
Type: article (author version)
URI: http://hdl.handle.net/2115/64629
Appears in Collections:北海道大学病院 (Hokkaido University Hospital) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 白鳥 聡一

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