|
|
Hokkaido University Collection of Scholarly and Academic Papers >
Hokkaido University Hospital >
Peer-reviewed Journal Articles, etc >
Allogeneic hematopoietic stem cell transplantation following reduced-intensity conditioning for mycosis fungoides and Sezary syndrome
| Title: | Allogeneic hematopoietic stem cell transplantation following reduced-intensity conditioning for mycosis fungoides and Sezary syndrome |
| Other Titles: | RIC-HSCT for MF/SS |
| Authors: | Shiratori, Souichi Browse this author →KAKEN DB | | Fujimoto, Katsuya Browse this author | | Nishimura, Machiko Browse this author | | Hatanaka, Kanako C. Browse this author | | Kosugi-Kanaya, Mizuha Browse this author | | Okada, Kohei Browse this author | | Sugita, Junichi Browse this author | | Shigematsu, Akio Browse this author | | Hashimoto, Daigo Browse this author | | Endo, Tomoyuki Browse this author | | Kondo, Takeshi Browse this author →KAKEN DB | | Abe, Riichiro Browse this author →KAKEN DB | | Hashino, Satoshi Browse this author →KAKEN DB | | Matsuno, Yoshihiro Browse this author →KAKEN DB | | Shimizu, Hiroshi Browse this author →KAKEN DB | | Teshima, Takanori Browse this author →KAKEN DB |
| Keywords: | mycosis fungoides | | Sezary syndrome | | allogeneic hematopoietic stem cell transplantation | | reduced-intensity conditioning | | graft-versus-lymphoma effect |
| Issue Date: | Mar-2016 |
| Publisher: | Wiley |
| Journal Title: | Hematological oncology |
| Volume: | 34 |
| Issue: | 1 |
| Start Page: | 9 |
| End Page: | 16 |
| Publisher DOI: | 10.1002/hon.2162 |
| PMID: | 25312300 |
| Abstract: | Advanced-stage mycosis fungoides and Sezary syndrome (MF/SS) have a poor prognosis. Allogeneic hematopoietic stem cell transplantation (HSCT), particularly using a reduced-intensity conditioning (RIC) regimen, is a promising treatment for advanced-stage MF/SS. We performed RIC-HSCT in nine patients with advanced MF/SS. With a median follow-up period of 954days after HSCT, the estimated 3-year overall survival was 85.7% (95% confidence interval, 33.4-97.9%) with no non-relapse mortality. Five patients relapsed after RIC-HSCT; however, in four patients whose relapse was detected only from the skin, persistent complete response was achieved in one patient, and the disease was manageable in other three patients by the tapering of immunosuppressants and donor lymphocyte infusion, suggesting that graft-versus-lymphoma effect and "down-staging" effect from advanced stage to early stage by HSCT improve the prognosis of advanced-stage MF/SS. These results suggest that RIC-HSCT is an effective treatment for advanced MF/SS. |
| Rights: | This is the peer reviewed version of the following article: Shiratori, S., Fujimoto, K., Nishimura, M., Hatanaka, K. C., Kosugi-Kanaya, M., Okada, K., Sugita, J., Shigematsu, A., Hashimoto, D., Endo, T., Kondo, T., Abe, R., Hashino, S., Matsuno, Y., Shimizu, H., and Teshima, T. (2016) Allogeneic hematopoietic stem cell transplantation following reduced-intensity conditioning for mycosis fungoides and Sezary syndrome. Hematol Oncol, 34: 9–16, which has been published in final form at http://dx.doi.org/10.1002/hon.2162. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving. |
| Type: | article (author version) |
| URI: | http://hdl.handle.net/2115/64629 |
| Appears in Collections: | 北海道大学病院 (Hokkaido University Hospital) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
|
Submitter: 白鳥 聡一
|
