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Otologic and Rhinologic Manifestations of Eosinophilic Granulomatosis with Polyangiitis

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Title: Otologic and Rhinologic Manifestations of Eosinophilic Granulomatosis with Polyangiitis
Other Titles: Otologic and rhinologic manifestations of EGPA
Authors: Nakamaru, Yuji Browse this author →KAKEN DB
Takagi, Dai Browse this author
Suzuki, Masanobu Browse this author
Homma, Aya Browse this author
Morita, Shinya Browse this author
Homma, Akihiro Browse this author →KAKEN DB
Fukuda, Satoshi Browse this author →KAKEN DB
Keywords: Churg-Strauss syndrome
Eosinophilic granulomatosis with polyangiitis
Issue Date: Mar-2016
Publisher: Karger
Journal Title: Audiology & neuro-otology
Volume: 21
Issue: 1
Start Page: 45
End Page: 53
Publisher DOI: 10.1159/000442040
PMID: 26812614
Abstract: Background: Eosinophilic granulomatosis with polyangiitis (EGPA) is a systemic autoimmune disease that manifests as asthma, recurrent sinusitis and peripheral eosinophilia. In this study, we investigated the clinical features of the ear and nasal manifestations of EGPA in comparison with those of granulomatosis with polyangiitis (GPA). Materials and Methods: Twenty-one patients diagnosed with EGPA were studied. The frequency of otologic manifestations, the degree of hearing loss and the frequency of nasal symptoms were assessed. The onset of ear symptoms, sinusitis and asthma in patients with EGPA were also examined. Results: Eleven patients (52.4%) with EGPA demonstrated otologic symptoms. The EGPA patients commonly presented mild-to-moderate mixed or sensorineural hearing loss. The pattern of hearing loss was mainly flat, and all but 1 patient achieved complete remission from their hearing impairments. Eighteen patients (85.7%) with EGPA demonstrated nasal symptoms. Patients with EGPA showed a significantly higher incidence of nasal polyps than did those with GPA. The median Lund and Mackey scoring system score was 13.7 for patients with EGPA, and ethmoid sinus shadows were more severe than those of the maxillary sinus. Most ear symptoms associated with EGPA were observed after definitive diagnosis, although sinusitis and asthma tended to manifest themselves before diagnosis. There were significant differences between the onset of ear symptoms and those of asthma and sinusitis. Conclusion: As over 80% of patients with EGPA had nasal symptoms and over half had ear symptoms, otolaryngologists should be aware of this disease. Recognition of the characteristic ear and nasal symptoms are thought to be particularly important to obtain an early diagnosis of EGPA.
Rights: This is the peer-reviewed but unedited manuscript version of the following article: Audiol Neurotol 2016;21:45-53 (DOI:10.1159/000442040). The final, published version is available at
Type: article (author version)
Appears in Collections:北海道大学病院 (Hokkaido University Hospital) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 中丸 裕爾

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