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Otologic and Rhinologic Manifestations of Eosinophilic Granulomatosis with Polyangiitis

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タイトル: Otologic and Rhinologic Manifestations of Eosinophilic Granulomatosis with Polyangiitis
その他のタイトル: Otologic and rhinologic manifestations of EGPA
著者: Nakamaru, Yuji 著作を一覧する
Takagi, Dai 著作を一覧する
Suzuki, Masanobu 著作を一覧する
Homma, Aya 著作を一覧する
Morita, Shinya 著作を一覧する
Homma, Akihiro 著作を一覧する
Fukuda, Satoshi 著作を一覧する
キーワード: Churg-Strauss syndrome
Eosinophilic granulomatosis with polyangiitis
発行日: 2016年 3月
出版者: Karger
誌名: Audiology & neuro-otology
巻: 21
号: 1
開始ページ: 45
終了ページ: 53
出版社 DOI: 10.1159/000442040
抄録: Background: Eosinophilic granulomatosis with polyangiitis (EGPA) is a systemic autoimmune disease that manifests as asthma, recurrent sinusitis and peripheral eosinophilia. In this study, we investigated the clinical features of the ear and nasal manifestations of EGPA in comparison with those of granulomatosis with polyangiitis (GPA). Materials and Methods: Twenty-one patients diagnosed with EGPA were studied. The frequency of otologic manifestations, the degree of hearing loss and the frequency of nasal symptoms were assessed. The onset of ear symptoms, sinusitis and asthma in patients with EGPA were also examined. Results: Eleven patients (52.4%) with EGPA demonstrated otologic symptoms. The EGPA patients commonly presented mild-to-moderate mixed or sensorineural hearing loss. The pattern of hearing loss was mainly flat, and all but 1 patient achieved complete remission from their hearing impairments. Eighteen patients (85.7%) with EGPA demonstrated nasal symptoms. Patients with EGPA showed a significantly higher incidence of nasal polyps than did those with GPA. The median Lund and Mackey scoring system score was 13.7 for patients with EGPA, and ethmoid sinus shadows were more severe than those of the maxillary sinus. Most ear symptoms associated with EGPA were observed after definitive diagnosis, although sinusitis and asthma tended to manifest themselves before diagnosis. There were significant differences between the onset of ear symptoms and those of asthma and sinusitis. Conclusion: As over 80% of patients with EGPA had nasal symptoms and over half had ear symptoms, otolaryngologists should be aware of this disease. Recognition of the characteristic ear and nasal symptoms are thought to be particularly important to obtain an early diagnosis of EGPA.
Rights: This is the peer-reviewed but unedited manuscript version of the following article: Audiol Neurotol 2016;21:45-53 (DOI:10.1159/000442040). The final, published version is available at
資料タイプ: article (author version)
出現コレクション:雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

提供者: 中丸 裕爾


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