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Influence of Hot Spring Water on Fatty Acid Composition of Skin Surface Lipids in Hairless Mouse Model of Atopic Dermatitis

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タイトル: Influence of Hot Spring Water on Fatty Acid Composition of Skin Surface Lipids in Hairless Mouse Model of Atopic Dermatitis
著者: Nishimura, Kazuhiko 著作を一覧する
Aoyanagi, Naoki 著作を一覧する
Uchino, Eiji 著作を一覧する
Itabashi, Yutaka 著作を一覧する
キーワード: atopic dermatitis
hot spring water
fatty acid
NCN24 mouse
skin surface lipid
fluorescence detection
発行日: 2016年10月
出版者: Pharmaceutical Society of Japan
誌名: Biological and Pharmaceutical Bulletin
巻: 39
号: 10
開始ページ: 1718
終了ページ: 1722
抄録: When hairless NCN24 mice with atopic dermatitis (AD) were sprayed with a petroleum-containing alkaline salt spring water rich in metaboric acid and sodium bicarbonate, AD symptoms diminished. Reversed-phase HPLC with fluorescence detection (HPLC/FD) and online MS revealed that fatty acid (FA) composition of the skin surface lipids was similar to that in non-AD mice compared with that in AD mice. Strong negative correlations were noted between the levels of total serum immunoglobulin E (IgE) and palmitoleic acid and between the levels of total serum IgE and branched-hexadecanoic acid. Conversely, a strong positive correlation was noted between the levels of total serum IgE and linoleic acid. The present study demonstrates that the petroleum-containing spring water alters the FA composition of skin surface lipids in AD mice, which can be used as an index to evaluate inflammation.
資料タイプ: article
URI: http://hdl.handle.net/2115/64694
出現コレクション:雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

提供者: 板橋 豊

 

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