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Influence of Hot Spring Water on Fatty Acid Composition of Skin Surface Lipids in Hairless Mouse Model of Atopic Dermatitis

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Please use this identifier to cite or link to this item:http://hdl.handle.net/2115/64694

Title: Influence of Hot Spring Water on Fatty Acid Composition of Skin Surface Lipids in Hairless Mouse Model of Atopic Dermatitis
Authors: Nishimura, Kazuhiko Browse this author
Aoyanagi, Naoki Browse this author
Uchino, Eiji Browse this author
Itabashi, Yutaka Browse this author →KAKEN DB
Keywords: atopic dermatitis
hot spring water
fatty acid
NCN24 mouse
skin surface lipid
fluorescence detection
Issue Date: Oct-2016
Publisher: Pharmaceutical Society of Japan
Journal Title: Biological and Pharmaceutical Bulletin
Volume: 39
Issue: 10
Start Page: 1718
End Page: 1722
Abstract: When hairless NCN24 mice with atopic dermatitis (AD) were sprayed with a petroleum-containing alkaline salt spring water rich in metaboric acid and sodium bicarbonate, AD symptoms diminished. Reversed-phase HPLC with fluorescence detection (HPLC/FD) and online MS revealed that fatty acid (FA) composition of the skin surface lipids was similar to that in non-AD mice compared with that in AD mice. Strong negative correlations were noted between the levels of total serum immunoglobulin E (IgE) and palmitoleic acid and between the levels of total serum IgE and branched-hexadecanoic acid. Conversely, a strong positive correlation was noted between the levels of total serum IgE and linoleic acid. The present study demonstrates that the petroleum-containing spring water alters the FA composition of skin surface lipids in AD mice, which can be used as an index to evaluate inflammation.
Type: article
URI: http://hdl.handle.net/2115/64694
Appears in Collections:水産科学院・水産科学研究院 (Graduate School of Fisheries Sciences / Faculty of Fisheries Sciences) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 板橋 豊

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