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Hokkaido University Collection of Scholarly and Academic Papers >
Graduate School of Fisheries Sciences / Faculty of Fisheries Sciences >
Peer-reviewed Journal Articles, etc >
Influence of Hot Spring Water on Fatty Acid Composition of Skin Surface Lipids in Hairless Mouse Model of Atopic Dermatitis
| Title: | Influence of Hot Spring Water on Fatty Acid Composition of Skin Surface Lipids in Hairless Mouse Model of Atopic Dermatitis |
| Authors: | Nishimura, Kazuhiko Browse this author | | Aoyanagi, Naoki Browse this author | | Uchino, Eiji Browse this author | | Itabashi, Yutaka Browse this author →KAKEN DB |
| Keywords: | atopic dermatitis | | hot spring water | | fatty acid | | NCN24 mouse | | skin surface lipid | | fluorescence detection |
| Issue Date: | Oct-2016 |
| Publisher: | Pharmaceutical Society of Japan |
| Journal Title: | Biological and Pharmaceutical Bulletin |
| Volume: | 39 |
| Issue: | 10 |
| Start Page: | 1718 |
| End Page: | 1722 |
| Abstract: | When hairless NCN24 mice with atopic dermatitis (AD) were sprayed with a petroleum-containing alkaline salt spring water rich in metaboric acid and sodium bicarbonate, AD symptoms diminished. Reversed-phase HPLC with fluorescence detection (HPLC/FD) and online MS revealed that fatty acid (FA) composition of the skin surface lipids was similar to that in non-AD mice compared with that in AD mice. Strong negative correlations were noted between the levels of total serum immunoglobulin E (IgE) and palmitoleic acid and between the levels of total serum IgE and branched-hexadecanoic acid. Conversely, a strong positive correlation was noted between the levels of total serum IgE and linoleic acid. The present study demonstrates that the petroleum-containing spring water alters the FA composition of skin surface lipids in AD mice, which can be used as an index to evaluate inflammation. |
| Type: | article |
| URI: | http://hdl.handle.net/2115/64694 |
| Appears in Collections: | 水産科学院・水産科学研究院 (Graduate School of Fisheries Sciences / Faculty of Fisheries Sciences) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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Submitter: 板橋 豊
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