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Monitoring Lead (Pb) Pollution and Identifying Pb Pollution Sources in Japan Using Stable Pb Isotope Analysis with Kidneys of Wild Rats

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Title: Monitoring Lead (Pb) Pollution and Identifying Pb Pollution Sources in Japan Using Stable Pb Isotope Analysis with Kidneys of Wild Rats
Authors: Nakata, Hokuto Browse this author
Nakayama, Shouta M. M. Browse this author →KAKEN DB
Oroszlany, Balazs Browse this author
Ikenaka, Yoshinori Browse this author →KAKEN DB
Mizukawa, Hazuki Browse this author →KAKEN DB
Tanaka, Kazuyuki Browse this author
Harunari, Tsunehito Browse this author
Tanikawa, Tsutomu Browse this author
Darwish, Wageh Sobhy Browse this author
Yohannes, Yared B. Browse this author
Saengtienchai, Aksorn Browse this author
Ishizuka, Mayumi Browse this author →KAKEN DB
Keywords: metal contamination
wild rodent
stable Pb isotope
source identification
developed country
Issue Date: 10-Jan-2017
Publisher: MDPI
Journal Title: International Journal of Environmental Research and Public Health
Volume: 14
Issue: 1
Start Page: 56
Publisher DOI: 10.3390/ijerph14010056
Abstract: Although Japan has been considered to have little lead (Pb) pollution in modern times, the actual pollution situation is unclear. The present study aims to investigate the extent of Pb pollution and to identify the pollution sources in Japan using stable Pb isotope analysis with kidneys of wild rats. Wild brown (Rattus norvegicus, n = 43) and black (R. rattus, n = 98) rats were trapped from various sites in Japan. Mean Pb concentrations in the kidneys of rats from Okinawa (15.58 mg/kg, dry weight), Aichi (10.83), Niigata (10.62), Fukuoka (8.09), Ibaraki (5.06), Kyoto (4.58), Osaka (4.57), Kanagawa (3.42), and Tokyo (3.40) were above the threshold (2.50) for histological kidney changes. Similarly, compared with the previous report, it was regarded that even structural and functional kidney damage as well as neurotoxicity have spread among rats in Japan. Additionally, the possibility of human exposure to a high level of Pb was assumed. In regard to stable Pb isotope analysis, distinctive values of stable Pb isotope ratios (Pb-IRs) were detected in some kidney samples with Pb levels above 5.0 mg/kg. This result indicated that composite factors are involved in Pb pollution. However, the identification of a concrete pollution source has not been accomplished due to limited differences among previously reported values of Pb isotope composition in circulating Pb products. Namely, the current study established the limit of Pb isotope analysis for source identification. Further detailed research about monitoring Pb pollution in Japan and the demonstration of a novel method to identify Pb sources are needed.
Type: article
Appears in Collections:獣医学院・獣医学研究院 (Graduate School of Veterinary Medicine / Faculty of Veterinary Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 石塚 真由美

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