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Hokkaido University Collection of Scholarly and Academic Papers >
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Synthesis of Photoreactive 2-Phenethylamine Derivatives : Synthesis of Adenosine Derivatives Enabling Functional Analysis of Adenosine Receptors by Photoaffinity Labeling
| Title: | Synthesis of Photoreactive 2-Phenethylamine Derivatives : Synthesis of Adenosine Derivatives Enabling Functional Analysis of Adenosine Receptors by Photoaffinity Labeling |
| Authors: | Murai, Yuta Browse this author | | Masuda, Katsuyoshi Browse this author | | Ogasawara, Yui Browse this author | | Wang, Lei Browse this author | | Hashidoko, Yasuyuki Browse this author →KAKEN DB | | Hatanaka, Yasumaru Browse this author | | Iwata, So Browse this author | | Kobayashi, Takuya Browse this author | | Hashimoto, Makoto Browse this author →KAKEN DB |
| Keywords: | Phenylazide | | Benzophenone | | Phenyldiazirine | | Phenethylamine | | Adenosine receptors |
| Issue Date: | Apr-2013 |
| Publisher: | Wiley-VCH |
| Journal Title: | European Journal of Organic Chemistry |
| Volume: | 2013 |
| Issue: | 12 |
| Start Page: | 2428 |
| End Page: | 2433 |
| Publisher DOI: | 10.1002/ejoc.201201657 |
| Abstract: | 2-Phenylethylamine is well known as a substructure of many biologically active compounds, and the synthesis of its photoreactive derivatives to allow the analysis of biological functions is reported. This allowed us to synthesise ligands for adenosine receptors, which have many functional roles in biology and have been extensively studied for their many roles in maintaining homeostasis. Adenosine is one of the most common biochemical compounds, but photoaffinity labeling has not yet been used to study adenosine receptors. Synthetic methods for producing photoreactive adenosine derivatives that can be used with adenosine receptors were established for the photophores phenyl azide and benzophenone. The effect of the introduction of the photoreactive components was determined using an adenosine receptor assay. |
| Rights: | This is the peer reviewed version of the following article: Synthesis of Photoreactive 2-Phenethylamine Derivatives - Synthesis of Adenosine Derivatives Enabling Functional Analysis of Adenosine Receptors by Photoaffinity Labeling,European Journal of Organic Chemistry, 2013(12), 2428-2433, which has been published in final form at 10.1002/ejoc.201201657. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving. |
| Type: | article (author version) |
| URI: | http://hdl.handle.net/2115/64884 |
| Appears in Collections: | 農学院・農学研究院 (Graduate School of Agriculture / Faculty of Agriculture) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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Submitter: 橋本 誠
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