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Synthesis of Photoreactive 2-Phenethylamine Derivatives : Synthesis of Adenosine Derivatives Enabling Functional Analysis of Adenosine Receptors by Photoaffinity Labeling

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Title: Synthesis of Photoreactive 2-Phenethylamine Derivatives : Synthesis of Adenosine Derivatives Enabling Functional Analysis of Adenosine Receptors by Photoaffinity Labeling
Authors: Murai, Yuta Browse this author
Masuda, Katsuyoshi Browse this author
Ogasawara, Yui Browse this author
Wang, Lei Browse this author
Hashidoko, Yasuyuki Browse this author →KAKEN DB
Hatanaka, Yasumaru Browse this author
Iwata, So Browse this author
Kobayashi, Takuya Browse this author
Hashimoto, Makoto Browse this author →KAKEN DB
Keywords: Phenylazide
Benzophenone
Phenyldiazirine
Phenethylamine
Adenosine receptors
Issue Date: Apr-2013
Publisher: Wiley-VCH
Journal Title: European Journal of Organic Chemistry
Volume: 2013
Issue: 12
Start Page: 2428
End Page: 2433
Publisher DOI: 10.1002/ejoc.201201657
Abstract: 2-Phenylethylamine is well known as a substructure of many biologically active compounds, and the synthesis of its photoreactive derivatives to allow the analysis of biological functions is reported. This allowed us to synthesise ligands for adenosine receptors, which have many functional roles in biology and have been extensively studied for their many roles in maintaining homeostasis. Adenosine is one of the most common biochemical compounds, but photoaffinity labeling has not yet been used to study adenosine receptors. Synthetic methods for producing photoreactive adenosine derivatives that can be used with adenosine receptors were established for the photophores phenyl azide and benzophenone. The effect of the introduction of the photoreactive components was determined using an adenosine receptor assay.
Rights: This is the peer reviewed version of the following article: Synthesis of Photoreactive 2-Phenethylamine Derivatives - Synthesis of Adenosine Derivatives Enabling Functional Analysis of Adenosine Receptors by Photoaffinity Labeling,European Journal of Organic Chemistry, 2013(12), 2428-2433, which has been published in final form at 10.1002/ejoc.201201657. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving.
Type: article (author version)
URI: http://hdl.handle.net/2115/64884
Appears in Collections:農学院・農学研究院 (Graduate School of Agriculture / Faculty of Agriculture) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 橋本 誠

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