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Sonographic findings of immunoglobulin G4-related sclerosing sialadenitis

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Title: Sonographic findings of immunoglobulin G4-related sclerosing sialadenitis
Authors: Omotehara, Satomi Browse this author
Nishida, Mutsumi Browse this author →KAKEN DB
Satoh, Megumi Browse this author
Inoue, Mamiko Browse this author
Kudoh, Yusuke Browse this author
Horie, Tatsunori Browse this author
Homma, Akihiro Browse this author →KAKEN DB
Nakamaru, Yuji Browse this author →KAKEN DB
Hatanaka, Kanako C. Browse this author
Shimizu, Chikara Browse this author →KAKEN DB
Keywords: Ultrasonography
Immunoglobulin G4-related sclerosing sialadenitis
Submandibular gland
Doppler signaling
Issue Date: Apr-2016
Publisher: Springer
Journal Title: Journal of medical ultrasonics
Volume: 43
Issue: 2
Start Page: 257
End Page: 262
Publisher DOI: 10.1007/s10396-015-0693-6
PMID: 26707999
Abstract: Purpose: We evaluated the sonographic findings of immunoglobulin G4-related sclerosing sialadenitis (IgG4-SS). Methods: Nineteen patients with IgG4-SS and 12 healthy volunteers (controls) were enrolled. The following sonographic features were evaluated: (1) enlargement of the submandibular gland by measurement of the longitudinal diameter and thickness; (2) the contour texture of the submandibular gland (smooth or rough); (3) the internal echo texture, categorized into three sonographic patterns (homogeneous, multiple hypoechoic nodule, and diffuse hypoechoic); and (4) quantitative color Doppler signaling. Results: The longitudinal diameter and the thickness (mean ± SD) of the submandibular gland were significantly greater in patients than in controls (p = 0.005 and p < 0.001, respectively). Contour roughness was seen in 62.9 and 8.3 % of patients and controls (p < 0.001), respectively. Homogeneous echo textures alone were seen in controls, whereas multiple hypoechoic nodule patterns were seen in 60 % of the patients, and diffuse hypoechoic patterns were seen in 40 %. Color Doppler signaling (mean ± SD) was significantly higher in patients as compared with controls (p < 0.001). Conclusion: Patients could be distinguished from healthy volunteers using four distinctive sonographic findings, suggesting that ultrasonography would be a useful diagnostic tool for IgG4-SS.
Rights: The final publication is available at
Type: article (author version)
Appears in Collections:北海道大学病院 (Hokkaido University Hospital) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 表原 里実

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