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Identification of a highly immunogenic mouse breast cancer sub cell line, 4T1-S

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Title: Identification of a highly immunogenic mouse breast cancer sub cell line, 4T1-S
Authors: Abe, Hirotake Browse this author
Wada, Haruka Browse this author →KAKEN DB
Baghdadi, Muhammad Browse this author
Nakanishi, Sayaka Browse this author
Usui, Yuu Browse this author
Tsuchikawa, Takahiro Browse this author →KAKEN DB
Shichinohe, Toshiaki Browse this author →KAKEN DB
Hirano, Satoshi Browse this author →KAKEN DB
Seino, Ken-ichiro Browse this author →KAKEN DB
Keywords: Breast cancer
Issue Date: Apr-2016
Publisher: Springer
Journal Title: Human cell
Volume: 29
Issue: 2
Start Page: 58
End Page: 66
Publisher DOI: 10.1007/s13577-015-0127-1
PMID: 26857856
Abstract: Cancer vaccines serve as a promising clinical immunotherapeutic strategy that help to trigger an effective and specific antitumor immune response compared to conventional therapies. However, poor immunogenicity of tumor cells remains a major obstacle for clinical application, and developing new methods to modify the immunogenicity of tumor cells may help to improve the clinical outcome of cancer vaccines. 4T1 mouse breast cancer cell line has been known as poorly immunogenic and highly metastatic cell line. Using this model, we identified a sub cell line of 4T1-designated as 4T1-Sapporo (4T1-S)-which shows immunogenic properties when used as a vaccine against the same line. In 4T1-S-vaccinated mice, subcutaneous injection of 4T1-S resulted in an antitumor inflammatory response represented by significant enlargement of draining lymph nodes, accompanied with increased frequencies of activated CD8 T cells and a subpopulation of myeloid cells. Additionally, 4T1-S vaccine was ineffective to induce tumor rejection in nude mice, which importantly indicate that 4T1-S vaccine rely on T cell response to induce tumor rejection. Further analysis to identify mechanisms that control tumor immunogenicity in this model may help to develop new methods for improving the efficacies of clinical cancer vaccines.
Rights: The final publication is available at
Type: article (author version)
Appears in Collections:遺伝子病制御研究所 (Institute for Genetic Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 清野 研一郎

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