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Comparison of Different Symptom Assessment Scales for Multiple System Atrophy

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Title: Comparison of Different Symptom Assessment Scales for Multiple System Atrophy
Authors: Matsushima, Masaaki Browse this author →ORCID
Yabe, Ichiro Browse this author →KAKEN DB
Oba, Koji Browse this author →KAKEN DB
Sakushima, Ken Browse this author
Mito, Yasunori Browse this author
Takei, Asako Browse this author
Houzen, Hideki Browse this author
Tsuzaka, Kazufumi Browse this author
Yoshida, Kazuto Browse this author
Maruo, Yasunori Browse this author
Sasaki, Hidenao Browse this author →KAKEN DB
Keywords: Multiple system atrophy
Standardized response mean
Symptom assessment scale
Short-term change
Sample size
Issue Date: Apr-2016
Publisher: Springer
Journal Title: The Cerebellum
Volume: 15
Issue: 2
Start Page: 190
End Page: 200
Publisher DOI: 10.1007/s12311-015-0686-4
PMID: 26093615
Abstract: To identify the most sensitive scale for use in clinical trials on multiple system atrophy (MSA), a short and sensitive scale is needed for MSA clinical trials. Potential candidates are the Unified MSA Rating Scale (UMSARS), Scale for the Assessment and Rating of Ataxia (SARA), Berg Balance Scale (BBS), MSA Health-Related Quality of Life scale (MSA-QoL), and Scales for Outcomes in Parkinson's Disease-Autonomic questionnaire (SCOPA-AUT). We enrolled patients with MSA from eight hospitals in Hokkaido, Japan. Board-certified neurologists assessed each patient at 6-month intervals and scored them on the UMSARS, SARA, BBS, MSA-QoL, and SCOPA-AUT. Score changes were evaluated using the standardized response mean (SRM). The correlation between disease duration and each score was examined. The first evaluation was conducted on 85 patients (60 patients with MSA cerebellar ataxia dominant subtype [MSA-C] and 25 patients with MSA Parkinsonism-dominant subtype [MSA-P]). Sixty-nine patients were examined after 6 months and 63 patients after 12 months. The UMSARS Part 4 had the largest SRM after 6 months and the SARA after 12 months. SRMs for MSA-P, the shorter duration group, and the early-onset group were larger than were those for MSA-C, the longer duration group, and the late-onset group. SRMs for items regarding skilled hand activities, walking, and standing were relatively large. Our study indicates that the UMSARS (parts 2 and 4), SARA, and BBS are sensitive scales for evaluating MSA progression over 12 months. Items with large SRMs effectively evaluated short-term changes.
Rights: The final publication is available at
Type: article (author version)
Appears in Collections:医学院・医学研究院 (Graduate School of Medicine / Faculty of Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 松島 理明

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