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Genetic diversity and antimicrobial resistance pattern of Salmonella enterica serovar Enteritidis clinical isolates in Thailand

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Title: Genetic diversity and antimicrobial resistance pattern of Salmonella enterica serovar Enteritidis clinical isolates in Thailand
Authors: Utrarachkij, Fuangfa Browse this author
Nakajima, Chie Browse this author →KAKEN DB
Siripanichgon, Kanokrat Browse this author
Changkaew, Kanjana Browse this author
Thongpanich, Yuwanda Browse this author
Pornraungwong, Srirat Browse this author
Suthienkul, Orasa Browse this author
Suzuki, Yasuhiko Browse this author →KAKEN DB
Keywords: Salmonella Enteritidis
MLVA typing
Antimicrobial resistance
Issue Date: Apr-2016
Publisher: Elsevier
Journal Title: Journal of Infection and Chemotherapy
Volume: 22
Issue: 4
Start Page: 209
End Page: 215
Publisher DOI: 10.1016/j.jiac.2015.12.011
PMID: 26860961
Abstract: Objective: To trace the history of antimicrobial resistance in Salmonella enterica serovar Enteritidis (S. Enteritidis, SE) circulating in Thailand, we characterised clinical isolates obtained during 2004-2007. Methods: Antimicrobial resistance profiles, multi-locus variable number tandem repeat analysis (MLVA) types and 3 representative virulence determinants (spvA, sodCI and sopE) were established from SE isolates (n = 192) collected from stool and blood of patients throughout Thailand during the period 2004-2007. Results: Resistance was found in SE against 10 out of 11 antimicrobials studied. The highest resistance ratios were observed for nalidixic acid (83.2%), ciprofloxacin (51.1%) and ampicillin (50.5%), and 25.5% were multidrug resistant. Based on five polymorphic tandem repeat loci analysis, MLVA identified 20 distinct types with three closely related predominant types. A significant increase of AMP resistance from 2004 to 2006 was strongly correlated with that of a MLVA type, 5-5-11-7-3. Conclusion: The usage of antimicrobials in human medicine or farm settings might act as selective pressures and cause the spread of resistant strains. Hence, a strict policy on antimicrobial usage needs to be implemented to achieve the control of resistant SE in Thailand. (C) 2016, Japanese Society of Chemotherapy and The Japanese Association for Infectious Diseases. Published by Elsevier Ltd. All rights reserved.
Rights: © 2016. This manuscript version is made available under the CC-BY-NC-ND 4.0 license
Type: article (author version)
Appears in Collections:人獣共通感染症リサーチセンター (Research Center for Zoonosis Control) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 鈴木 定彦

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