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Genetic diversity and antimicrobial resistance pattern of Salmonella enterica serovar Enteritidis clinical isolates in Thailand

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J Infect Chemother_v.22p.209-215(2016).pdf429.34 kBPDF見る/開く
この文献へのリンクには次のURLを使用してください:http://hdl.handle.net/2115/65117

タイトル: Genetic diversity and antimicrobial resistance pattern of Salmonella enterica serovar Enteritidis clinical isolates in Thailand
著者: Utrarachkij, Fuangfa 著作を一覧する
Nakajima, Chie 著作を一覧する
Siripanichgon, Kanokrat 著作を一覧する
Changkaew, Kanjana 著作を一覧する
Thongpanich, Yuwanda 著作を一覧する
Pornraungwong, Srirat 著作を一覧する
Suthienkul, Orasa 著作を一覧する
Suzuki, Yasuhiko 著作を一覧する
キーワード: Salmonella Enteritidis
MLVA typing
Antimicrobial resistance
発行日: 2016年 4月
出版者: Elsevier
誌名: Journal of Infection and Chemotherapy
巻: 22
号: 4
開始ページ: 209
終了ページ: 215
出版社 DOI: 10.1016/j.jiac.2015.12.011
抄録: Objective: To trace the history of antimicrobial resistance in Salmonella enterica serovar Enteritidis (S. Enteritidis, SE) circulating in Thailand, we characterised clinical isolates obtained during 2004-2007. Methods: Antimicrobial resistance profiles, multi-locus variable number tandem repeat analysis (MLVA) types and 3 representative virulence determinants (spvA, sodCI and sopE) were established from SE isolates (n = 192) collected from stool and blood of patients throughout Thailand during the period 2004-2007. Results: Resistance was found in SE against 10 out of 11 antimicrobials studied. The highest resistance ratios were observed for nalidixic acid (83.2%), ciprofloxacin (51.1%) and ampicillin (50.5%), and 25.5% were multidrug resistant. Based on five polymorphic tandem repeat loci analysis, MLVA identified 20 distinct types with three closely related predominant types. A significant increase of AMP resistance from 2004 to 2006 was strongly correlated with that of a MLVA type, 5-5-11-7-3. Conclusion: The usage of antimicrobials in human medicine or farm settings might act as selective pressures and cause the spread of resistant strains. Hence, a strict policy on antimicrobial usage needs to be implemented to achieve the control of resistant SE in Thailand. (C) 2016, Japanese Society of Chemotherapy and The Japanese Association for Infectious Diseases. Published by Elsevier Ltd. All rights reserved.
Rights: © 2016. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/
資料タイプ: article (author version)
URI: http://hdl.handle.net/2115/65117
出現コレクション:雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

提供者: 鈴木 定彦

 

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