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Nonylphenol diethoxylate inhibits apoptosis induced in PC12 cells

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Title: Nonylphenol diethoxylate inhibits apoptosis induced in PC12 cells
Authors: Liu, Chuang Browse this author
Sun, Yongkun Browse this author
Song, Yutong Browse this author
Saito, Takeshi Browse this author
Kurasaki, Masaaki Browse this author →KAKEN DB
Keywords: Nonylphenol diethoxylate
cytochrome c
PC12 cells
Issue Date: 2016
Publisher: Wiley
Journal Title: Environmental Toxicology
Volume: 31
Issue: 11
Start Page: 1389
End Page: 1398
Publisher DOI: 10.1002/tox.22144
PMID: 25847295
Abstract: Nonylphenol and short-chain nonylphenol ethoxylates such as NP2EO are present in aquatic environment as wastewater contaminants, and their toxic effects on aquatic species have been reported. Apoptosis has been shown to be induced by serum deprivation or copper treatment. To understand the toxicity of nonylphenol diethoxylate, we investigated the effects of NP2EO on apoptosis induced by serum deprivation and copper by using PC12 cell system. Nonylphenol diethoxylate itself showed no toxicity and recovered cell viability from apoptosis. In addition, nonylphenol diethoxylate decreased DNA fragmentation caused by apoptosis in PC12 cells. This phenomenon was confirmed after treating apoptotic PC12 cells with nonylphenol diethoxylate, whereas the cytochrome c release into the cytosol decreased compared to that in apoptotic cells not treated with nonylphenol diethoxylates. Furthermore, Bax contents in apoptotic cells were reduced after exposure to nonylphenol diethoxylate. Thus, nonylphenol diethoxylate has the opposite effect on apoptosis in PC12 cells compared to nonylphenol, which enhances apoptosis induced by serum deprivation. The difference in structure of the two compounds is hypothesized to be responsible for this phenomenon. These results indicated that nonylphenol diethoxylate has capability to affect cell differentiation and development and has potentially harmful effect on organisms because of its unexpected impact on apoptosis.
Rights: This is the peer reviewed version of the following article:, which has been published in final form at 10.1002/tox.22144. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving.
Type: article (author version)
Appears in Collections:環境科学院・地球環境科学研究院 (Graduate School of Environmental Science / Faculty of Environmental Earth Science) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 藏崎 正明

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