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Nonylphenol diethoxylate inhibits apoptosis induced in PC12 cells

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タイトル: Nonylphenol diethoxylate inhibits apoptosis induced in PC12 cells
著者: Liu, Chuang 著作を一覧する
Sun, Yongkun 著作を一覧する
Song, Yutong 著作を一覧する
Saito, Takeshi 著作を一覧する
Kurasaki, Masaaki 著作を一覧する
キーワード: Nonylphenol diethoxylate
cytochrome c
PC12 cells
発行日: 2016年
出版者: Wiley
誌名: Environmental Toxicology
巻: 31
号: 11
開始ページ: 1389
終了ページ: 1398
出版社 DOI: 10.1002/tox.22144
抄録: Nonylphenol and short-chain nonylphenol ethoxylates such as NP2EO are present in aquatic environment as wastewater contaminants, and their toxic effects on aquatic species have been reported. Apoptosis has been shown to be induced by serum deprivation or copper treatment. To understand the toxicity of nonylphenol diethoxylate, we investigated the effects of NP2EO on apoptosis induced by serum deprivation and copper by using PC12 cell system. Nonylphenol diethoxylate itself showed no toxicity and recovered cell viability from apoptosis. In addition, nonylphenol diethoxylate decreased DNA fragmentation caused by apoptosis in PC12 cells. This phenomenon was confirmed after treating apoptotic PC12 cells with nonylphenol diethoxylate, whereas the cytochrome c release into the cytosol decreased compared to that in apoptotic cells not treated with nonylphenol diethoxylates. Furthermore, Bax contents in apoptotic cells were reduced after exposure to nonylphenol diethoxylate. Thus, nonylphenol diethoxylate has the opposite effect on apoptosis in PC12 cells compared to nonylphenol, which enhances apoptosis induced by serum deprivation. The difference in structure of the two compounds is hypothesized to be responsible for this phenomenon. These results indicated that nonylphenol diethoxylate has capability to affect cell differentiation and development and has potentially harmful effect on organisms because of its unexpected impact on apoptosis.
Rights: This is the peer reviewed version of the following article:, which has been published in final form at 10.1002/tox.22144. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving.
資料タイプ: article (author version)
出現コレクション:雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

提供者: 藏崎 正明


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