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Role of the Anterior Cingulate Cortex in the Control of Micturition Reflex in a Rat Model of Parkinson's Disease

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Title: Role of the Anterior Cingulate Cortex in the Control of Micturition Reflex in a Rat Model of Parkinson's Disease
Authors: Kitta, Takeya Browse this author →KAKEN DB
Chancellor, Michael B. Browse this author
de Groat, William C. Browse this author
Shinohara, Nobuo Browse this author →KAKEN DB
Yoshimura, Naoki Browse this author
Keywords: urinary bladder, overactive
Parkinson disease
gyrus cinguli
ZM 241385
Parkinson's disease
anterior cingulate cortex
evoked potential
Issue Date: May-2016
Publisher: Elsevier
Journal Title: Journal of urology
Volume: 195
Issue: 5
Start Page: 1613
End Page: 1620
Publisher DOI: 10.1016/j.juro.2015.11.039
PMID: 26626223
Abstract: Purpose: The present study examined dynamic changes in neural activity of the anterior cingulate cortex (ACC) and the midbrain periaqueductal gray (PAG) during the micturition reflex in a Parkinson's disease (PD) model as well as the effects of direct stimulation of the ACC on the micturition reflex. Materials and Methods: Electrodes were inserted into the ACC or the PAG, and the effects of intravenous (i.v.) administration of ZM24138 (ZM: adenosine A2A receptor antagonist) on the pelvic nerve evoked field potentials were examined. The effect of electrical stimulation of the ACC was also examined. Results: PD rats showed bladder overactivity evidenced by a significant decrease in intercontraction intervals (ICI) compared with sham rats. I.v. administration of ZM increased ICI in both groups with the inhibitory effects being greater in PD; and dose-dependently increased the amplitude of evoked potentials in the ACC of PD rats but not in sham rats. I.v. administration of ZM reduced the evoked potential amplitude in the PAG of both groups with the inhibitory effects being greater in PD vs. sham rats. Electrical stimulation of the ACC significantly increased ICI. Conclusions: These results suggest that ACC neurons have an inhibitory role in bladder control because neural activity in the ACC was significantly increased along with suppression of bladder overactivity after ZM administration in the PD model, and the stimulation of the ACC inhibited the micturition reflex. Understanding the roles of the ACC in the modulation of micturition could provide further insights into the pathophysiology of OAB.
Rights: © 2016, Elsevier. Licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International
Type: article (author version)
Appears in Collections:北海道大学病院 (Hokkaido University Hospital) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 橘田 岳也

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