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Release from optimal compressive force suppresses osteoclast differentiation

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Title: Release from optimal compressive force suppresses osteoclast differentiation
Authors: Ikeda, Masaaki Browse this author
Yoshimura, Yoshitaka Browse this author →KAKEN DB
Kikuiri, Takashi Browse this author →KAKEN DB
Matsuno, Mino Browse this author →KAKEN DB
Hasegawa, Tomokazu Browse this author →KAKEN DB
Fukushima, Kumu Browse this author
Hayakawa, Takako Browse this author
Minamikawa, Hajime Browse this author
Suzuki, Kuniaki Browse this author →KAKEN DB
Iida, Junichiro Browse this author →KAKEN DB
Keywords: release from compressive force
compressive force
mechanical stress
Issue Date: Nov-2016
Publisher: Spandidos Publications
Journal Title: Molecular medicine reports
Volume: 14
Issue: 5
Start Page: 4699
End Page: 4705
Publisher DOI: 10.3892/mmr.2016.5801
PMID: 27748817
Abstract: Bone remodeling is an important factor in orthodontic tooth movement. During orthodontic treatment, osteoclasts are subjected to various mechanical stimuli, and this promotes or inhibits osteoclast differentiation and fusion. It has been previously reported that the release from tensile force induces osteoclast differentiation. However, little is known about how release from compressive force affects osteoclasts. The present study investigated the effects of release from compressive force on osteoclasts. The number of tartrate-resistant acid phosphatase (TRAP) -positive multinucleated osteoclasts derived from RAW264.7 cells was counted, and gene expression associated with osteoclast differentiation and fusion in response to release from compressive force was evaluated by reverse transcription-quantitative polymerase chain reaction. Osteoclast number was increased by optimal compressive force application. On release from this force, osteoclast differentiation and fusion were suppressed. mRNA expression of NFATc1 was inhibited for 6 h subsequent to release from compressive force. mRNA expression of the other osteoclast-specific genes, TRAP, RANK, matrix metalloproteinase-9, cathepsin-K, chloride channel 7, ATPase H+ transporting vacuolar proton pump member I, dendritic cell-specific transmembrane protein and osteoclast stimulatory transmembrane protein (OC-STAMP) was significantly inhibited at 3 h following release from compressive force compared with control cells. These findings suggest that release from optimal compressive force suppresses osteoclast differentiation and fusion, which may be important for developing orthodontic treatments.
Type: article
Appears in Collections:歯学院・歯学研究院 (Graduate School of Dental Medicine / Faculty of Dental Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 吉村 善隆

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