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Effects of prenatal perfluoroalkyl acid exposure on cord blood IGF2/H19 methylation and ponderal index : The Hokkaido Study

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Title: Effects of prenatal perfluoroalkyl acid exposure on cord blood IGF2/H19 methylation and ponderal index : The Hokkaido Study
Other Titles: Prenatal PFAAs exposure and IGF2/H19 methylation
Authors: Kobayashi, Sachiko Browse this author
Azumi, Kaoru Browse this author →KAKEN DB
Goudarzi, Houman Browse this author →KAKEN DB
Araki, Atsuko Browse this author →KAKEN DB
Miyashita, Chihiro Browse this author →KAKEN DB
Kobayashi, Sumitaka Browse this author →KAKEN DB
Itoh, Sachiko Browse this author →KAKEN DB
Sasaki, Seiko Browse this author →KAKEN DB
Ishizuka, Mayumi Browse this author →KAKEN DB
Nakazawa, Hiroyuki Browse this author →KAKEN DB
Ikeno, Tamiko Browse this author →KAKEN DB
Kishi, Reiko Browse this author →KAKEN DB
Keywords: epidemiology
perfluorinated chemicals
child exposure/health
endocrine disruptors
DNA methylation
birth cohort
Issue Date: May-2017
Publisher: Nature Publishing Group
Journal Title: Journal of Exposure Science and Environmental Epidemiology
Volume: 27
Issue: 3
Start Page: 251
End Page: 259
Publisher DOI: 10.1038/jes.2016.50
PMID: 27553991
Abstract: Prenatal exposure to perfluoroalkyl acids (PFAAs) influences fetal growth and long-term health. However, whether PFAAs affect offspring DNA methylation patterns to influence health outcomes is yet to be evaluated. Here, we assessed effect of prenatal PFAA exposure on cord blood insulin-like growth factor 2 (IGF2), H19, and long interspersed element 1 (LINE1) methylation and its associations with birth size. Mother-child pairs (N=177) from the Hokkaido Study on Environment and Children's Health were included in the study. Perfluorooctane sulfonate (PFOS) and perfluorooctanoic acid (PFOA) levels in maternal serum were measured by liquid chromatography-tandem mass spectrometry. IGF2, H19, and LINE1 methylation in cord blood DNA was determined by pyrosequencing. After full adjustment in multiple linear regression models, IGF2 methylation showed a significant negative association with log-unit increase in PFOA (partial regression coefficient=-0.73; 95% confidence interval: -1.44 to -0.02). Mediation analysis suggested that reduced IGF2 methylation explained approximately 21% of the observed association between PFOA exposure and reduced ponderal index of the infant at birth. These results indicated that the effects of prenatal PFOA exposure could be mediated through DNA methylation. Further study will be required to determine the potential for long-term adverse health effects of reduced IGF2 methylation induced by PFOA exposure.
Type: article (author version)
Appears in Collections:環境健康科学研究教育センター (Center for Environmental and Health Sciences) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 荒木 敦子

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