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Impaired Myocardial Sympathetic Innervation Is Associated with Diastolic Dysfunction in Heart Failure with Preserved Ejection Fraction : 11C-Hydroxyephedrine PET Study

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Title: Impaired Myocardial Sympathetic Innervation Is Associated with Diastolic Dysfunction in Heart Failure with Preserved Ejection Fraction : 11C-Hydroxyephedrine PET Study
Authors: Aikawa, Tadao Browse this author →KAKEN DB
Naya, Masanao Browse this author →KAKEN DB
Obara, Masahiko Browse this author
Manabe, Osamu Browse this author →KAKEN DB
Tomiyama, Yuuki Browse this author
Magota, Keiichi Browse this author →KAKEN DB
Yamada, Satoshi Browse this author →KAKEN DB
Katoh, Chietsugu Browse this author →KAKEN DB
Tamaki, Nagara Browse this author →KAKEN DB
Tsutsui, Hiroyuki Browse this author →KAKEN DB
Keywords: heart failure with preserved ejection fraction
diastolic dysfunction
11C-hydroxyephedrine
Issue Date: 1-May-2017
Publisher: Society of Nuclear Medicine and Molecular Imaging
Journal Title: The journal of nuclear medicine
Volume: 58
Issue: 5
Start Page: 784
End Page: 790
Publisher DOI: 10.2967/jnumed.116.178558
PMID: 27811122
Abstract: Diastolic dysfunction is important in the pathophysiology of heart failure with preserved ejection fraction (HFpEF). Sympathetic nervous hyperactivity may contribute to the development of diastolic dysfunction. The aim of this study was to determine the relationship between myocardial sympathetic innervation quantified by 11C-hydroxyephedrine PET and diastolic dysfunction in HFpEF patients. Methods: Forty-one HFpEF patients having an echocardiographic left ventricular ejection fraction of 40% or greater and 12 age-matched volunteers without heart failure underwent the echocardiographic examination and 11C-hydroxyephedrine PET. Diastolic dysfunction was classified into grades 0-3 by Doppler echocardiography. Myocardial sympathetic innervation was quantified using the 11C-hydroxyephedrine retention index (RI). The coefficient of variation of 17-segment RIs was derived as a measure of heterogeneity in myocardial 11C-hydroxyephedrine uptake. Results: Grade 2-3 diastolic dysfunction (DD2-3) was found in 19 HFpEF patients (46%). They had a significantly lower global RI (0.075 ± 0.018 min-1) than volunteers (0.123 ± 0.028 min-1, P < 0.001) and HFpEF patients with grade 0-1 diastolic dysfunction (DD0-1) (0.092 ± 0.024 min-1, P = 0.046). HFpEF patients with DD2-3 had the largest coefficient of variation of 17-segment RIs of the 3 groups (18.4% ± 7.7% vs. 14.1% ± 4.7% in HFpEF patients with DD0-1, P = 0.042 for post hoc tests). In multivariate logistic regression analysis, a lower global RI (odds ratio, 0.66 per 0.01 min-1; 95% confidence interval, 0.38-0.99; P = 0.044) was independently associated with the presence of DD2-3 in HFpEF patients. Conclusion: Myocardial sympathetic innervation was impaired in HFpEF patients and was associated with the presence of advanced diastolic dysfunction in HFpEF.
Rights: This research was originally published in JNM. Tadao Aikawa, Masanao Naya, Masahiko Obara, Osamu Manabe, Yuuki Tomiyama, Keiichi Magota, Satoshi Yamada, Chietsugu Katoh, Nagara Tamaki and Hiroyuki Tsutsui. Impaired Myocardial Sympathetic Innervation Is Associated with Diastolic Dysfunction in Heart Failure with Preserved Ejection Fraction : 11C-Hydroxyephedrine PET Study. JNM. 2017;58:784-790. © by the Society of Nuclear Medicine and Molecular Imaging, Inc.
Type: article
URI: http://hdl.handle.net/2115/65239
Appears in Collections:医学院・医学研究院 (Graduate School of Medicine / Faculty of Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 相川 忠夫

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