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ALDH1 and podoplanin expression patterns predict the risk of malignant transformation in oral leukoplakia

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Title: ALDH1 and podoplanin expression patterns predict the risk of malignant transformation in oral leukoplakia
Authors: Habiba, Umma Browse this author
Hida, Kyoko Browse this author →KAKEN DB
Kitamura, Tetsuya Browse this author →KAKEN DB
Yanagawa Matsuda, Aya Browse this author →KAKEN DB
Higashino, Fumihiro Browse this author →KAKEN DB
Ito, Yoichi M. Browse this author →KAKEN DB
Ohiro, Yoichi Browse this author →KAKEN DB
Totsuka, Yasunori Browse this author →KAKEN DB
Shindoh, Masanobu Browse this author →KAKEN DB
Keywords: oral leukoplakia
malignant transformation
cancer stem cell
Issue Date: Jan-2017
Publisher: Spandidos Publications
Journal Title: Oncology Letters
Volume: 13
Issue: 1
Start Page: 321
End Page: 328
Publisher DOI: 10.3892/ol.2016.5379
Abstract: Oral leukoplakia (OL) is a clinically diagnosed preneoplastic lesion of the oral cavity with an increased oral cancer risk. However, the risk of malignant transformation is still difficult to assess. The objective of the present study was to examine the expression patterns of aldehyde dehydrogenase 1 (ALDH1) and podoplanin in OL, and to determine their roles in predicting oral cancer development. In the present study, the expression patterns of ALDH1 and podoplanin were determined in samples from 79 patients with OL. The association between protein expression and clinicopathological parameters, including oral cancer-free survival, was analyzed during a mean follow-up period of 3.4 years. Expression of ALDH1 and podoplanin was observed in 61 and 67% patients, respectively. Kaplan-Meier analysis demonstrated that the expression of the proteins was correlated with the risk of progression to oral cancer. Multivariate analysis revealed that expression of ALDH1 and podoplanin was associated with 3.02- and 2.62-fold increased risk of malignant transformation, respectively. The malignant transformation risk of OL was considerably higher in cases with expression of both proteins. Point-prevalence analysis revealed that 66% of patients with co-expression of ALDH1 and podoplanin developed oral cancer. Taken together, our data indicate that ALDH1 and podoplanin expression patterns in OL are associated with oral cancer development, suggesting that ALDH1 and podoplanin may be useful biomarkers to identify OL patients with a substantially high oral cancer risk.
Type: article
Appears in Collections:遺伝子病制御研究所 (Institute for Genetic Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 樋田 京子

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