|
Hokkaido University Collection of Scholarly and Academic Papers >
Institute for Genetic Medicine >
Peer-reviewed Journal Articles, etc >
ALDH1 and podoplanin expression patterns predict the risk of malignant transformation in oral leukoplakia
This item is licensed under:Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International
| Title: | ALDH1 and podoplanin expression patterns predict the risk of malignant transformation in oral leukoplakia |
| Authors: | Habiba, Umma Browse this author | | Hida, Kyoko Browse this author →KAKEN DB | | Kitamura, Tetsuya Browse this author →KAKEN DB | | Yanagawa Matsuda, Aya Browse this author →KAKEN DB | | Higashino, Fumihiro Browse this author →KAKEN DB | | Ito, Yoichi M. Browse this author →KAKEN DB | | Ohiro, Yoichi Browse this author →KAKEN DB | | Totsuka, Yasunori Browse this author →KAKEN DB | | Shindoh, Masanobu Browse this author →KAKEN DB |
| Keywords: | oral leukoplakia | | malignant transformation | | ALDH1 | | podoplanin | | cancer stem cell |
| Issue Date: | Jan-2017 |
| Publisher: | Spandidos Publications |
| Journal Title: | Oncology Letters |
| Volume: | 13 |
| Issue: | 1 |
| Start Page: | 321 |
| End Page: | 328 |
| Publisher DOI: | 10.3892/ol.2016.5379 |
| Abstract: | Oral leukoplakia (OL) is a clinically diagnosed preneoplastic lesion of the oral cavity with an increased oral cancer risk. However, the risk of malignant transformation is still difficult to assess. The objective of the present study was to examine the expression patterns of aldehyde dehydrogenase 1 (ALDH1) and podoplanin in OL, and to determine their roles in predicting oral cancer development. In the present study, the expression patterns of ALDH1 and podoplanin were determined in samples from 79 patients with OL. The association between protein expression and clinicopathological parameters, including oral cancer-free survival, was analyzed during a mean follow-up period of 3.4 years. Expression of ALDH1 and podoplanin was observed in 61 and 67% patients, respectively. Kaplan-Meier analysis demonstrated that the expression of the proteins was correlated with the risk of progression to oral cancer. Multivariate analysis revealed that expression of ALDH1 and podoplanin was associated with 3.02- and 2.62-fold increased risk of malignant transformation, respectively. The malignant transformation risk of OL was considerably higher in cases with expression of both proteins. Point-prevalence analysis revealed that 66% of patients with co-expression of ALDH1 and podoplanin developed oral cancer. Taken together, our data indicate that ALDH1 and podoplanin expression patterns in OL are associated with oral cancer development, suggesting that ALDH1 and podoplanin may be useful biomarkers to identify OL patients with a substantially high oral cancer risk. |
| Rights: | https://creativecommons.org/licenses/by-nc-nd/4.0/ |
| Type: | article |
| URI: | http://hdl.handle.net/2115/65241 |
| Appears in Collections: | 遺伝子病制御研究所 (Institute for Genetic Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
|
Submitter: 樋田 京子
|
