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Therapeutic efficacy of azithromycin, clarithromycin, minocycline and tosufloxacin against macrolide-resistant and macrolide-sensitive Mycoplasma pneumoniae pneumonia in pediatric patients

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Please use this identifier to cite or link to this item:http://hdl.handle.net/2115/65654

Title: Therapeutic efficacy of azithromycin, clarithromycin, minocycline and tosufloxacin against macrolide-resistant and macrolide-sensitive Mycoplasma pneumoniae pneumonia in pediatric patients
Authors: Ishiguro, Nobuhisa Browse this author →KAKEN DB
Koseki, Naoko Browse this author
Kaiho, Miki Browse this author
Ariga, Tadashi Browse this author →KAKEN DB
Kikuta, Hideaki Browse this author
Togashi, Takehiro Browse this author
Oba, Koji Browse this author →KAKEN DB
Morita, Keisuke Browse this author
Nagano, Naoko Browse this author
Nakanishi, Masanori Browse this author
Hara, Kazuya Browse this author
Hazama, Kyosuke Browse this author
Watanabe, Toru Browse this author
Yamanaka, Tatsuru Browse this author
Sasaki, Satoshi Browse this author
Furuyama, Hideto Browse this author
Shibata, Mutsuo Browse this author
Shida, Satoru Browse this author
Ishizaka, Akihito Browse this author
Tabata, Yuichi Browse this author
Aoyagi, Hayato Browse this author
Naito, Hiroyuki Browse this author
Yoshioka, Mikio Browse this author
Horino, Atsuko Browse this author
Kenri, Tsuyoshi Browse this author
Hokkaido Pediatric Respiratory Infection Study Group Browse this author
Issue Date: 13-Mar-2017
Publisher: The Public Library of Science
Journal Title: PLoS ONE
Volume: 12
Issue: 3
Start Page: e0173635
Publisher DOI: 10.1371/journal.pone.0173635
Abstract: Objective: To clarify therapeutic effects of azithromycin, clarithromycin, minocycline and tosufloxacin against macrolide-resistant Mycoplasma pneumoniae (MRMP) pneumonia and against macrolide-sensitive Mycoplasma pneumoniae (MSMP) pneumonia in pediatric patients. Methods: A prospective, multicenter observational study was conducted from July 2013 to August 2015. The therapeutic effects of azithromycin, clarithromycin, minocycline and tosufloxacin were evaluated in 59 patients with pneumonia caused by MRMP and in 50 patients with pneumonia caused by MSMP. In vitro activities of antimicrobial agents against isolates of Mycoplasma pneumoniae were also measured. Results: Mean durations of fever following commencement of treatment in patients infected with MRMP and MSMP were 5.2 and 1.9 days, respectively (log-rank test, P < 0.0001). Among patients infected with MRMP, mean durations of fever were 4.6, 5.5, 1.0 and 7.5 days for patients treated with azithromycin, clarithromycin, minocycline and tosufloxacin, respectively (log-rank test, P < 0.0001). Among patients infected with MSMP, mean durations of fever were 2.5, 1.7, 0.9 and 4.3 days for patients treated with azithromycin, clarithromycin, minocycline and tosufloxacin, respectively (log-rank test, P = 0.0162). The MIC90s of azithromycin and clarithromycin among the 27 isolates of MRMP were 64 and 256 μg/ml, respectively, and those among the 23 isolates of MSMP were <0.000125 and 0.001 μg/ml, respectively. The MIC90s of minocycline and tosufloxacin among the 27 isolates of MRMP were 1.0 and 0.25 μg/ml, respectively, and those among the 23 isolates of MSMP were 1.0 and 0.5 μg/ml, respectively. Conclusion: Both minocycline and tosufloxacin showed good in vitro activities against MRMP. Minocycline, but not tosufloxacin, shortened the duration of fever in pediatric patients infected with MRMP compared to the duration of fever in patients treated with macrolides.
Rights: https://creativecommons.org/licenses/by/4.0/
Type: article
URI: http://hdl.handle.net/2115/65654
Appears in Collections:北海道大学病院 (Hokkaido University Hospital) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 石黒 信久

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