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Therapeutic efficacy of azithromycin, clarithromycin, minocycline and tosufloxacin against macrolide-resistant and macrolide-sensitive Mycoplasma pneumoniae pneumonia in pediatric patients

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この文献へのリンクには次のURLを使用してください:http://hdl.handle.net/2115/65654

タイトル: Therapeutic efficacy of azithromycin, clarithromycin, minocycline and tosufloxacin against macrolide-resistant and macrolide-sensitive Mycoplasma pneumoniae pneumonia in pediatric patients
著者: Ishiguro, Nobuhisa 著作を一覧する
Koseki, Naoko 著作を一覧する
Kaiho, Miki 著作を一覧する
Ariga, Tadashi 著作を一覧する
Kikuta, Hideaki 著作を一覧する
Togashi, Takehiro 著作を一覧する
Oba, Koji 著作を一覧する
Morita, Keisuke 著作を一覧する
Nagano, Naoko 著作を一覧する
Nakanishi, Masanori 著作を一覧する
Hara, Kazuya 著作を一覧する
Hazama, Kyosuke 著作を一覧する
Watanabe, Toru 著作を一覧する
Yamanaka, Tatsuru 著作を一覧する
Sasaki, Satoshi 著作を一覧する
Furuyama, Hideto 著作を一覧する
Shibata, Mutsuo 著作を一覧する
Shida, Satoru 著作を一覧する
Ishizaka, Akihito 著作を一覧する
Tabata, Yuichi 著作を一覧する
Aoyagi, Hayato 著作を一覧する
Naito, Hiroyuki 著作を一覧する
Yoshioka, Mikio 著作を一覧する
Horino, Atsuko 著作を一覧する
Kenri, Tsuyoshi 著作を一覧する
Hokkaido Pediatric Respiratory Infection Study Group 著作を一覧する
発行日: 2017年 3月13日
出版者: The Public Library of Science
誌名: PLoS ONE
巻: 12
号: 3
開始ページ: e0173635
出版社 DOI: 10.1371/journal.pone.0173635
抄録: Objective: To clarify therapeutic effects of azithromycin, clarithromycin, minocycline and tosufloxacin against macrolide-resistant Mycoplasma pneumoniae (MRMP) pneumonia and against macrolide-sensitive Mycoplasma pneumoniae (MSMP) pneumonia in pediatric patients. Methods: A prospective, multicenter observational study was conducted from July 2013 to August 2015. The therapeutic effects of azithromycin, clarithromycin, minocycline and tosufloxacin were evaluated in 59 patients with pneumonia caused by MRMP and in 50 patients with pneumonia caused by MSMP. In vitro activities of antimicrobial agents against isolates of Mycoplasma pneumoniae were also measured. Results: Mean durations of fever following commencement of treatment in patients infected with MRMP and MSMP were 5.2 and 1.9 days, respectively (log-rank test, P < 0.0001). Among patients infected with MRMP, mean durations of fever were 4.6, 5.5, 1.0 and 7.5 days for patients treated with azithromycin, clarithromycin, minocycline and tosufloxacin, respectively (log-rank test, P < 0.0001). Among patients infected with MSMP, mean durations of fever were 2.5, 1.7, 0.9 and 4.3 days for patients treated with azithromycin, clarithromycin, minocycline and tosufloxacin, respectively (log-rank test, P = 0.0162). The MIC90s of azithromycin and clarithromycin among the 27 isolates of MRMP were 64 and 256 μg/ml, respectively, and those among the 23 isolates of MSMP were <0.000125 and 0.001 μg/ml, respectively. The MIC90s of minocycline and tosufloxacin among the 27 isolates of MRMP were 1.0 and 0.25 μg/ml, respectively, and those among the 23 isolates of MSMP were 1.0 and 0.5 μg/ml, respectively. Conclusion: Both minocycline and tosufloxacin showed good in vitro activities against MRMP. Minocycline, but not tosufloxacin, shortened the duration of fever in pediatric patients infected with MRMP compared to the duration of fever in patients treated with macrolides.
資料タイプ: article
URI: http://hdl.handle.net/2115/65654
出現コレクション:雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

提供者: 石黒 信久

 

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