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Depletion of Gangliosides Enhances Articular Cartilage Repair in Mice

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Title: Depletion of Gangliosides Enhances Articular Cartilage Repair in Mice
Authors: Matsuoka, Masatake Browse this author
Onodera, Tomohiro Browse this author →KAKEN DB
Homan, Kentaro Browse this author
Sasazawa, Fumio Browse this author
Furukawa, Jun-ichi Browse this author
Momma, Daisuke Browse this author
Baba, Rikiya Browse this author
Hontani, Kazutoshi Browse this author
Joutoku, Zenta Browse this author
Matsubara, Shinji Browse this author
Yamashita, Tadashi Browse this author →KAKEN DB
Iwasaki, Norimasa Browse this author →KAKEN DB
Issue Date: 2-Mar-2017
Publisher: Nature Publishing Group
Journal Title: Scientific reports
Volume: 7
Start Page: 43729
Publisher DOI: 10.1038/srep43729
Abstract: Elucidation of the healing mechanisms in damaged tissues is a critical step for establishing breakthroughs in tissue engineering. Articular cartilage is clinically one of the most successful tissues to be repaired with regenerative medicine because of its homogeneous extracellular matrix and few cell types. However, we only poorly understand cartilage repair mechanisms, and hence, regenerated cartilage remains inferior to the native tissues. Here, we show that glycosylation is an important process for hypertrophic differentiation during articular cartilage repair. GM3, which is a precursor molecule for most gangliosides, was transiently expressed in surrounding damaged tissue, and depletion of GM3 synthase enhanced cartilage repair. Gangliosides also regulated chondrocyte hypertrophy via the Indian hedgehog pathway. These results identify a novel mechanism of cartilage healing through chondrocyte hypertrophy that is regulated by glycosylation. Manipulation of gangliosides and their synthases may have beneficial effects on articular cartilage repair.
Type: article
Appears in Collections:北海道大学病院 (Hokkaido University Hospital) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 小野寺 智洋

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