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Depletion of Gangliosides Enhances Articular Cartilage Repair in Mice
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| Title: | Depletion of Gangliosides Enhances Articular Cartilage Repair in Mice |
| Authors: | Matsuoka, Masatake Browse this author | | Onodera, Tomohiro Browse this author →KAKEN DB | | Homan, Kentaro Browse this author | | Sasazawa, Fumio Browse this author | | Furukawa, Jun-ichi Browse this author | | Momma, Daisuke Browse this author | | Baba, Rikiya Browse this author | | Hontani, Kazutoshi Browse this author | | Joutoku, Zenta Browse this author | | Matsubara, Shinji Browse this author | | Yamashita, Tadashi Browse this author →KAKEN DB | | Iwasaki, Norimasa Browse this author →KAKEN DB |
| Issue Date: | 2-Mar-2017 |
| Publisher: | Nature Publishing Group |
| Journal Title: | Scientific reports |
| Volume: | 7 |
| Start Page: | 43729 |
| Publisher DOI: | 10.1038/srep43729 |
| Abstract: | Elucidation of the healing mechanisms in damaged tissues is a critical step for establishing breakthroughs in tissue engineering. Articular cartilage is clinically one of the most successful tissues to be repaired with regenerative medicine because of its homogeneous extracellular matrix and few cell types. However, we only poorly understand cartilage repair mechanisms, and hence, regenerated cartilage remains inferior to the native tissues. Here, we show that glycosylation is an important process for hypertrophic differentiation during articular cartilage repair. GM3, which is a precursor molecule for most gangliosides, was transiently expressed in surrounding damaged tissue, and depletion of GM3 synthase enhanced cartilage repair. Gangliosides also regulated chondrocyte hypertrophy via the Indian hedgehog pathway. These results identify a novel mechanism of cartilage healing through chondrocyte hypertrophy that is regulated by glycosylation. Manipulation of gangliosides and their synthases may have beneficial effects on articular cartilage repair. |
| Rights: | http://creativecommons.org/licenses/by/4.0/ |
| Type: | article |
| URI: | http://hdl.handle.net/2115/65661 |
| Appears in Collections: | 北海道大学病院 (Hokkaido University Hospital) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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Submitter: 小野寺 智洋
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