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Depletion of Gangliosides Enhances Articular Cartilage Repair in Mice


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タイトル: Depletion of Gangliosides Enhances Articular Cartilage Repair in Mice
著者: Matsuoka, Masatake 著作を一覧する
Onodera, Tomohiro 著作を一覧する
Homan, Kentaro 著作を一覧する
Sasazawa, Fumio 著作を一覧する
Furukawa, Jun-ichi 著作を一覧する
Momma, Daisuke 著作を一覧する
Baba, Rikiya 著作を一覧する
Hontani, Kazutoshi 著作を一覧する
Joutoku, Zenta 著作を一覧する
Matsubara, Shinji 著作を一覧する
Yamashita, Tadashi 著作を一覧する
Iwasaki, Norimasa 著作を一覧する
発行日: 2017年 3月 2日
出版者: Nature Publishing Group
誌名: Scientific reports
巻: 7
開始ページ: 43729
出版社 DOI: 10.1038/srep43729
抄録: Elucidation of the healing mechanisms in damaged tissues is a critical step for establishing breakthroughs in tissue engineering. Articular cartilage is clinically one of the most successful tissues to be repaired with regenerative medicine because of its homogeneous extracellular matrix and few cell types. However, we only poorly understand cartilage repair mechanisms, and hence, regenerated cartilage remains inferior to the native tissues. Here, we show that glycosylation is an important process for hypertrophic differentiation during articular cartilage repair. GM3, which is a precursor molecule for most gangliosides, was transiently expressed in surrounding damaged tissue, and depletion of GM3 synthase enhanced cartilage repair. Gangliosides also regulated chondrocyte hypertrophy via the Indian hedgehog pathway. These results identify a novel mechanism of cartilage healing through chondrocyte hypertrophy that is regulated by glycosylation. Manipulation of gangliosides and their synthases may have beneficial effects on articular cartilage repair.
資料タイプ: article
出現コレクション:雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

提供者: 小野寺 智洋


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