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Expression of Notch1 and Numb in small cell lung cancer

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Title: Expression of Notch1 and Numb in small cell lung cancer
Authors: Kikuchi, Hajime Browse this author
Sakakibara-Konishi, Jun Browse this author →KAKEN DB
Furuta, Megumi Browse this author
Yokouchi, Hiroshi Browse this author
Nishihara, Hiroshi Browse this author →KAKEN DB
Yamazaki, Shigeo Browse this author
Uramoto, Hidetaka Browse this author
Tanaka, Fumihiro Browse this author
Harada, Masao Browse this author
Akie, Kenji Browse this author
Sugaya, Fumiko Browse this author
Fujita, Yuka Browse this author
Takamura, Kei Browse this author
Kojima, Tetsuya Browse this author
Harada, Toshiyuki Browse this author
Higuchi, Mitsunori Browse this author
Honjo, Osamu Browse this author
Minami, Yoshinori Browse this author
Watanabe, Naomi Browse this author
Oizumi, Satoshi Browse this author →KAKEN DB
Suzuki, Hiroyuki Browse this author
Ishida, Takashi Browse this author
Dosaka-Akita, Hirotoshi Browse this author →KAKEN DB
Isobe, Hiroshi Browse this author →KAKEN DB
Munakata, Mitsuru Browse this author
Nishimura, Masaharu Browse this author
Keywords: small cell lung cancer
Issue Date: 7-Feb-2017
Publisher: Impact Journals
Journal Title: Oncotarget
Volume: 8
Issue: 6
Start Page: 10348
End Page: 10358
Publisher DOI: 10.18632/oncotarget.14411
Abstract: Notch signaling in tumorigenesis functions as an oncogene or tumor suppressor according to the type of malignancy. Numb represses intracellular Notch signaling. Previous studies have demonstrated that Notch signaling suppresses the proliferation of small cell lung cancer (SCLC) cell lines. However, in SCLC, the association between Notch1 and Numb expression and clinicopathological factors or prognosis has remained unclear. In this study, we evaluated the expression of Notch1 and Numb in SCLC. We immunohistochemically assessed 125 SCLCs that were surgically resected at 16 institutions participating in either the Hokkaido Lung Cancer Clinical Study Group Trial (HOT) or the Fukushima Investigative Group for Healing Thoracic Malignancy (FIGHT) between 2003 and 2013. Correlations between Notch1 or Numb expression and various clinicopathological features were evaluated. Notch1 expression was associated with ECOG performance status. Numb expression was associated with age, sex, and pathological histology (SCLC or Combined SCLC). Analysis of cellular biological expression did not demonstrate a significant correlation between the expression of Notch1 and of Numb. Multivariate Cox regression analysis showed that high Notch1 expression was an independent favorable prognostic factor for SCLC(hazard ratio = 0.503, P = 0.023). High Notch1 expression, but not Numb expression, is associated with favorable prognosis in SCLC.
Type: article
Appears in Collections:北海道大学病院 (Hokkaido University Hospital) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 榊原 純

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