| Title: | Expression of Notch1 and Numb in small cell lung cancer |
| Authors: | Kikuchi, Hajime Browse this author |
| Sakakibara-Konishi, Jun Browse this author →KAKEN DB |
| Furuta, Megumi Browse this author |
| Yokouchi, Hiroshi Browse this author |
| Nishihara, Hiroshi Browse this author →KAKEN DB |
| Yamazaki, Shigeo Browse this author |
| Uramoto, Hidetaka Browse this author |
| Tanaka, Fumihiro Browse this author |
| Harada, Masao Browse this author |
| Akie, Kenji Browse this author |
| Sugaya, Fumiko Browse this author |
| Fujita, Yuka Browse this author |
| Takamura, Kei Browse this author |
| Kojima, Tetsuya Browse this author |
| Harada, Toshiyuki Browse this author |
| Higuchi, Mitsunori Browse this author |
| Honjo, Osamu Browse this author |
| Minami, Yoshinori Browse this author |
| Watanabe, Naomi Browse this author |
| Oizumi, Satoshi Browse this author →KAKEN DB |
| Suzuki, Hiroyuki Browse this author |
| Ishida, Takashi Browse this author |
| Dosaka-Akita, Hirotoshi Browse this author →KAKEN DB |
| Isobe, Hiroshi Browse this author →KAKEN DB |
| Munakata, Mitsuru Browse this author |
| Nishimura, Masaharu Browse this author |
| Keywords: | small cell lung cancer |
| Notch1 |
| Numb |
| immunohistochemistry |
| surgery |
| Issue Date: | 7-Feb-2017 |
| Publisher: | Impact Journals |
| Journal Title: | Oncotarget |
| Volume: | 8 |
| Issue: | 6 |
| Start Page: | 10348 |
| End Page: | 10358 |
| Publisher DOI: | 10.18632/oncotarget.14411 |
| Abstract: | Notch signaling in tumorigenesis functions as an oncogene or tumor suppressor according to the type of malignancy. Numb represses intracellular Notch signaling. Previous studies have demonstrated that Notch signaling suppresses the proliferation of small cell lung cancer (SCLC) cell lines. However, in SCLC, the association between Notch1 and Numb expression and clinicopathological factors or prognosis has remained unclear. In this study, we evaluated the expression of Notch1 and Numb in SCLC. We immunohistochemically assessed 125 SCLCs that were surgically resected at 16 institutions participating in either the Hokkaido Lung Cancer Clinical Study Group Trial (HOT) or the Fukushima Investigative Group for Healing Thoracic Malignancy (FIGHT) between 2003 and 2013. Correlations between Notch1 or Numb expression and various clinicopathological features were evaluated. Notch1 expression was associated with ECOG performance status. Numb expression was associated with age, sex, and pathological histology (SCLC or Combined SCLC). Analysis of cellular biological expression did not demonstrate a significant correlation between the expression of Notch1 and of Numb. Multivariate Cox regression analysis showed that high Notch1 expression was an independent favorable prognostic factor for SCLC(hazard ratio = 0.503, P = 0.023). High Notch1 expression, but not Numb expression, is associated with favorable prognosis in SCLC. |
| Rights: | http://creativecommons.org/licenses/by/3.0/ |
| Type: | article |
| URI: | http://hdl.handle.net/2115/65667 |
| Appears in Collections: | 北海道大学病院 (Hokkaido University Hospital) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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