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The Anti-Oxidant Ergothioneine Augments the Immunomodulatory Function of TLR Agonists by Direct Action on Macrophages

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この文献へのリンクには次のURLを使用してください:http://hdl.handle.net/2115/65671

タイトル: The Anti-Oxidant Ergothioneine Augments the Immunomodulatory Function of TLR Agonists by Direct Action on Macrophages
著者: Yoshida, Sumito 著作を一覧する
Shime, Hiroaki 著作を一覧する
Funami, Kenji 著作を一覧する
Takaki, Hiromi 著作を一覧する
Matsumoto, Misako 著作を一覧する
Kasahara, Masanori 著作を一覧する
Seya, Tsukasa 著作を一覧する
発行日: 2017年 1月23日
出版者: The Public Library of Science
誌名: PLoS ONE
巻: 12
号: 1
開始ページ: e0169360
出版社 DOI: 10.1371/journal.pone.0169360
抄録: L-Ergothioneine (EGT) is a naturally-occurring amino acid which is characterized by its antioxidant property; yet, the physiological role of EGT has yet to be established. We investigated the immune-enhancing properties of EGT, and found that it acts as a potentiator of toll-like receptor (TLR) signaling. When mouse bone marrow-derived macrophages (BMDMs) were pretreated with EGT, TLR signal-mediated cytokine production was augmented in BMDMs. The results were reproducible with TLR2, 3, 4 and 7 agonists. In particular, IL-6 and IL-12p40 were elevated further by pretreatment with EGT in BMDMs, suggesting the induction of M1 polarization. In co-culture assay with OT-II CD4+ T cells and splenic F4/80+ macrophages, EGT significantly induced Th17 skewing in CD4+ T cells. Thus, EGT is an immune modifier as well as a redox controller under TLR stimulation that induces M1 macrophages and a Th17 shift in inflammation.
資料タイプ: article
URI: http://hdl.handle.net/2115/65671
出現コレクション:雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

提供者: 瀬谷 司

 

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