|
Hokkaido University Collection of Scholarly and Academic Papers >
Graduate School of Medicine / Faculty of Medicine >
Peer-reviewed Journal Articles, etc >
The Anti-Oxidant Ergothioneine Augments the Immunomodulatory Function of TLR Agonists by Direct Action on Macrophages
This item is licensed under:Creative Commons Attribution 4.0 International
| Title: | The Anti-Oxidant Ergothioneine Augments the Immunomodulatory Function of TLR Agonists by Direct Action on Macrophages |
| Authors: | Yoshida, Sumito Browse this author | | Shime, Hiroaki Browse this author →KAKEN DB | | Funami, Kenji Browse this author →KAKEN DB | | Takaki, Hiromi Browse this author | | Matsumoto, Misako Browse this author →KAKEN DB | | Kasahara, Masanori Browse this author →KAKEN DB | | Seya, Tsukasa Browse this author →KAKEN DB |
| Issue Date: | 23-Jan-2017 |
| Publisher: | The Public Library of Science |
| Journal Title: | PLoS ONE |
| Volume: | 12 |
| Issue: | 1 |
| Start Page: | e0169360 |
| Publisher DOI: | 10.1371/journal.pone.0169360 |
| Abstract: | L-Ergothioneine (EGT) is a naturally-occurring amino acid which is characterized by its antioxidant property; yet, the physiological role of EGT has yet to be established. We investigated the immune-enhancing properties of EGT, and found that it acts as a potentiator of toll-like receptor (TLR) signaling. When mouse bone marrow-derived macrophages (BMDMs) were pretreated with EGT, TLR signal-mediated cytokine production was augmented in BMDMs. The results were reproducible with TLR2, 3, 4 and 7 agonists. In particular, IL-6 and IL-12p40 were elevated further by pretreatment with EGT in BMDMs, suggesting the induction of M1 polarization. In co-culture assay with OT-II CD4+ T cells and splenic F4/80+ macrophages, EGT significantly induced Th17 skewing in CD4+ T cells. Thus, EGT is an immune modifier as well as a redox controller under TLR stimulation that induces M1 macrophages and a Th17 shift in inflammation. |
| Rights: | http://creativecommons.org/licenses/by/4.0/ |
| Type: | article |
| URI: | http://hdl.handle.net/2115/65671 |
| Appears in Collections: | 医学院・医学研究院 (Graduate School of Medicine / Faculty of Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
|
Submitter: 瀬谷 司
|
