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The Anti-Oxidant Ergothioneine Augments the Immunomodulatory Function of TLR Agonists by Direct Action on Macrophages

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Title: The Anti-Oxidant Ergothioneine Augments the Immunomodulatory Function of TLR Agonists by Direct Action on Macrophages
Authors: Yoshida, Sumito Browse this author
Shime, Hiroaki Browse this author →KAKEN DB
Funami, Kenji Browse this author →KAKEN DB
Takaki, Hiromi Browse this author
Matsumoto, Misako Browse this author →KAKEN DB
Kasahara, Masanori Browse this author →KAKEN DB
Seya, Tsukasa Browse this author →KAKEN DB
Issue Date: 23-Jan-2017
Publisher: The Public Library of Science
Journal Title: PLoS ONE
Volume: 12
Issue: 1
Start Page: e0169360
Publisher DOI: 10.1371/journal.pone.0169360
Abstract: L-Ergothioneine (EGT) is a naturally-occurring amino acid which is characterized by its antioxidant property; yet, the physiological role of EGT has yet to be established. We investigated the immune-enhancing properties of EGT, and found that it acts as a potentiator of toll-like receptor (TLR) signaling. When mouse bone marrow-derived macrophages (BMDMs) were pretreated with EGT, TLR signal-mediated cytokine production was augmented in BMDMs. The results were reproducible with TLR2, 3, 4 and 7 agonists. In particular, IL-6 and IL-12p40 were elevated further by pretreatment with EGT in BMDMs, suggesting the induction of M1 polarization. In co-culture assay with OT-II CD4+ T cells and splenic F4/80+ macrophages, EGT significantly induced Th17 skewing in CD4+ T cells. Thus, EGT is an immune modifier as well as a redox controller under TLR stimulation that induces M1 macrophages and a Th17 shift in inflammation.
Type: article
Appears in Collections:医学院・医学研究院 (Graduate School of Medicine / Faculty of Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 瀬谷 司

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