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Combined effect of astaxanthin and squalene on oxidative stress in vivo

Sangeetha et al (2016)-MCB-MS Revised-2.pdf213.79 kBPDF見る/開く

タイトル: Combined effect of astaxanthin and squalene on oxidative stress in vivo
著者: Kumar, Sangeetha Ravi 著作を一覧する
Narayan, Bhaskar 著作を一覧する
Sawada, Yuki 著作を一覧する
Hosokawa, Masashi 著作を一覧する
Miyashita, Kazuo 著作を一覧する
キーワード: Antioxidant enzymes
KK-A(y) mice
Lipid hydroperoxides
発行日: 2016年 6月
出版者: Springer
誌名: Molecular and cellular biochemistry
巻: 417
号: 1-2
開始ページ: 57
終了ページ: 65
出版社 DOI: 10.1007/s11010-016-2713-2
抄録: Obesity and diabetes, risk factors for metabolic syndrome, are characterized by oxidative stress and inflammatory responses. Marine biofunctionals, astaxanthin (Ax) and squalene (SQ), were evaluated for their combined effect. Groups of male KK-A (y) mice were fed high fat/sucrose diet for 4 weeks, supplemented with either 0.1 %Ax, 2 %SQ or 0.1 %Ax + 2 %SQ. In comparison to control, Sod was elevated in only Ax + SQ. However, Gpx was highest in Ax + SQ, indicating the combined antioxidant effect of Ax and SQ. This was supported by elevated mRNA expression of Sod1 and Gpx1. Except adiponectin (elevated in Ax and Ax + SQ), expression of other inflammatory markers was not altered. Blood glucose levels were decreased in SQ and Ax + SQ while liver triglycerides decreased in SQ group. This is the first in vivo study demonstrating combined effects of Ax and SQ resulting in antioxidant effects and modulation of glucose/triglyceride levels. This study highlights the benefit of utilizing Ax and SQ together for management of obesity/diabetes.
Rights: The final publication is available at
資料タイプ: article (author version)
出現コレクション:雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

提供者: 宮下 和夫


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