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Hokkaido University Collection of Scholarly and Academic Papers >
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Combined effect of astaxanthin and squalene on oxidative stress in vivo
| Title: | Combined effect of astaxanthin and squalene on oxidative stress in vivo |
| Authors: | Kumar, Sangeetha Ravi Browse this author | | Narayan, Bhaskar Browse this author | | Sawada, Yuki Browse this author | | Hosokawa, Masashi Browse this author →KAKEN DB | | Miyashita, Kazuo Browse this author →KAKEN DB |
| Keywords: | Antioxidant enzymes | | Astaxanthin | | KK-A(y) mice | | Lipid hydroperoxides | | Squalene |
| Issue Date: | Jun-2016 |
| Publisher: | Springer |
| Journal Title: | Molecular and cellular biochemistry |
| Volume: | 417 |
| Issue: | 1-2 |
| Start Page: | 57 |
| End Page: | 65 |
| Publisher DOI: | 10.1007/s11010-016-2713-2 |
| PMID: | 27188184 |
| Abstract: | Obesity and diabetes, risk factors for metabolic syndrome, are characterized by oxidative stress and inflammatory responses. Marine biofunctionals, astaxanthin (Ax) and squalene (SQ), were evaluated for their combined effect. Groups of male KK-A (y) mice were fed high fat/sucrose diet for 4 weeks, supplemented with either 0.1 %Ax, 2 %SQ or 0.1 %Ax + 2 %SQ. In comparison to control, Sod was elevated in only Ax + SQ. However, Gpx was highest in Ax + SQ, indicating the combined antioxidant effect of Ax and SQ. This was supported by elevated mRNA expression of Sod1 and Gpx1. Except adiponectin (elevated in Ax and Ax + SQ), expression of other inflammatory markers was not altered. Blood glucose levels were decreased in SQ and Ax + SQ while liver triglycerides decreased in SQ group. This is the first in vivo study demonstrating combined effects of Ax and SQ resulting in antioxidant effects and modulation of glucose/triglyceride levels. This study highlights the benefit of utilizing Ax and SQ together for management of obesity/diabetes. |
| Rights: | The final publication is available at link.springer.com |
| Type: | article (author version) |
| URI: | http://hdl.handle.net/2115/65792 |
| Appears in Collections: | 水産科学院・水産科学研究院 (Graduate School of Fisheries Sciences / Faculty of Fisheries Sciences) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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Submitter: 宮下 和夫
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