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Combined effect of astaxanthin and squalene on oxidative stress in vivo

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Please use this identifier to cite or link to this item:http://hdl.handle.net/2115/65792

Title: Combined effect of astaxanthin and squalene on oxidative stress in vivo
Authors: Kumar, Sangeetha Ravi Browse this author
Narayan, Bhaskar Browse this author
Sawada, Yuki Browse this author
Hosokawa, Masashi Browse this author →KAKEN DB
Miyashita, Kazuo Browse this author →KAKEN DB
Keywords: Antioxidant enzymes
Astaxanthin
KK-A(y) mice
Lipid hydroperoxides
Squalene
Issue Date: Jun-2016
Publisher: Springer
Journal Title: Molecular and cellular biochemistry
Volume: 417
Issue: 1-2
Start Page: 57
End Page: 65
Publisher DOI: 10.1007/s11010-016-2713-2
PMID: 27188184
Abstract: Obesity and diabetes, risk factors for metabolic syndrome, are characterized by oxidative stress and inflammatory responses. Marine biofunctionals, astaxanthin (Ax) and squalene (SQ), were evaluated for their combined effect. Groups of male KK-A (y) mice were fed high fat/sucrose diet for 4 weeks, supplemented with either 0.1 %Ax, 2 %SQ or 0.1 %Ax + 2 %SQ. In comparison to control, Sod was elevated in only Ax + SQ. However, Gpx was highest in Ax + SQ, indicating the combined antioxidant effect of Ax and SQ. This was supported by elevated mRNA expression of Sod1 and Gpx1. Except adiponectin (elevated in Ax and Ax + SQ), expression of other inflammatory markers was not altered. Blood glucose levels were decreased in SQ and Ax + SQ while liver triglycerides decreased in SQ group. This is the first in vivo study demonstrating combined effects of Ax and SQ resulting in antioxidant effects and modulation of glucose/triglyceride levels. This study highlights the benefit of utilizing Ax and SQ together for management of obesity/diabetes.
Rights: The final publication is available at link.springer.com
Type: article (author version)
URI: http://hdl.handle.net/2115/65792
Appears in Collections:水産科学院・水産科学研究院 (Graduate School of Fisheries Sciences / Faculty of Fisheries Sciences) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 宮下 和夫

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