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Hokkaido University Collection of Scholarly and Academic Papers >
Graduate School of Medicine / Faculty of Medicine >
Peer-reviewed Journal Articles, etc >
Characteristics of patients with liver cancer in the BioBank Japan project
This item is licensed under:Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International
| Title: | Characteristics of patients with liver cancer in the BioBank Japan project |
| Authors: | Ukawa, Shigekazu Browse this author →KAKEN DB | | Okada, Emiko Browse this author →KAKEN DB | | Nakamura, Koshi Browse this author →KAKEN DB | | Hirata, Makoto Browse this author | | Nagai, Akiko Browse this author | | Matsuda, Koichi Browse this author →KAKEN DB | | Yamagata, Zentaro Browse this author | | Kamatani, Yoichiro Browse this author | | Ninomiya, Toshiharu Browse this author | | Kiyohara, Yutaka Browse this author | | Muto, Kaori Browse this author | | Kubo, Michiaki Browse this author →KAKEN DB | | Nakamura, Yusuke Browse this author →KAKEN DB | | BioBank Japan Cooperative Hospital Group Browse this author | | Tamakoshi, Akiko Browse this author →KAKEN DB |
| Keywords: | Liver cancer | | Cohort | | Lifestyle | | Tumor biomarkers | | Survival rate |
| Issue Date: | Mar-2017 |
| Publisher: | Elsevier |
| Journal Title: | Journal of epidemiology |
| Volume: | 27 |
| Issue: | 3, Supplement |
| Start Page: | S43 |
| End Page: | S48 |
| Publisher DOI: | 10.1016/j.je.2016.12.007 |
| Abstract: | Background: Liver cancer is the fifth cause of cancer-related deaths in Japan. The BioBank Japan (BBJ) project included 200,000 patients with 47 diseases and samples; their clinical information can be used for further studies. Methods: Patients diagnosed with liver cancer (n = 1733; 1316 men, 417 women) were included. Histology, patient characteristics, clinical characteristics, and causes of death were collected. Cumulative and relative survival rates for liver cancer were calculated. Results: Of the 1354 patients with available liver cancer histology, 91.9% had hepatocellular carcinoma (HCC). Compared with the National Health and Nutrition Examination Survey, greater proportions of the male patients in this cohort were daily alcohol consumers (26%), and a greater proportion of the men was overweight/obesity (22%). Although Japan is the only Asian country with a predominance of hepatitis C virus (HCV)-related HCC, the prevalence of HCV infection (44%) was lower than that in a previous study. The 3-, 5-, and 10-year cumulative survival rates were 57%, 47%, and 25% in men, respectively, and 49%, 41%, and 27% in women, respectively. Conclusions: The present results provide an overview of the patients with liver cancer in the BBJ project. We are planning further analyses combined with various high-throughput ‘omics’ technologies. |
| Rights: | http://creativecommons.org/licenses/by-nc-nd/4.0/ |
| Type: | article |
| URI: | http://hdl.handle.net/2115/65811 |
| Appears in Collections: | 医学院・医学研究院 (Graduate School of Medicine / Faculty of Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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Submitter: 玉腰 暁子
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