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Characteristics of patients with liver cancer in the BioBank Japan project

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Title: Characteristics of patients with liver cancer in the BioBank Japan project
Authors: Ukawa, Shigekazu Browse this author →KAKEN DB
Okada, Emiko Browse this author →KAKEN DB
Nakamura, Koshi Browse this author →KAKEN DB
Hirata, Makoto Browse this author
Nagai, Akiko Browse this author
Matsuda, Koichi Browse this author →KAKEN DB
Yamagata, Zentaro Browse this author
Kamatani, Yoichiro Browse this author
Ninomiya, Toshiharu Browse this author
Kiyohara, Yutaka Browse this author
Muto, Kaori Browse this author
Kubo, Michiaki Browse this author →KAKEN DB
Nakamura, Yusuke Browse this author →KAKEN DB
BioBank Japan Cooperative Hospital Group Browse this author
Tamakoshi, Akiko Browse this author →KAKEN DB
Keywords: Liver cancer
Cohort
Lifestyle
Tumor biomarkers
Survival rate
Issue Date: Mar-2017
Publisher: Elsevier
Journal Title: Journal of epidemiology
Volume: 27
Issue: 3, Supplement
Start Page: S43
End Page: S48
Publisher DOI: 10.1016/j.je.2016.12.007
Abstract: Background: Liver cancer is the fifth cause of cancer-related deaths in Japan. The BioBank Japan (BBJ) project included 200,000 patients with 47 diseases and samples; their clinical information can be used for further studies. Methods: Patients diagnosed with liver cancer (n = 1733; 1316 men, 417 women) were included. Histology, patient characteristics, clinical characteristics, and causes of death were collected. Cumulative and relative survival rates for liver cancer were calculated. Results: Of the 1354 patients with available liver cancer histology, 91.9% had hepatocellular carcinoma (HCC). Compared with the National Health and Nutrition Examination Survey, greater proportions of the male patients in this cohort were daily alcohol consumers (26%), and a greater proportion of the men was overweight/obesity (22%). Although Japan is the only Asian country with a predominance of hepatitis C virus (HCV)-related HCC, the prevalence of HCV infection (44%) was lower than that in a previous study. The 3-, 5-, and 10-year cumulative survival rates were 57%, 47%, and 25% in men, respectively, and 49%, 41%, and 27% in women, respectively. Conclusions: The present results provide an overview of the patients with liver cancer in the BBJ project. We are planning further analyses combined with various high-throughput ‘omics’ technologies.
Rights: http://creativecommons.org/licenses/by-nc-nd/4.0/
Type: article
URI: http://hdl.handle.net/2115/65811
Appears in Collections:医学院・医学研究院 (Graduate School of Medicine / Faculty of Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 玉腰 暁子

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