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Characteristics and prognosis of Japanese female breast cancer patients : The BioBank Japan project


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タイトル: Characteristics and prognosis of Japanese female breast cancer patients : The BioBank Japan project
著者: Nakamura, Koshi 著作を一覧する
Okada, Emiko 著作を一覧する
Ukawa, Shigekazu 著作を一覧する
Hirata, Makoto 著作を一覧する
Nagai, Akiko 著作を一覧する
Yamagata, Zentaro 著作を一覧する
Kiyohara, Yutaka 著作を一覧する
Muto, Kaori 著作を一覧する
Kamatani, Yoichiro 著作を一覧する
Ninomiya, Toshiharu 著作を一覧する
Matsuda, Koichi 著作を一覧する
Kubo, Michiaki 著作を一覧する
Nakamura, Yusuke 著作を一覧する
BioBank Japan Cooperative Hospital Group 著作を一覧する
Tamakoshi, Akiko 著作を一覧する
キーワード: Breast cancer
Histological type
Hormone receptor
発行日: 2017年 3月
出版者: Elsevier
誌名: Journal of epidemiology
巻: 27
号: 3, Supplement
開始ページ: S58
終了ページ: S64
出版社 DOI: 10.1016/
抄録: Background: Breast cancer is currently the most common type of cancer in Japanese females. Unlike most other types of cancer, breast cancer develops more frequently in middle-aged females than in elderly females. Methods: Of all Japanese female breast cancer patients aged ≥20 years whom the BioBank Japan Project originally enrolled between 2003 and 2008, 2034 were registered within 90 days after their diagnosis. We described the lifestyle and clinical characteristics of these patients at study entry. Furthermore, we examined the effect of these characteristics on all-cause mortality. Results: In the female patients registered within 90 days after diagnosis, the frequency of stage 0 or unclassified, stage I, II, III and IV were 11.4%, 47.9%, 37.0%, 2.9% and 0.8%, respectively. The proportion of histological types was 12.9% for non-invasive carcinoma (ductal carcinoma and lobular carcinoma), 81.0% for invasive carcinoma (papillotubular carcinoma, solid tubular carcinoma, scirrhous carcinoma and special types), 0.2% for Paget's diseases and 5.8% for others. Those positive for the estrogen and progesterone receptors accounted for 75.8% and 62.1% of all patients, respectively. Among 1860 female participants registered within 90 days, 218 participants died during 144,54 person-years of follow-up. More advanced stage, elevation of serum carcinoembryonic antigen and carbohydrate antigen 15-3 levels and absence of the estrogen receptor at study entry were crudely associated with an increased risk of all-cause mortality after adjustment for age. Conclusions: This study showed the association of several clinical characteristics with all-cause mortality in female breast cancer patients.
資料タイプ: article
出現コレクション:雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

提供者: 玉腰 暁子


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