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Characteristics and prognosis of Japanese female breast cancer patients : The BioBank Japan project

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Title: Characteristics and prognosis of Japanese female breast cancer patients : The BioBank Japan project
Authors: Nakamura, Koshi Browse this author →KAKEN DB
Okada, Emiko Browse this author →KAKEN DB
Ukawa, Shigekazu Browse this author →KAKEN DB
Hirata, Makoto Browse this author
Nagai, Akiko Browse this author
Yamagata, Zentaro Browse this author
Kiyohara, Yutaka Browse this author
Muto, Kaori Browse this author
Kamatani, Yoichiro Browse this author
Ninomiya, Toshiharu Browse this author
Matsuda, Koichi Browse this author →KAKEN DB
Kubo, Michiaki Browse this author →KAKEN DB
Nakamura, Yusuke Browse this author →KAKEN DB
BioBank Japan Cooperative Hospital Group Browse this author
Tamakoshi, Akiko Browse this author →KAKEN DB
Keywords: Breast cancer
Histological type
Hormone receptor
Issue Date: Mar-2017
Publisher: Elsevier
Journal Title: Journal of epidemiology
Volume: 27
Issue: 3, Supplement
Start Page: S58
End Page: S64
Publisher DOI: 10.1016/
Abstract: Background: Breast cancer is currently the most common type of cancer in Japanese females. Unlike most other types of cancer, breast cancer develops more frequently in middle-aged females than in elderly females. Methods: Of all Japanese female breast cancer patients aged ≥20 years whom the BioBank Japan Project originally enrolled between 2003 and 2008, 2034 were registered within 90 days after their diagnosis. We described the lifestyle and clinical characteristics of these patients at study entry. Furthermore, we examined the effect of these characteristics on all-cause mortality. Results: In the female patients registered within 90 days after diagnosis, the frequency of stage 0 or unclassified, stage I, II, III and IV were 11.4%, 47.9%, 37.0%, 2.9% and 0.8%, respectively. The proportion of histological types was 12.9% for non-invasive carcinoma (ductal carcinoma and lobular carcinoma), 81.0% for invasive carcinoma (papillotubular carcinoma, solid tubular carcinoma, scirrhous carcinoma and special types), 0.2% for Paget's diseases and 5.8% for others. Those positive for the estrogen and progesterone receptors accounted for 75.8% and 62.1% of all patients, respectively. Among 1860 female participants registered within 90 days, 218 participants died during 144,54 person-years of follow-up. More advanced stage, elevation of serum carcinoembryonic antigen and carbohydrate antigen 15-3 levels and absence of the estrogen receptor at study entry were crudely associated with an increased risk of all-cause mortality after adjustment for age. Conclusions: This study showed the association of several clinical characteristics with all-cause mortality in female breast cancer patients.
Type: article
Appears in Collections:医学院・医学研究院 (Graduate School of Medicine / Faculty of Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 玉腰 暁子

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