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Clinical and histopathological characteristics of patients with prostate cancer in the BioBank Japan project

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Title: Clinical and histopathological characteristics of patients with prostate cancer in the BioBank Japan project
Authors: Ukawa, Shigekazu Browse this author →KAKEN DB
Nakamura, Koshi Browse this author →KAKEN DB
Okada, Emiko Browse this author →KAKEN DB
Hirata, Makoto Browse this author
Nagai, Akiko Browse this author
Yamagata, Zentaro Browse this author
Muto, Kaori Browse this author
Matsuda, Koichi Browse this author →KAKEN DB
Ninomiya, Toshiharu Browse this author
Kiyohara, Yutaka Browse this author
Kamatani, Yoichiro Browse this author
Kubo, Michiaki Browse this author →KAKEN DB
Nakamura, Yusuke Browse this author →KAKEN DB
BioBank Japan Cooperative Hospital Group Browse this author
Tamakoshi, Akiko Browse this author →KAKEN DB
Keywords: BioBank Japan project
Lifestyle
Prostate cancer
Survival
Tumor biomarker
Issue Date: Mar-2017
Publisher: Elsevier
Journal Title: Journal of epidemiology
Volume: 27
Issue: 3, Supplement
Start Page: S65
End Page: S70
Publisher DOI: 10.1016/j.je.2016.12.008
Abstract: Background: Prostate cancer is the sixth leading cause of cancer-related deaths in Japan. We aimed to elucidate the clinical and histopathological characteristics of patients with prostate cancer in the BioBank Japan (BBJ) project. Methods: Four thousand, seven hundred and ninety-three patients diagnosed with prostate cancer in the BBJ project were included. Clinical and histopathological data, including causes of death, were analyzed. Relative survival (RS) rates of prostate cancer were calculated. Results: Four thousand, one hundred and seventy-one prostate cancer patients with available histological data had adenocarcinoma. The mean age of the patients was 72.5 years. The proportion of patients who were non-smokers, non-drinkers, had a normal body mass index, did not exercise, had a normal prostate-specific antigen level, and had a family history of prostate cancer were 30.7%, 28.0%, 66.6%, 58.1%, 67.6%, and 6.5%, respectively. The proportion of patients with Stage II, III, and IV disease were 24.4%, 7.3%, and 4.4%, respectively. After limiting to patients with a time from the initial diagnosis of prostate cancer to entry into the study cohort of ≤90 days (n = 869), the 5- and 10-year RS rates were 96.3% and 100.5%, respectively, although we were unable to consider management strategies due to a plenty of data missing. Conclusions: We provide an overview of patients with prostate cancer in the BBJ project. Our findings, coupled with those from various high throughput “omics” technologies, will contribute to the implementation of prevention interventions and medical management of prostate cancer patients.
Rights: http://creativecommons.org/licenses/by-nc-nd/4.0/
Type: article
URI: http://hdl.handle.net/2115/65816
Appears in Collections:医学院・医学研究院 (Graduate School of Medicine / Faculty of Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 玉腰 暁子

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