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Occult fetomaternal hemorrhage in women with pathological placenta with respect to permeability

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Title: Occult fetomaternal hemorrhage in women with pathological placenta with respect to permeability
Other Titles: Occult FMH
Authors: Umazume, Takeshi Browse this author →KAKEN DB
Yamada, Takahiro Browse this author →KAKEN DB
Morikawa, Mamoru Browse this author →KAKEN DB
Ishikawa, Satoshi Browse this author
Kojima, Takashi Browse this author
Cho, Kazutoshi Browse this author →KAKEN DB
Masauzi, Nobuo Browse this author
Minakami, Hisanori Browse this author →KAKEN DB
Keywords: alpha-fetoprotein
fetomaternal hemorrhage
placenta previa
placental mesenchymal dysplasia
Issue Date: Jun-2016
Publisher: Wiley-Blackwell
Journal Title: Journal of Obstetrics and Gynaecology Research
Volume: 42
Issue: 6
Start Page: 632
End Page: 639
Publisher DOI: 10.1111/jog.12959
PMID: 26935605
Abstract: Aim: Women with pre-eclampsia (PE), placenta previa (PP), placental abruption (PA), and placental mesenchymal dysplasia (PMD) have been described as having placental permeability dysfunction. This study was performed to determine whether occult fetomaternal hemorrhage (FMH) is common in women with such complications and in women with non-reassuring fetal status. Methods: Forty-one antenatal and 39 postnatal blood samples were obtained from 46 women, including 11 with placental permeability dysfunction (5, 3, 2, and 1 with PE, PP, PA, and PMD, respectively) and 35 controls without such complications. To estimate the amount of fetal red blood cells, flow cytometry was performed using the fetal cell count system with two antibodies against fetal hemoglobin and carbonic anhydrase and the β-γ system with two monoclonal antibodies against hemoglobin β-chain and hemoglobin γ-chain. A diagnosis of FMH was made when the fraction size of the isolated cell population on scatter plots expressing fetal hemoglobin alone or hemoglobin γ-chain alone accounted for ≥ 0.02% of the total cell population on scatter plots. Results: FMH was identified in five women, including one each with PE, PA, PP, PMD, and no complications. Thus, the prevalence rate of FMH was significantly higher in women with complications than in controls (36% [4/11] vs 2.9% [1/35], respectively, P = 0.009). The FMH occurrence rate did not differ between women with and without non-reassuring fetal status (7.7% [1/13] vs 12% [4/33], respectively, P = 1.000). Conclusion :The risk of fetal red blood cells trafficking into the maternal circulation may be increased in women complicated with PE, PA, PP, and PMD.
Rights: This is the peer reviewed version of the following article: Umazume, T., Yamada, T., Morikawa, M., Ishikawa, S., Kojima, T., Cho, K., Masauzi, N., and Minakami, H. (2016) Occult fetomaternal hemorrhage in women with pathological placenta with respect to permeability. J. Obstet. Gynaecol. Res., 42: 632–639, which has been published in final form at This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving.
Type: article (author version)
Appears in Collections:北海道大学病院 (Hokkaido University Hospital) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 山田 崇弘

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