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Occult fetomaternal hemorrhage in women with pathological placenta with respect to permeability

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タイトル: Occult fetomaternal hemorrhage in women with pathological placenta with respect to permeability
その他のタイトル: Occult FMH
著者: Umazume, Takeshi 著作を一覧する
Yamada, Takahiro 著作を一覧する
Morikawa, Mamoru 著作を一覧する
Ishikawa, Satoshi 著作を一覧する
Kojima, Takashi 著作を一覧する
Cho, Kazutoshi 著作を一覧する
Masauzi, Nobuo 著作を一覧する
Minakami, Hisanori 著作を一覧する
キーワード: alpha-fetoprotein
fetomaternal hemorrhage
placenta previa
placental mesenchymal dysplasia
pre-eclampsia
発行日: 2016年 6月
出版者: Wiley-Blackwell
誌名: Journal of Obstetrics and Gynaecology Research
巻: 42
号: 6
開始ページ: 632
終了ページ: 639
出版社 DOI: 10.1111/jog.12959
抄録: Aim: Women with pre-eclampsia (PE), placenta previa (PP), placental abruption (PA), and placental mesenchymal dysplasia (PMD) have been described as having placental permeability dysfunction. This study was performed to determine whether occult fetomaternal hemorrhage (FMH) is common in women with such complications and in women with non-reassuring fetal status. Methods: Forty-one antenatal and 39 postnatal blood samples were obtained from 46 women, including 11 with placental permeability dysfunction (5, 3, 2, and 1 with PE, PP, PA, and PMD, respectively) and 35 controls without such complications. To estimate the amount of fetal red blood cells, flow cytometry was performed using the fetal cell count system with two antibodies against fetal hemoglobin and carbonic anhydrase and the β-γ system with two monoclonal antibodies against hemoglobin β-chain and hemoglobin γ-chain. A diagnosis of FMH was made when the fraction size of the isolated cell population on scatter plots expressing fetal hemoglobin alone or hemoglobin γ-chain alone accounted for ≥ 0.02% of the total cell population on scatter plots. Results: FMH was identified in five women, including one each with PE, PA, PP, PMD, and no complications. Thus, the prevalence rate of FMH was significantly higher in women with complications than in controls (36% [4/11] vs 2.9% [1/35], respectively, P = 0.009). The FMH occurrence rate did not differ between women with and without non-reassuring fetal status (7.7% [1/13] vs 12% [4/33], respectively, P = 1.000). Conclusion :The risk of fetal red blood cells trafficking into the maternal circulation may be increased in women complicated with PE, PA, PP, and PMD.
Rights: This is the peer reviewed version of the following article: Umazume, T., Yamada, T., Morikawa, M., Ishikawa, S., Kojima, T., Cho, K., Masauzi, N., and Minakami, H. (2016) Occult fetomaternal hemorrhage in women with pathological placenta with respect to permeability. J. Obstet. Gynaecol. Res., 42: 632–639, which has been published in final form at http://dx.doi.org/10.1111/jog.12959. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving.
資料タイプ: article (author version)
URI: http://hdl.handle.net/2115/65828
出現コレクション:雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

提供者: 山田 崇弘

 

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