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Effects of infant flow Bi-NCPAP on apnea of prematurity

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Title: Effects of infant flow Bi-NCPAP on apnea of prematurity
Authors: Ishihara, Chie Browse this author
Ibara, Satoshi Browse this author
Ohsone, Yoshiteru Browse this author
Kato, Eiji Browse this author
Tokuhisa, Takuya Browse this author
Yamamoto, Yutaka Browse this author
Maede, Yoshinobu Browse this author
Kuwahara, Takako Browse this author
Minakami, Hisanori Browse this author →KAKEN DB
Keywords: apnea
bronchopulmonary dysplasia
low birthweight
tracheal intubation
Issue Date: Jun-2016
Publisher: Wiley-Blackwell
Journal Title: Pediatrics international
Volume: 58
Issue: 6
Start Page: 456
End Page: 460
Publisher DOI: 10.1111/ped.12854
PMID: 26620042
Abstract: Background: Infant flow biphasic nasal continuous positive airway pressure (Bi-NCPAP) and regular NCPAP (Re-NCPAP) are equally useful with respect to the rate of successful weaning from mechanical ventilation. It remains unclear, however, whether Bi-NCPAP or Re-NCPAP is more effective for reducing apnea of prematurity (AOP). Methods: A multicenter randomized controlled study was conducted of 66 infants assigned to receive Bi-NCPAP and 66 assigned to receive Re-NCPAP for respiratory support after extubation. Primary outcome was the number of AOP events during the 48 h observation period after successful extubation, defined as no reintubation and no adverse events associated with the use of NCPAP during the observation period. The secondary outcome was successful extubation. Reintubation was at the discretion of the attending physician. Results: Baseline characteristics were similar between the two groups. The number of AOP events during the 48 h observation period was significantly lower in infants with Bi-NCPAP than in those with Re-NCPAP (5.2 ± 6.5 vs 10.3 ± 10.9 per infant, respectively; P = 0.002). The rate of successful extubation tended to be greater in those with Bi-NCPAP than in those with Re-NCPAP (92.4%, 61/66 vs 80.3%, 53/66, respectively; P = 0.074). Adverse events occurred in only one of 132 infants: erosive dermatitis developed on the nose after application of Re-NCPAP. The risk of reintubation did not differ significantly between the two groups (7.6%, 5/66 for Bi-NCPAP vs 18.2%, 12/66 for Re-NCPAP; P = 0.117). Conclusions: Bi-NCPAP was superior to Re-NCPAP for reduction of AOP following extubation.
Rights: This is the peer reviewed version of the following article: Ishihara, C., Ibara, S., Ohsone, Y., Kato, E., Tokuhisa, T., Yamamoto, Y., Maede, Y., Kuwahara, T., and Minakami, H. (2016) Effects of infant flow Bi-NCPAP on apnea of prematurity. Pediatrics International, 58: 456–460, which has been published in final form at This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving.
Type: article (author version)
Appears in Collections:医学院・医学研究院 (Graduate School of Medicine / Faculty of Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 水上 尚典

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