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PSD-95 regulates synaptic kainate receptors at mouse hippocampal mossy fiber-CA3 synapses

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Title: PSD-95 regulates synaptic kainate receptors at mouse hippocampal mossy fiber-CA3 synapses
Authors: Suzuki, Etsuko Browse this author
Kamiya, Haruyuki Browse this author →KAKEN DB
Keywords: Kainate receptor
Postsynaptic density
Issue Date: Jun-2016
Publisher: Elsevier
Journal Title: Neuroscience research
Volume: 107
Start Page: 14
End Page: 19
Publisher DOI: 10.1016/j.neures.2015.12.011
PMID: 26746114
Abstract: Kainate-type glutamate receptors (KARs) are the third class of ionotropic glutamate receptors whose activation leads to the unique roles in regulating synaptic transmission and circuit functions. In contrast to AMPA receptors (AMPARs), little is known about the mechanism of synaptic localization of KARs. PSD-95, a major scaffold protein of the postsynaptic density, is a candidate molecule that regulates the synaptic KARs. Although PSD-95 was shown to bind directly to KARs subunits, it has not been tested whether PSD-95 regulates synaptic KARs in intact synapses. Using PSD-95 knockout mice, we directly investigated the role of PSD-95 in the KARs-mediated components of synaptic transmission at hippocampal mossy fiber-CA3 synapse, one of the synapses with the highest density of KARs. Mossy fiber EPSCs consist of AMPA receptor (AMPAR)-mediated fast component and KAR-mediated slower component, and the ratio was significantly reduced in PSD-95 knockout mice. The size of KARs-mediated field EPSP reduced in comparison with the size of the fiber volley. Analysis of KARs-mediated miniature EPSCs also suggested reduced synaptic KARs. All the evidence supports critical roles of PSD-95 in regulating synaptic KARs.
Rights: © 2016. This manuscript version is made available under the CC-BY-NC-ND 4.0 license
Type: article (author version)
Appears in Collections:医学院・医学研究院 (Graduate School of Medicine / Faculty of Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 神谷 温之

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